The latest research findings and information from the World Health Organization (WHO) classify infertility as a social disease affecting 10–18% of couples. It is estimated that the so-called male factor currently accounts for 30–40% of all infertility cases. The Department’s research activities are based on a comprehensive experimental approach to men experiencing reproductive failure, taking their karyotypes into account. The studies include the characterization of the genetic content of germ cells, as well as the epigenetic and biochemical quality of sperm, which are essential for the course of spermatogenesis. The simultaneous assessment of all these parameters and their interrelationships may contribute to the development of new tests evaluating both the structural and regulatory layers of sperm genetic material.
Department of Reproductive Biology and Genomics of Gamete
Featured publications
Impact of sperm fractionation on chromosome positioning, chromatin integrity, DNA methylation, and hydroxymethylation level
Graczyk Z, Kostyk J, Pospieszna J, Myślicka Z, Kamieniczna M, Frączek M, Olszewska M, Kurpisz M.
Cell Mol Biol Lett, 2025 Dec 23;30 (1): 146 (37 stron). doi: 10.1186/s11658-025-00830-7IF-10.2 MNiSW-100
All publications
Featured research projects
1. NSC Research Project No. 2020/38/E/NZ2/00134 (2021-2027)
2. NSC Research Project No. 2015/17/D/NZ5/03442
3. MSHE Research Project No. NdS-II/SP/0288/2024/01
4. NSC Research Project No. 2024/53/B/NZ5/02183
Collaborations
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
Department of Medical Genetics, Medical University of Warsaw, Warsaw, Poland
Poznań University of Life Sciences, Poznań, Poland
Poznan University of Medical Sciences, Poznań, Poland
University Clinical Centre, Medical University of Gdańsk, Gdańsk, Poland
Gynecological Obstetric Clinical Hospital of Poznan University of Medical Sciences, Poznań, Poland
University of Kent, Canterbury, United Kingdom
University of Pittsburgh, Pittsburgh, PA, USA
State Institution “Amosov National Scientific Center of Cardiovascular Surgery and Hereditary Pathology of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
Awards
Travel grant International Society of Andrology (ISA). 13th European Congress of Andrology (ECA) 2024. Sztokholm, 3-8.09.2024 r.
Travel grant International Society of Andrology (ISA)
The 2022 International Travel Award
for oral presentation: 'Causative Influence of Tcte1 Knockout on energetic chain transportation, apoptosis and spermatogenesis - implications for male infertility'
Early Stage Investigator registration scholarship, American Society of Andrology, 46th Annual Conference
Early Stage Investigator registration scholarship
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future.
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: : “Analysis of DNA methylation pattern in spermatozoa of infertile men with oligozoospermia”. The material regarding the nominee is available on website: https://rzeczo.pl/blog/2020/07/08/nieplodnosc-to-tez-epigenetyka/.