Lecture
Human Genome Evolution and Variability in Health and Disease
winter semester 2026/2027
(This lecture is obligatory)
Lecturer coordinator: prof. dr hab. Jadwiga Jaruzelska
| Data | Temat |
|
14.10.2026 |
Mechanisms shaping the genetic variability (2h) (prof. dr hab. Ewa Ziętkiewicz) |
|
28.10.2026 |
Selection and demography in shaping population profiles (2h) (prof. dr hab. Ewa Ziętkiewicz) |
| 18.11.2026 9:30 -11:00 |
Mobile elements in the human genome (2h) (dr hab. Zbigniew Warkocki) |
| 25.11.2026 9:30 -11:00 |
Genetic variability in non-coding sequences in the human genome (2h) (dr hab. Agnieszka Dzikiewicz-Krawczyk |
| 02.12.2026 9:30 -11:00 |
Mitochondrial haplogroups (1h) Evolution and pathology of sex chromosomes (1h) |
| 16.12.2026 9:30 -11:00 |
Genetic epidemiology in forensic studies (1h) Analysis of human intestinal microbiota (1h) |
| 06.01.2026 9:30 -11:00 |
Evolution of Homo sapiens in light of genetic studies (2 h) (prof. dr hab. Ewa Ziętkiewicz) |
| 13.01.2026 9:30 -11:00 |
Genetic epidemiology in medical studies (2h) (dr Patrycja Daca-Roszak) |
| 27.01.2026 9:30 -11:00 |
Genetic variability and cell function in health and disease part 1 (2h) (dr Monika Drobna-Śledzińska) |
| 03.02.2026 9:30 -11:00 |
Genetic variability and cell function in health and disease part 2 (2h) (dr hab. Zuzanna Bukowy-Bieryłło) |
SYLLABUS
winter semester 2026/2027
Lectures will be held on Wednesday starting on 14 October 2026 in lecture hall of the Institute of Human Genetics Polish Academy of Sciences
| Course |
Human Genome Evolution and Variability in Health and Disease |
| Host Institution | Institute of Human GeneticsPolish Academy of SciencesStrzeszyńska Street, 32 |
| Language | English |
| The expected effects of teaching in terms of: knowledge, skills and social qualifications |
Ph. D. student is supposed to: 1.Gain knowledge in several aspects of human genome variability and its significance in human health and disease. In particular, the following specific topics will be elaborated: -Mechanisms shaping the genetic variability -Evolution of sex chromosomes -Selection and demography in shaping genetic diversity profiles -History of genes and history of populations -Mobile elements in the human genome -Evolution of Homo sapiens -Genetic epidemiology in medical studies -Genetic variability of the cell function in health and disease -human intestinale microbiome
3. To learn how to formulate scientific questions related to human genome variability in health and disease |
| Type of course | obligatory |
| Semester/year | winter semester 2026/2027 |
| First name/family name of the person responsible for the course | prof. dr hab. Jadwiga Jaruzelska |
| First name/family name of the person responsible for the exam | prof. dr hab. Jadwiga Jaruzelska |
| Format | Lecture will be held in English with usage of audio-visual equipment. |
| Basic and additional requirements | Skills in English and knowledge in molecular biology |
| Number of ECTSs | 3 ECTS |
| ECTSs summary | 1 ECTS corresponds to 25-30 hours of personal studies focused on broadening knowledge based on suggested bibliography (vide bibliography list below). |
| Method of teaching | The course is conducted in an interactive format with active participation of PhD students |
| Method of evaluation | written exam |
| Prerequisite for passing |
positive score at the exam |
| Topics |
Mechanisms how genetic variability arises and how it spreads within populations -Evolution of sex chromosomes -History of genes and history of populations -Role of selection in creating genetic diversity profiles -Diversity of the human genome -Diversity of repetitive elements within the genome -Evolution of Homo sapiens in the context of genetic diversity in the modern human populations -Practical applications of genomic diversity -Some aspects of genetic bases of functional modulation of the cell in health and disease -Mechanisms and factors shaping the genetic variability -Evolution of sex chromosomes -History of genes and history of populations -Role of selection and demography in shaping genetic diversity profiles -Evolution of the human genome -Repetitive elements in the human genome -Evolution of Homo sapiens in light of the genetic diversity in modern human populations -Genetic epidemiology in medical and forensic studies -Genetic bases of the variability of the cell function in health and disease -human intestinal microbiome in health and disease |
| Additional material |
Presentation of each lecture in PDF format Bibliography related to each lecture |
| Bibliography |
LL Cavalli-Sforza & Bodmer The Genetics of Human Populations. Dover Publications (2013) ES Tobias, M Connor & M Ferguson-Smith. Essential Medical GeneticsEssential Medical Genetics. Wiley-Blackwell (2011). DL Hartl & AG Clark. Principles of population genetics. Sinauer Associates (2006) KR Veeramah & MF Hammer. The impact of whole-genome sequencing on the reconstruction of human population history. Nature Reviews| Genetics 15:149-161 (2014). S Eggers & A Sinclair. Mammalian sex determination—insights from humans and mice. Chromosome Research 20:215–238 (2012). BJ Lesch and DC Page. Genetics of germ cell development. Nature Reviews Genetics 13:781-794 (2012). N Naidoo, Y Pawitan, R Soong, DN Cooper and CS Ku. Human genetics and genomics a decade after the release of the draft sequence of the human genome. Human Genomics. 5:577–622 (2011). MM Matzuk & DJ Lamb. The biology of infertility: research advances and clinical challenges. Nature Medicine 14:1197-1213 (2008). N Powles-Glover. Cilia and ciliopathies: Classic examples linking phenotype and genotype: An overview. Reproductive Toxicology 48:98–105 (2014). Zietkiewicz, Witt, Daca, Żebracka-Gala, Goniewicz, Jarząb & Witt. Current genetic methodologies in the identification of disaster victims and in forensic analysis. J Appl Genetics 53:41–60 (2012). |