Our scientific interests concentrate on cancer genetics and the genetics of the senses. We use various techniques in our routine practice, from molecular biology and cytogenetics (microarrays, NGS, pyrosequencing, FISH and FICTION) supplemented by functional analyses. The aim of the research is the identification of genomic and epigenomic alterations that contribute to the development of neoplasms and diseases of the sensory organs. To that end, we work closely with renowned Polish and foreign scientific groups.
Department of Cancer Genetics
Featured publications
MicroRNA signature in classical Hodgkin lymphoma.
Paczkowska J, Giefing M
IF-2,027 MNiSW-100
Słuch absolutny – poszukiwanie podłoża genetycznego.
Szyfter K, Witt M, Wierzbicka M
Post Chir. Głowy Szyi, 2/ 2020, 9-14MNiSW-20
Characterization of ocular surface microbial profiles revealed discrepancies between conjunctival and corneal microbiota.
Matysiak A, Kabza M, Karolak JA, Jaworska MM, Rydzanicz M, Płoski R, Szaflik JP, Gajęcka M
Pathogens, 2021, 10 (4): .e405, 11 str., https://doi.org/10.3390/pathogens10040405IF-3,018 MNiSW-100
Naczyniakowłókniak młodzieńczy – 20–letnie doświadczenia w leczeniu endoskopowym (publikacja dwujęzyczna). Juvenile nasopharyngeal angiofibroma—20 years of experience in endoscopic treatment.
Szyfter W, Balcerowiak A, Gawęcki W, Juszkat R, Wierzbicka M
MNiSW-40
An Incidental Finding of a Double-Lumen Trachea.
Piersiala K, Loroch A, Jackowska J, Wierzbicka M
Acta Med Portug, 2021 Mar, 34 (3), 2290231, https://doi.org/10.20344/amp.12000IF-0,628 MNiSW-20
Variants in FLRT3 and SLC35E2B identified using exome sequencing in seven high myopia families from Central Europe.
Świerkowska J, Karolak J, Gambin T., Rydzanicz M., Frajdenberg A, Mrugacz M., Podfigurna-Musielak M, Stankiewicz P., Lupski JR, Gajęcka M
Adv Med Sci, 2021 March, 66 (1) 192-8, doi: 10.1016/j.advms.2021.02.005IF-2,570 MNiSW-100
Proteomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma.
Huang C, Chen L, Savage SR, Eguez RV, Dou Y, Li Y, da Veiga Leprevost F, Jaehnig EJ, Lei JT, Wen B, Schnaubelt M, Krug K, Song X, Cieślik M, Chang HY, Wyczalkowski MA, Li K, Colaprico A, Li QK, Clark DJ, Hu Y, Cao L, Pan J, Wang Y, Cho KC, Shi Z, Liao Y, Jiang W, Anurag M, Ji J, Yoo S, Zhou DC, Liang WW, Wendl M, Vats P, Carr SA, Mani DR, Zhang Z, Qian J, Chen XS, Pico AR, Wang P, Chinnaiyan AM, Ketchum KA, Kinsinger CR, Robles AI, An E, Hiltke T, Mesri M, Thiagarajan M, Weaver AM, Sikora AG, Lubiński J, Wierzbicka M, Wiznerowicz M, Satpathy S, Gillette MA, Miles G, Ellis MJ, Omenn GS, Rodriguez H, Boja ES, Dhanasekaran SM, Ding L, Nesvizhskii AI, El-Naggar AK, Chan DW, Zhang H, Zhang B; Clinical Proteomic Tumor Analysis Consortium
Cancer Cell, 2021 Mar 8, 39 (3): 361-379, 36 str, Epub Jan 7, doi: 10.1016/j.ccell.2020.12.007IF-26,602 MNiSW-200
Niedosłuch przewodzeniowy po operacyjnym leczeniu otosklerozy – wieloletnie obserwacje.
Szyfter W, Gawęcki W, Bartochowska A, Balcerowiak A, Pietraszek M, Wierzbicka M
Wersja anglojęzyczna (tylko elektroniczna): Conductive hearing loss after surgical treatment of otosclerosis – long-term observations.
Otolaryngol Pol, 2021,75 (1): 1-6; DOI: 10.5604/01.3001.0014.6216, Epub 2020 Dec 29MNiSW-40
Antibiotic Resistance, Biofilm Formation, and Presence of Genes Encoding Virulence Factors in Strains Isolated from the Pharmaceutical Production Environment.
Ratajczak M, Kamińska D, Długaszewska J and Gajęcka M
IF-3,018 MNiSW-100
SERPINB2 – its regulation and interplay with aryl hydrocarbon receptor.
Brauze D
J Appl Genet, 2021,62: 99-105, Epub 2021 Jan 2, doi.org/10.1007/s13353-020-00606IF-2,027 MNiSW-100
All publications
Featured research projects
1. Project OPUS
„Genome-wide mutation screen of the regulome in laryngeal squamous cell carcinoma.”
Duration: 2017-2020
2. Project PRELUDIUM
„Role of miR-299-5p in pathogenesis of laryngeal squamous cell carcinoma.”
Duration: 2017-2020
3. Project OPUS
“The expression analysis of genes and proteins potentially involved in lymph node metastasis formation in laryngeal cancer”
Duration: 2016-2019
4. Project HARMONIA
“Identification of miRNAs involved in classical Hodgkin lymphoma pathogenesis using combined expression and mutation profiling and functional analyses.”
Duration: 2015-2018
5. Project HARMONIA
“Whole exome sequencing in Polish patients with sporadic keratoconus and a pilot study of keratoconus proteomic and metabolomic profiles of tears.”
Duration: 2014-2017
Collaborations
Department of Otolaryngology, Poznan University of Medical Sciences, Poznań, Poland.
Institute of Human Genetics, Christian Albrecht University, Kiel, Germany.
Institute of Cell Biology (Tumour Research), University Duisburg-Essen, Germany.
Senckenberg Institute of Pathology, Goethe University Frankfurt, Germany.
Department of Otorhinolaryngology – Head and Neck Surgery, University of Turku, Finland.
Department of Molecular and Human Genetics, Baylor College of Medicine Houston, TX, USA.
Awards
Awarded:
dr n. med. Joanna Świerkowska
Nomination for the Polish Intelligent Development Award 2020
Given by: Polish Intelligent Development
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: Rola metylacji DNA w etiologii wysokiej krótkowzroczności u polskich dzieci".
Awarded:
dr hab. n. med. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr n. med. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
dr hab. n. med. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr n. med. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
Award of the Division of Medical Sciences of the Polish Academy of Sciences
Given by: Division of Medical Sciences of the Polish Academy of Sciences
for 5 publications concerning loss of tumor suppressor genes in squamous cell carcinoma
Awarded:
dr n. med. Joanna Świerkowska
EMBO Short-term fellowship
Given by: EMBO
Joanna Świerkowska from the Department of Cancer Genetics received an EMBO short-term fellowship for the implementation of the project “The role of the noncoding miRNA and enhancers in high myopia” at Erasmus Medical Center, Rotterdam, The Netherlands
Awarded:
dr n. med. Magdalena Kostrzewska-Poczekaj
EMBO short-term fellowship
Given by: EMBO
Magdalena Kostrzewska-Poczekaj from the Department of Cancer Genetics received an EMBO short-term fellowship for the implementation of the project "Platelets and platelet microparticles (PMP) as omnipresent RNA messengers in inflammatory diseases" at University Hospital Schleswig Holstein, Clinic for Otorhinolaryngology - Head and Neck Surgery, Luebeck in Germany.
Awarded:
dr hab. n. med. Maciej Giefing
Powołanie na członka Rady Naukowej Instytutu Genetyki Człowieka PAN w Poznaniu na kadencję 2019-2022.
Given by: Rada Naukowa Instytutu Genetyki Człowieka PAN
Awarded:
prof. dr hab. n. med. Marzena Gajęcka
Kosciuszko Foundation Fellowship
Given by: Kosciuszko Foundation
Prof. Marzena Gajecka has been awarded a Kosciuszko Foundation Fellowship for the academic year 2019/2020, to visit Baylor College of Medicine and Texas Children’s Hospital in Houston, TX, US. The Kosciuszko Foundation promotes closer ties between Poland and the United States through educational, scientific and cultural exchanges. The Kosciuszko Foundation annually awards a number of Fellowships/Grants to Poles for advanced study, research, and/or teaching at universities and other institutions of higher learning in the United States.
Awarded:
mgr Adam Ustaszewski
Msc Adam Ustaszewski otrzymał stypendium międzynarodowe (Short-Term Fellowship) przyznane przez Europejską Organizację Biologii Molekularnej (EMBO)
Given by: European Molecular Biology Organization (EMBO).
Mgr Adam Ustaszewski otrzymał stypendium międzynarodowe (Short-Term Fellowship) przyznane przez Europejską Organizację Biologii Molekularnej (EMBO) na projekt badawczy zatytułowany „Identification of putative alternations of open chromatin regions in Classical Hodgkin Lymphoma by integration of ATAC-Seq and high-throughput sequencing of cis-regulatory elements.”, przyznane przez Europejską Organizację Biologii Molekularnej (EMBO). Poznań. 24.01.2019 r.
Awarded:
mgr inż. Ewelina Kowal-Wiśniewska
Master’s thesis Award
Given by: Poznań University of Life Sciences
MSc. eng. Ewelina Kowal from the Departament of Cancer Genetics was awarded the Professor Jerzy Zwoliński first degree prize in the competition for the best master’s thesis written in the academic year 2017/2018 at the Poznan University of Life Sciences. Supervisor: Małgorzata Jarmuż-Szymczak, PhD Associate Professor.
Awarded:
mgr Adam Ustaszewski
Given by: Organizing committee 18th International Congress of Young Medical Scientists.
The oral presentation entitled 'Germline mutations in ALDH3A1 and RMDN2 genes as potential factors in salivary gland tumor development' received a distinction during 18th International Congress of Young Medical Scientists, Poznan, 14-16.06.2018 r.
Awarded:
mgr inż. Ewelina Kowal-Wiśniewska
mgr Adam Ustaszewski
dr n. med. Katarzyna Kiwerska
mgr Julia Paczkowska
dr hab. n. med. Małgorzata Jarmuż-Szymczak
mgr inż. Ewelina Kowal-Wiśniewska
mgr Adam Ustaszewski
dr n. med. Katarzyna Kiwerska
mgr Julia Paczkowska
dr hab. n. med. Małgorzata Jarmuż-Szymczak
First prize for the poster
Given by: II Ogólnopolskie Sympozjum Nauk Rolniczo-Przyrodniczych
First prize for the poster “Targeted next generation sequencing of selected genes in patients with myelodysplastic syndromes” (Kowal E, Kiwerska K, Ustaszewski A, Paczkowska J, Adamska M, Czerwińska- Rybak J, Komarnicki M, Gil L, Jarmuż-Szymczak M), II Ogólnopolskie Sympozjum Nauk Rolniczo-Przyrodniczych, Poznań 7-8.04.2018.