{"id":16614,"date":"2021-09-27T10:05:51","date_gmt":"2021-09-27T10:05:51","guid":{"rendered":"https:\/\/igcz.poznan.pl\/?page_id=16614\/"},"modified":"2023-01-04T12:43:27","modified_gmt":"2023-01-04T12:43:27","slug":"independent-research-group-of-rna-biology","status":"publish","type":"page","link":"https:\/\/igcz.poznan.pl\/en\/structure\/independent-research-groups\/independent-research-group-of-rna-biology\/","title":{"rendered":"Independent Research Group of RNA Biology"},"content":{"rendered":"\n\n\n
Group leader<\/span>
\n\"\"<\/a>JADWIGA JARUZELSKA
\nProf. of biology
\njadwiga.jaruzelska@igcz.poznan.pl
\nphone: +48 616 579 208
\nCV<\/a><\/td>\n		\"\"<\/a>
\nThe model of RNA-Binding Proteins (RBPs) mediated posttranscriptional gene expression regulation exemplified by a PUM protein
\n<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

Group members<\/strong><\/a><\/span><\/h4>\n<\/td>\n

\n

Research<\/a><\/strong><\/span><\/h4>\n<\/td>\n

\n

Publications<\/strong><\/a><\/span><\/h4>\n<\/td>\n

\n

Projects<\/strong><\/a><\/span><\/h4>\n<\/td>\n

\n

Awards<\/strong><\/a><\/span><\/h4>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n
<\/a>Assistant professors<\/strong><\/td>\nPhD students<\/strong><\/td>\nPostdoctoral fellows<\/strong><\/td>\nTechnical associates<\/strong><\/td>\n<\/tr>\n
\n

\"\"<\/a>KAMILA KUSZ-ZAMELCZYK<\/p>\n

Associate prof. of medical sciences
\nkamila.kusz-zamelczyk@igcz.poznan.pl
\n+48 616 579 220<\/p>\n<\/td>\n

\n

\"\"<\/a>ERKUT ILASLAN<\/p>\n

Graduate student
\nerkut.ilaslan@igcz.poznan.pl
\n+48 616 579 206<\/p>\n<\/td>\n

\n

\"\"<\/a>MARCIN PIOTR SAJEK<\/p>\n

PhD in medical sciences
\nmarcin.sajek@igcz.poznan.pl
\n+48 616 579 206<\/p>\n<\/td>\n

\n

\"\"<\/a>KRYSTYNA KWIATKOWSKA<\/p>\n

MS. in medical biotech.
\nkrystyna.kwiatkowska@igcz.poznan.pl
\n+48 616 579 206<\/p>\n<\/td>\n<\/tr>\n

<\/td>\n\n

\"\"<\/a>MATISA ALLA<\/p>\n

Graduate student
\nmatisa.alla@igcz.poznan.pl
\n+48 616 579 207<\/p>\n<\/td>\n

\n

\"\"<\/a>MACIEJ JERZY \u015aMIA\u0141EK<\/p>\n

PhD in medical sciences
\nmaciej.smialek@igcz.poznan.pl
\n+48 616 579 206<\/p>\n<\/td>\n

\n

\"\"<\/a>\u017bANETA LEMA\u0143SKA<\/p>\n

MS. in medical biotech.
\nzaneta.lemanska@igcz.poznan.pl
\n+48 616 579 206<\/p>\n<\/td>\n<\/tr>\n

<\/td>\n\n

\n<\/td>\n

\n

\"\"<\/a>LAKSHMI BELLARY<\/span><\/p>\n

PhD in animal sciences<\/span>
\nlakshmi.bellary@igcz.poznan.pl<\/span>
\n+48 616 579 206<\/p>\n<\/td>\n

\n

\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/a>Research<\/h2>\n
\"Pierwotne<\/a>
Differentiating human primordial germ-like cells \u2013 PGLCs from human stem cell-line W15<\/figcaption><\/figure>\n

Regulation of gene expression in early stages of human germ cell development, in the context of infertility<\/strong><\/p>\n

This project is focused on the posttranscriptional regulatory mechanisms of the initial stages of the human germ cell development, involving RNA-binding proteins, such as PUMILIO and their cofactors such as NANOS. These proteins bind 3\u2019 untranslated regions of specific target mRNAs and in cooperation with the miRNA machinery determine their fate. We are identifying ribonucleoprotein (RNP) interactoms built by such proteins and study their dynamics during PGLCs specification and differentiation. In particular, mutated RNA-binding proteins from patients suffering infertility are used to identify potential changes in such interactomes. We expect that such approach will help to pinpoint crucial pathways in germ cell specification and early development and unveil molecular basis of human infertility. As the model, we use the human W15 stem cell-line and differentiate it towards PGLCs. We perform several high throughput approaches analyzes and use bioinformatic tools.<\/p>\n

Keywords<\/strong>:\u00a0posttranscriptional gene expression regulation, RNA-binding proteins, microRNAs, germ cells<\/p>\n

Identification of novel genes implicated in human sex determination<\/strong><\/p>\n

This study is focused on sheding light on molecular mechanisms of sex determination and differentiation on order to understand genetic bases of sex development disorders (DSD). We identified a couple of candidate genes involved in sex determination and differentiation and validate their connection with those processes. We coordinate the work of Polish groups within an international project addressing this issue. The project is conducted by the University of Geneva, in cooperation with the Institute of Human Genetics of the Polish Academy of Sciences in Pozna\u0144, Medical State University of Yerevan, National Academy of Sciences of Ukraine in Kyiv, Pozna\u0144 University of Medical Sciences, and the Children\u2019s Memorial Health Institute in Warsaw.<\/p>\n

Keywords<\/b>:\u00a0human sex determination, disorders of sex development (DSD)<\/p>\n

<\/a>Projects<\/h2>\n
    \n
  • National Science Center Poland 2019\/35\/B\/NZ1\/01665 (2020-2024); NANOS1 RNP-interactome: structure and dynamics during specification\/early stages of human germ cell development \u2013 significance for human reproduction (principal investigator)<\/li>\n
  • National Science Center Poland OPUS 2013\/09\/B\/NZ1\/01878<\/em> (2013-2017); Global PUMILIO regulation of mRNAs and role of MAELSTROM, a nuage component and a cancer testis marker, in human seminoma (principal investigator)<\/li>\n
  • Swiss National Science Foundation SCOPES number IZ73ZO_152347\/1<\/em> (2013-2016); Genetics of human disorders of sexual development (Polish coordinator)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

    Group leader JADWIGA JARUZELSKA Prof. of biology jadwiga.jaruzelska@igcz.poznan.pl phone: +48 616 579 208 CV The model of RNA-Binding Proteins (RBPs) mediated posttranscriptional gene expression regulation exemplified by a PUM protein Group members Research Publications Projects Awards Assistant professors PhD students Postdoctoral fellows Technical associates KAMILA KUSZ-ZAMELCZYK Associate prof. of medical sciences kamila.kusz-zamelczyk@igcz.poznan.pl +48 616 579 […]<\/p>\n","protected":false},"author":103,"featured_media":0,"parent":11141,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/page-fullwidth.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-16614","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nIndependent Research Group of RNA Biology - Institute of Human Genetics Polish Academy of Sciences<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/igcz.poznan.pl\/en\/structure\/independent-research-groups\/independent-research-group-of-rna-biology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Independent Research Group of RNA Biology - 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