The Department of Nucleic Acid Function conducts research related to the genetics of the molecular diagnostics of familial colorectal polyposis (FAP) and medullary thyroid cancer. Our research also focuses on the genes involved in osteoporosis, Crohn's disease, Alzheimer's disease, frontotemporal dementia, aortic aneurysm and spermatogenesis. The department has also been working in the field of biotechnology on transgenic animals for biomedical applications.
Department of Nucleic Acid Function
Featured publications
Assessing Fluorosis Incidence in Areas with Low Fluoride Content in the Drinking Water, Fluorotic Enamel Architecture, and Composition Alterations.
Strużycka I, Olszewska A, Bogusławska-Kapała A, Hryhorowicz S, Kaczmarek-Ryś M, Grabarek BO, Staszkiewicz R, Kuciel-Polczak I, Czajka-Jakubowska A
Int J Environ Res Public Health (MDPI), 2022 Jun 10;19 (12): 7153, 12 stron. doi: 10.3390/ijerph19127153IF-3,390 MNiSW-140
Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review.
Krela-Kaźmierczak I, Zakerska-Banaszak O, Skrzypczak-Zielińska M, Łykowska-Szuber L, Szymczak-Tomczak A, Zawada A, Rychter AM, Ratajczak AE, Skoracka K, Skrzypczak D, Marcinkowska E, Słomski R, Dobrowolska A
Nutrients (MDPI), 2022, 14 (12), 252, 28 str, doi/10.3390/nu14122520IF-5,719 MNiSW-140
Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity - A narrative review.
Rychter AM, Hryhorowicz S, Słomski R, Dobrowolska A, Krela-Kaźmierczak I
Clinical Nutrition, 2022 May 6, 41 (7):1557-1565. doi: 10.1016/j.clnu.2022.04.032IF-7,235 MNiSW-140
Distinct Roles of NANOS1 and NANOS3 in the Cell Cycle and NANOS3‐PUM1‐FOXM1 Axis to Control G2/M Phase in A Human Primordial Germ Cell Model.
Ilaslan E, Kwiatkowska K, Śmialek MJ, Sajek MP, Lemańska Ż, Alla M, Janecki DM, Jaruzelska J, Kusz‐Zamelczyk K
Int J Molec Sci (MDPI), 2022, 23 (12): 6592, 19 str, https://doi.org/10.3390/ijms23126592IF-5,924 MNiSW-140
Basal Cell Carcinoma: Pathology, Current Clinical Treatment, and Potential Use of Lipid Nanoparticles.
Łasińska I, Zielińska A, Mackiewicz J, Souto EB
Cancers (MDPI), 2022, 14 (11): 2778, 14 stron. https://doi.org/10.3390/cancers14112778IF-6,639 MNiSW-140
Non-melanoma skin cancers: physio-pathology and role of lipid delivery systems in new chemotherapeutic treatments.
Souto EB,Ana R, Vieira V, Fangueiro JF, Cano A, Dias-Ferreira J, Cano A, Zielińska A, Silva AM, Staszewski R, Karczewski J
Neoplasia, 2022 August, 30 C, 100810, 15 str, Epub 2022 May 29, https://doi.org/10.1016/j.neo.2022.100810IF-5,715 MNiSW-140
Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol.
Zielińska A, Cano A, Andreani T, Martins-Gomes C, Silva M, Szalata M, Słomski R, Souto EB
Int J Molec Sci (MDPI), 2022, 23 (11): 6165, 14 str, https://doi.org/10.3390/ijms23116165IF-5,924 MNiSW-140
Obesity and the Brain.
Karczewski J, Zielińska A, Staszewski R, Eder P Dobrowolska A, Souto EB
Int J Molec Sci (MDPI), 2022, 23 (11), 6145, 30 str. https://doi.org/10.3390/ijms23116145IF-5,924 MNiSW-140
Risk assessment of injectable nanoparticles used as nanomedicine.
Chaud MV, Batain F, Sauto EB, SEverino P, Zielińska A, Alves TFR
W: Nanotechnology in Medicine: Toxicity and Safety, 2022, First Edition, ed by Mahendra Rai, Mrunali Patel and Rashmin Patel. John Wiley and Sons Ltd. Print ISBN:9781119769866, Online ISBN:9781119769897, Chapter 11, str. 248-258, doi: 10.1002/9781119769897.MNiSW-80
NOD2c.3019-3020insC AND c.2104C>T gene variants among patients from Western Ukraine with Crohn’s disease and colorectal cancer.
Lozynska L, Pinyazhko R, Lozynska M, Pławski A, Makukh H, Lukavetskyy O, Grzegotsky M, Pinyazhko O
Exp Oncol, 2022 May;44 (1): 52-59, doi: 10.32471/exp-oncology.2312-8852.vol-44-no-1.17305.MNiSW-40
All publications
Featured research projects
1. Acronym MEDPIG, INNOMED/I/17/NCBR/2014
“Development of an innovative technology for using transgenic pig tissues for biomedical purposes”
Task no 5. Development and characterization of new gene construct for transgenesis.
Obtained financial support from the National Centre for Research and Development from the funds of the Operational Programme Innovative Economy within the framework of the European Regional Development Fund.
Agreement no INNOMED 1/20106/07/2013/6
Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2014-2017
2. Acronym ONKOKAN, INNOMED/I/11/NCBR/2014
“Development of technology for obtaining cannabinoids from hemp with low THC content as agents supporting treatment for cancer patients”
Task no 7. Assessment of genetic polymorphisms and genes expression involved in the metabolism of cannabinoids and response to their application in the Polish population
Agreement no INNOMED 1/20104/07/2013/7
Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2014-2017
3. “Sharing Advances on Large Animal Models (SALAAM)”
COST Action BM1308. Management Committee Member.
Coordinator Prof. Eckhard Wolf (Germany)
http://www.salaam.genzentrum.lmu.de
http://www.cost.eu/COST_Actions/bmbs/Actions/BM1308
MC member – prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Duration of the project: 19.05.2014-18.05.2018
4. UDA/POIG.01.04.00-24-002/11-00
Operational Programme Innovative Economy 2007-2013 under Measure 1.4 Support for special projects of priority axis 1 Research and development of new technologies. „Development studies on efficient technology of production fluid into renal transplantation,
Project leader: Prof. dr hab. n. med. Florian Ryszka, Pharmaceutical Research and Production Plant „BIOCHEFA”
Research task „Development of the methodology to determine the zygosity of pigs for xenotransplantation of kidney and reproducible animal model”
Task leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2012-2013
5. Ministry of Science and Higher Education N N303 457238
“Investigation of the degree of genetic determination in prenatal testing – analysis of genetic variability in twins”
Project leader : prof. dr hab. Krystyna Cieślik, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2010-2014
6. Ministry of Science and Higher Education N N401 037838
“Analysis of gene polymorphisms influenced on reaction to anaesthetics in patients under general anaesthesia and on reaction to analgetics in the postoperative period”
Project leader : dr Adam Mikstacki, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2010-2014
7. Development project N R13 0018 06
„Inhibition of the activation of the coagulation system and systemic inflammatory response during extracorporeal respiratory support in an animal model”
Project leader : dr Wiesław Zygmunt Królikowski, CM UJ
Task: Analysis of genetic variability of pigs for somatic cloning and xenotransplantation .
Task leader: prof. dr hab. Z. Smorąg, współpraca prof. R. Słomski
Duration of the project: 2009-2012
8. Development project N R13 0075 06/2009
„Transgenic bioprosthetic heart valves based on the tissue engineering techniques”
Project leader: dr hab. Romuald Antoni Cichoń, Foundation of Cardiac Surgery Development in Zabrze
Task: Molecular and cytogenetic characterization of potentially transgenic pigs
Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2012
9. Development project N R12 0036 06/2009
„Obtaining transgenic pigs as donors of tissues and organs for transplantation in humans and their biotechnological, medical and physiological characteristics”
Project leader : prof. dr hab. Z. Smorąg, IZ-PIB
Task no 5. Molecular and cytogenetic characteristics of the transgenic pigs and evaluation of transgene expression at the level of transcription and translation.
Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2013
10. Ministry of Science and Higher Education N N402 471437
“Comparison of genetic basis of abdominal aortic aneurysm and aortoiliac occlusive disease based on the association analysis of gene polymorphisms of selected metalloproteinases and their inhibitors”
Project leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2012
11. ERIN no.: 227750
“Support study for the identification of potential needs and possibilities for an integrated European infrastructure network of animal facilities in ruminant physiology and breeding”
Project leader: prof. dr hab. Z. Smorąg, cooperation: prof. R. Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 18 months, 2008-2010
12. Ministry of Science and Higher Education N N403 209635
“Association analysis of selected gene polymorphisms and abdominal aortic aneurysm oraortoiliac occlusive disease”
Project leader: dr hab. Marcin Gabriel, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2010
13. Ministry of Science and Higher Education N N402 209835
“Genetic factors involved in the reaction to thiopurine drugs in patients with inflammatory bowel disease”
Project leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2012
14. Ministry of Science and Higher Education N N401 014435
„Genetic basis of selected hamartoma polyposis syndroms”
Supervisor of the project : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2010
15. Ministry of Science and Higher Education N N402 287436
“Association analysis of polymorphisms of selected genes with the risk of differentiated thyroid cancer, clinical course and response to treatment ”
Supervisor of the project: mgr Marta Kaczmarek, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2011
Collaborations
Poznań University of Life Sciences, Department of Biochemistry and Biotechnology, Poland.
National Research Institute of Animal Production in Balice, Poland.
Poznań University of Medical Sciences, Poland.
Foundation of Cardiac Surgery Development, Poland.
Burns Treatment Centre in Siemianowice Śląskie, Poland.
Laboratory of Molecular Genetics in Poznań, Poland.
Institute of Natural Fibres and Medicinal Plants, Poland.
PozLab sp. z o.o. (Ltd), Poland.
Adam Mickiewicz University in Poznań, NanoBioMedical Centre, Poland.
Awards
Nagroda im. Prof. W. Bielańskiego przyznana przez Towarzystwo Biologii Rozrodu za dwa powiązane ze sobą artykuły oryginalne opublikowane w 2020 roku.
za dwa powiązane ze sobą artykuły oryginalne opublikowane w 2020 roku.
Head of Local Self-Parliament
Prof. Krzysztof Szyfter was awarded by Marek Woźniak, the Head of Local Self-parliament for his merits to Great-Poland District.
prof. dr hab. n. biol. Jadwiga Jaruzelska
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
Award of the Faculty of Medical Sciences of the Polish Academy of Sciences
Prof. Jadwiga Jaruzelska, dr Marcin Piotr Sajek, dr Maciej Jerzy Śmiałek and Ms Erkut Ilaslan were awarded by Medical Division of the Polish Academy of Sciences for 5 articles entitled: “Role of NANOS and PUM proteins in human reproduction and infertility”.
Prize of the Prime Minister of the Republic of Poland
Dr Maciej Jerzy Śmiałek was awarded a Prize of the Prime Minister of the Republic of Poland for his PhD dissertation „A global identification of mRNAs regulated by PUM1 and PUM2 and their protein cofactors, in the model of human seminoma (TCam-2)”defended in 2020.
FNP START 2021 Program.
Dr Aleksandra Zielińska from the Department of Nucleic Acids Function of our Institute has become a laureate of the FNP START 2021 Program.
Officer's Cross of the Order of Polonia Restituta.
Prof. dr hab. n. med. Ryszard Słomski was decorated with the Officer's Cross of the Order of Polonia Restituta. The ceremony took place on June 7, 2021 at the Wielkopolska Voivodship Office in Poznań. The Cross was awarded by the President of the Republic of Poland, Andrzej Duda, on the Professor's 70th birthday. Due to the pandemic, the handing over was delayed by a year and a half. The Order was awarded for the Professor's scientific and research activities, including pioneering DNA studies in the country for diagnostic, medical and forensic purposes, as well as the implementation and dissemination of molecular diagnostics (DNA fingerprinting 1987; PCR polymerase chain reaction 1989). Works in the field of medical biotechnology constitute an important field of interest and include obtaining of transgenic animals as bioreactors for the production of peptides and tissues for xenotransplantation. Biological dressings made of the skin of transgenic pigs have been used many times in the Burn Treatment Center in Siemianowice Śląskie.
Dr hab. Anna Kowalska received the scientific team award of the Rector of Poznan Karol Marcinkowski University of Medical Sciences awarded to a team consisting of: Dr hab. Zuzanna Ślebioda, Prof. dr hab. Barbara Dorocka-Bobkowska, Dr hab. Anna Kowalska.
for a series of 7 papers on selected genetic aspects and systemic conditions accompanying chronic recurrent aphthous stomatitis
Dinstinction
Distinction in the contest for the best poster presentation in Gliwice Scientific Meeting 2020: Identification of irradiation-induced ATM-dependent IncRNAs
Scholarship
Scholarship 2020/21
The Professor W. Bielański award
For two related original articles published in 2020.