Our scientific interests concentrate on cancer genetics and the genetics of the senses. We use various techniques in our routine practice, from molecular biology and cytogenetics (microarrays, NGS, pyrosequencing, FISH and FICTION) supplemented by functional analyses. The aim of the research is the identification of genomic and epigenomic alterations that contribute to the development of neoplasms and diseases of the sensory organs. To that end, we work closely with renowned Polish and foreign scientific groups.
Department of Cancer Genetics
Featured publications
Challenges in the diagnosis and treatment of the malignant adnexal neoplasms of the head and neck.
Wierzbicka M, Kraiński P, Bartochowska A
Curr Opin Otolaryngol Head Neck Surg, 2023 Apr 1; 31 (2):134-145, Epub 2023 Jan 24, doi: 10.1097/MOO.0000000000000872IF-1.819 MNiSW-70
Prenatal Detection of a FOXF1 Deletion in a Fetus with ACDMPV and Hydronephrosis.
Bzdęga K, Kutkowska-Kaźmierczak A, Deutsch Gail H, Plaskota I, Smyk M, Niemiec M, Barczyk A, Obersztyn E, Modzelewski J, Lipska I, Stankiewicz P, Gajęcka M, Rydzanicz M, Płoski R, Szczapa T, Karolak JA
Genes (MDPI), 2023, 14 (3), 563 8 str., 563. https://doi.org/10.3390/genes14030563IF-4.142 MNiSW-100
The impaired wound healing proces is a major factor in remodeling of the corneal epithelium in adult and adolscent patients with Keratoconus.
Jaśkiewicz K, Maleszka-Kurpiel M, Matuszewska E, Kabza M, Rydzanicz M, Malinowski R, Płoski R, Matysiak J, Gajęcka M
Inv Opht Vis Sci, 2023, 64 (2): 1-19.IF-4.925 MNiSW-140
Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
López C, Schleussner N, Bernhart SH, Kleinheinz K, Sungalee S, Sczakiel HL, Toprak UH, Wagener R, Bens S, Giefing M, González Sánchez JC, Jan M, Kreuz M, Mottok A, Müller JN, Seufert J, Hoffmann S, Korbel JO, Russell RB, Schüle R, Trümper L, Klapper W, ICGC MMML-Seq Consortium, Schlesner M, Mathas S, Siebert R
Haemotologica, 2023 Feb, 109 (2):543-554, Epub 2022 Apr 28, doi./10.3324/haematol.2021.280005IF-11.04 MNiSW-140
Clinical outcomes of therapy-related acute myeloid leukemia: over 20 years long single center retrospective analysis.
Adamska M, Kowal-Wiśniewska E, Przybyłowicz-Chalecka A, Barańska M, Łojko-Dankowska A, Joks M, Kanduła Z, Jarmuż-Szymczak M, Gil L
Pol Arch Inter Med, 2023, 133 (1): 16344, 11 str., Epub 2022 Sept., doi: 10.20452/pamw.16344IF-5.218 MNiSW-140
Differential methylation of microRNA encoding genes may contribute to high myopia.
Swierkowska J, Vishweswaraiah S, Mrugacz M, Radhakrishna U, Gajecka M
Frontiers in Genetics, 2023: 9 str., doi: 10.2174/1573407218666220524114244IF-4.772 MNiSW-100
Intraoperative margins in oral and oropharyngeal cancer transoral surgery – benefit from sampling method modifications.
Klimza H, Greczka G, Grabowski L, Majewski P, Banaszewski J, Wierzbicka M
Otolaryngolo Pol, 2022, 76 (6): 1-8MNiSW-100
Anterolateral thigh free flap reconstruction of pharyngoesophageal defect caused by radiotherapy for laryngeal cancere: A case report.
Kmiecik M, Nogal P, Wierzbicka M, Jackowska J
Oral Oncol, epub 2022 Sep 24, 134, art. 106135IF-5,972 MNiSW-140
Pupillometry as a Measure of Listening Effort in Patient with Bone-nchored Hearing Systems.
Gawęcki W, Krzystanek K, Węgrzyniak M, Gibasiewicz R, Wierzbicka M
J Clin Med, 2022, 11, 14: 4218.IF-4,924 MNiSW-140
Robot-Assisted Electrode Insertion in Cochlear Implantation Controlled by Intraoperative Electrocochleography - A Pilot Study.
Gawęcki W, Balcerowiak A, Podlawska P; Borowska P. Gibasiewicz R, Szyfter W, Wierzbicka M
J Clin Med (MDPI), 2022, 11 (23), 7045, 13 str, https://doi.org/10.3390/jcm11237045IF-4,964 MNiSW-140
All publications
Featured research projects
1. Project OPUS
„Genome-wide mutation screen of the regulome in laryngeal squamous cell carcinoma.”
Duration: 2017-2020
2. Project PRELUDIUM
„Role of miR-299-5p in pathogenesis of laryngeal squamous cell carcinoma.”
Duration: 2017-2020
3. Project OPUS
“The expression analysis of genes and proteins potentially involved in lymph node metastasis formation in laryngeal cancer”
Duration: 2016-2019
4. Project HARMONIA
“Identification of miRNAs involved in classical Hodgkin lymphoma pathogenesis using combined expression and mutation profiling and functional analyses.”
Duration: 2015-2018
5. Project HARMONIA
“Whole exome sequencing in Polish patients with sporadic keratoconus and a pilot study of keratoconus proteomic and metabolomic profiles of tears.”
Duration: 2014-2017
Collaborations
Department of Otolaryngology, Poznan University of Medical Sciences, Poznań, Poland.
Institute of Human Genetics, Christian Albrecht University, Kiel, Germany.
Institute of Cell Biology (Tumour Research), University Duisburg-Essen, Germany.
Senckenberg Institute of Pathology, Goethe University Frankfurt, Germany.
Department of Otorhinolaryngology – Head and Neck Surgery, University of Turku, Finland.
Department of Molecular and Human Genetics, Baylor College of Medicine Houston, TX, USA.
Awards
Awarded:
mgr inż. Ewelina Kowal-Wiśniewska
Nagroda im. prof. Aleksandra Szczygła za pracę naukowo-badawczą opublikowaną w roku 2021
Given by: Polskie Towarzystwo Nauk Żywieniowych
za pracę naukowo-badawczą opublikowaną w roku 2021 z zakresu nauki o żywieniu człowieka: Alteration of the Early Development Environment by Maternal Diet and the Occurrence of Autistic-like Phenotypes in Rat Offspring.
Awarded:
dr n. med. Julia Paczkowska
IX Edition of the Competition of the Polish Academy of Sciences in Poznan for the best scientific publication, which was published in 2020 and the lead author was a PhD student.
Given by: Polish Academy of Sciences in Poznan
Dr Julia Paczkowska – lauerate of the IX Edition of the Competition of the Polish Academy of Sciences in Poznan for the best scientific publication, which was published in 2020 and the lead author was a PhD student.
Awarded:
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr n. med. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr n. med. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
Award of the Division of Medical Sciences of the Polish Academy of Sciences
Given by: Division of Medical Sciences of the Polish Academy of Sciences
for 5 publications concerning loss of tumor suppressor genes in squamous cell carcinoma
Awarded:
dr n. med. i n. o zdr. Joanna Świerkowska
EMBO Short-term fellowship
Given by: EMBO
Joanna Świerkowska from the Department of Cancer Genetics received an EMBO short-term fellowship for the implementation of the project “The role of the noncoding miRNA and enhancers in high myopia” at Erasmus Medical Center, Rotterdam, The Netherlands
Awarded:
dr n. med. Magdalena Kostrzewska-Poczekaj
EMBO short-term fellowship
Given by: EMBO
Magdalena Kostrzewska-Poczekaj from the Department of Cancer Genetics received an EMBO short-term fellowship for the implementation of the project "Platelets and platelet microparticles (PMP) as omnipresent RNA messengers in inflammatory diseases" at University Hospital Schleswig Holstein, Clinic for Otorhinolaryngology - Head and Neck Surgery, Luebeck in Germany.
Awarded:
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Powołanie na członka Rady Naukowej Instytutu Genetyki Człowieka PAN w Poznaniu na kadencję 2019-2022.
Given by: Rada Naukowa Instytutu Genetyki Człowieka PAN
Awarded:
prof. dr hab. n. med. Marzena Gajęcka
Kosciuszko Foundation Fellowship
Given by: Kosciuszko Foundation
Prof. Marzena Gajecka has been awarded a Kosciuszko Foundation Fellowship for the academic year 2019/2020, to visit Baylor College of Medicine and Texas Children’s Hospital in Houston, TX, US. The Kosciuszko Foundation promotes closer ties between Poland and the United States through educational, scientific and cultural exchanges. The Kosciuszko Foundation annually awards a number of Fellowships/Grants to Poles for advanced study, research, and/or teaching at universities and other institutions of higher learning in the United States.
Awarded:
mgr Adam Ustaszewski
Msc Adam Ustaszewski otrzymał stypendium międzynarodowe (Short-Term Fellowship) przyznane przez Europejską Organizację Biologii Molekularnej (EMBO)
Given by: European Molecular Biology Organization (EMBO).
Mgr Adam Ustaszewski otrzymał stypendium międzynarodowe (Short-Term Fellowship) przyznane przez Europejską Organizację Biologii Molekularnej (EMBO) na projekt badawczy zatytułowany „Identification of putative alternations of open chromatin regions in Classical Hodgkin Lymphoma by integration of ATAC-Seq and high-throughput sequencing of cis-regulatory elements.”, przyznane przez Europejską Organizację Biologii Molekularnej (EMBO). Poznań. 24.01.2019 r.
Awarded:
mgr inż. Ewelina Kowal-Wiśniewska
Master’s thesis Award
Given by: Poznań University of Life Sciences
MSc. eng. Ewelina Kowal from the Departament of Cancer Genetics was awarded the Professor Jerzy Zwoliński first degree prize in the competition for the best master’s thesis written in the academic year 2017/2018 at the Poznan University of Life Sciences. Supervisor: Małgorzata Jarmuż-Szymczak, PhD Associate Professor.
Awarded:
mgr Adam Ustaszewski
Given by: Organizing committee 18th International Congress of Young Medical Scientists.
The oral presentation entitled 'Germline mutations in ALDH3A1 and RMDN2 genes as potential factors in salivary gland tumor development' received a distinction during 18th International Congress of Young Medical Scientists, Poznan, 14-16.06.2018 r.