Our scientific interests concentrate on cancer genetics and the genetics of the senses. We use various techniques in our routine practice, from molecular biology and cytogenetics (microarrays, NGS, pyrosequencing, FISH and FICTION) supplemented by functional analyses. The aim of the research is the identification of genomic and epigenomic alterations that contribute to the development of neoplasms and diseases of the sensory organs. To that end, we work closely with renowned Polish and foreign scientific groups.
Department of Cancer Genetics
Featured publications
Loss of function mutations of BCOR in classical Hodgkin lymphoma.
Giefing M, Gearhart MD, Schneider M, Overbeck B, Klapper W, Hartmann S, Ustaszewski A, Weniger MA, Wiehle L, Hansmann ML, Melnick A, Beguelin W, Sundrom Ch, Kuppers R, Bardwell VJ, Siebert R
Leukemia and Lymphoma, 2022, 63 (5): 1080-1090, doi: 10.1080/10428194.2021.2015587IF-3,280 MNiSW-70
Maternal serum proteomic profiles of pregnant women with type 1 diabetes.
Gutaj P, Matysiak J, Matuszewska E, Jaśkiewicz K, Kamińska D, Swiatły-Błaszkiewicz A, Szczapa T, Kalantarova A, Gajęcka M, Wender-Ożegowska E
Sci Rep, 2022, 12: 8696, doi: 1038/s41598-022-12221-5IF-4,380 MNiSW-140
Global DNA methylation profiling reveals differentially methylated CpGs between salivary gland pleomorphic adenomas with distinct clinical course.
Kiwerska K, Kowal-Wiśniewska E, Ustaszewski A, Bartkowiak E, Jarmuż-Szymczak M, Wierzbicka M, Giefing M
IF-5,924 MNiSW-140
The Narrow Band Imaging as an essential complement to White Light Endoscopy in Recurrent Respiratory Papillomatosis diagnostics and follow up process. Obrazowanie wąskopasmowe (NBI) – niezbędne uzupełnienie endoskopii światłem białym w diagnostyce i obserwacji nawracającej brodawczakowatości układu oddechowego.
Klimza H, Jackowska J, Pietruszewska W, Rzepakowska A, Wierzbicka M (artykuł dwujęzyczny)
Otolaryngol Pol, 2022, 76 (1): 1-5, Epub 2021 Oct 28, doi: doi: 10.5604/01.3001.0015.4540; doi: 10.5604/01.3001.0015.454MNiSW-100
The holmium:YAG laser lithotripsy - a non-invasive tool for removal of midsize stones of major salivary glands.
Kałużny J, Klimza H, Tokarski M, Piersiala K, Witkiewicz J, Katulska K, Wierzbicka M
Lasers Med Sci, 2022 Febr, 37 (1): 163-169, Epub 2020 Nov 21, doi: 10.1007/s10103-020-03201-0IF-3,161 MNiSW-70
Congenital amusia—pathology of musical disorder.
Szyfter K, Wigowska-Sowińska J
J Appl Genetics, 2022 Febr, 63 (1): 119-126, Epub 2021 Sept 21, doi: 10.1007/s13353-021-00662-zIF-3,240 MNiSW-100
Przyczyny wystąpienia choroby Meniere’a w świetle najnowszych danych literaturowych.
Dąbrowski P, Szyfter K
Post Chirurgii Głowy i Szyi, 2/2021, 20 (2), 17-21.MNiSW-20
New geneteic variants of TET2 and ASXL1 identified by next generation sequencing and pyrosequencing in a patient with MDS-RS-MLD and secondary acute myeloid leukemia.
Adamska MM, Kowal-Wiśniewska E, Kiwerska K, Ustaszewski A, Czerwińska-Rybak J, Kanduła Z, Wojtaszewska M, Barańska M, Pruchniewski Ł, Lewandowski K, Jarmuż-Szymczak M
Central Eur J Immunol, 2021, 46, 4: 1-6, 524-530. doi: 10.5114/ceji.2021.111166IF-2,085 MNiSW-70
Alginate and pectin films covering halloysite with encapsulated salicylic acid as food packaging components.
Kurczewska J, Ratajczak M, Gajecka M
IF-5,467 MNiSW-100
Alteration of the Early Development Environment by Maternal Diet and the Occurrence of Autistic-like Phenotypes in Rat Offspring.
Gawlińska K, Gawliński D, Kowal-Wiśniewska E, Jarmuż-Szymczak M, Filip M
Int J Mol Sci (MDPI), 2021, 22 (18): 9662;19 stron, https://doi.org/10.3390/ijms22189662IF-5,923 MNiSW-140
All publications
Featured research projects
1. Project OPUS
„Genome-wide mutation screen of the regulome in laryngeal squamous cell carcinoma.”
Duration: 2017-2020
2. Project PRELUDIUM
„Role of miR-299-5p in pathogenesis of laryngeal squamous cell carcinoma.”
Duration: 2017-2020
3. Project OPUS
“The expression analysis of genes and proteins potentially involved in lymph node metastasis formation in laryngeal cancer”
Duration: 2016-2019
4. Project HARMONIA
“Identification of miRNAs involved in classical Hodgkin lymphoma pathogenesis using combined expression and mutation profiling and functional analyses.”
Duration: 2015-2018
5. Project HARMONIA
“Whole exome sequencing in Polish patients with sporadic keratoconus and a pilot study of keratoconus proteomic and metabolomic profiles of tears.”
Duration: 2014-2017
Collaborations
Department of Otolaryngology, Poznan University of Medical Sciences, Poznań, Poland.
Institute of Human Genetics, Christian Albrecht University, Kiel, Germany.
Institute of Cell Biology (Tumour Research), University Duisburg-Essen, Germany.
Senckenberg Institute of Pathology, Goethe University Frankfurt, Germany.
Department of Otorhinolaryngology – Head and Neck Surgery, University of Turku, Finland.
Department of Molecular and Human Genetics, Baylor College of Medicine Houston, TX, USA.
Awards
Awarded:
dr n. med. Julia Paczkowska
IX Edition of the Competition of the Polish Academy of Sciences in Poznan for the best scientific publication, which was published in 2020 and the lead author was a PhD student.
Given by: Polish Academy of Sciences in Poznan
Dr Julia Paczkowska – lauerate of the IX Edition of the Competition of the Polish Academy of Sciences in Poznan for the best scientific publication, which was published in 2020 and the lead author was a PhD student.
Awarded:
dr n. med. Joanna Świerkowska
Nomination for the Polish Intelligent Development Award 2020
Given by: Polish Intelligent Development
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: Rola metylacji DNA w etiologii wysokiej krótkowzroczności u polskich dzieci".
Awarded:
dr hab. n. med. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr n. med. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
dr hab. n. med. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr n. med. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
Award of the Division of Medical Sciences of the Polish Academy of Sciences
Given by: Division of Medical Sciences of the Polish Academy of Sciences
for 5 publications concerning loss of tumor suppressor genes in squamous cell carcinoma
Awarded:
dr n. med. Joanna Świerkowska
EMBO Short-term fellowship
Given by: EMBO
Joanna Świerkowska from the Department of Cancer Genetics received an EMBO short-term fellowship for the implementation of the project “The role of the noncoding miRNA and enhancers in high myopia” at Erasmus Medical Center, Rotterdam, The Netherlands
Awarded:
dr n. med. Magdalena Kostrzewska-Poczekaj
EMBO short-term fellowship
Given by: EMBO
Magdalena Kostrzewska-Poczekaj from the Department of Cancer Genetics received an EMBO short-term fellowship for the implementation of the project "Platelets and platelet microparticles (PMP) as omnipresent RNA messengers in inflammatory diseases" at University Hospital Schleswig Holstein, Clinic for Otorhinolaryngology - Head and Neck Surgery, Luebeck in Germany.
Awarded:
dr hab. n. med. Maciej Giefing
Powołanie na członka Rady Naukowej Instytutu Genetyki Człowieka PAN w Poznaniu na kadencję 2019-2022.
Given by: Rada Naukowa Instytutu Genetyki Człowieka PAN
Awarded:
prof. dr hab. n. med. Marzena Gajęcka
Kosciuszko Foundation Fellowship
Given by: Kosciuszko Foundation
Prof. Marzena Gajecka has been awarded a Kosciuszko Foundation Fellowship for the academic year 2019/2020, to visit Baylor College of Medicine and Texas Children’s Hospital in Houston, TX, US. The Kosciuszko Foundation promotes closer ties between Poland and the United States through educational, scientific and cultural exchanges. The Kosciuszko Foundation annually awards a number of Fellowships/Grants to Poles for advanced study, research, and/or teaching at universities and other institutions of higher learning in the United States.
Awarded:
mgr Adam Ustaszewski
Msc Adam Ustaszewski otrzymał stypendium międzynarodowe (Short-Term Fellowship) przyznane przez Europejską Organizację Biologii Molekularnej (EMBO)
Given by: European Molecular Biology Organization (EMBO).
Mgr Adam Ustaszewski otrzymał stypendium międzynarodowe (Short-Term Fellowship) przyznane przez Europejską Organizację Biologii Molekularnej (EMBO) na projekt badawczy zatytułowany „Identification of putative alternations of open chromatin regions in Classical Hodgkin Lymphoma by integration of ATAC-Seq and high-throughput sequencing of cis-regulatory elements.”, przyznane przez Europejską Organizację Biologii Molekularnej (EMBO). Poznań. 24.01.2019 r.
Awarded:
mgr inż. Ewelina Kowal-Wiśniewska
Master’s thesis Award
Given by: Poznań University of Life Sciences
MSc. eng. Ewelina Kowal from the Departament of Cancer Genetics was awarded the Professor Jerzy Zwoliński first degree prize in the competition for the best master’s thesis written in the academic year 2017/2018 at the Poznan University of Life Sciences. Supervisor: Małgorzata Jarmuż-Szymczak, PhD Associate Professor.
Awarded:
mgr Adam Ustaszewski
Given by: Organizing committee 18th International Congress of Young Medical Scientists.
The oral presentation entitled 'Germline mutations in ALDH3A1 and RMDN2 genes as potential factors in salivary gland tumor development' received a distinction during 18th International Congress of Young Medical Scientists, Poznan, 14-16.06.2018 r.