About Publications Research projects Collaborations Awards

Department of Nucleic Acid Function

The Department of Nucleic Acid Function conducts research related to the genetics of the molecular diagnostics of familial colorectal polyposis (FAP) and medullary thyroid cancer. Our research also focuses on the genes involved in osteoporosis, Crohn's disease, Alzheimer's disease, frontotemporal dementia, aortic aneurysm and spermatogenesis. The department has also been working in the field of biotechnology on transgenic animals for biomedical applications.

Keywords:
  • DNA
  • genetic engineering
  • genotyping
  • Molecular diagnostics
  • PCR
  • RNA
  • sequencing

Featured publications

Biotechnologia 2020. O co najczęściej pytamy?

Biotechnologia 2020. O co najczęściej pytamy?
Red. Szalata M, Słomski R, Twardowski T, Wyd. Uniwersytetu Przyrodniczego w Poznaniu, Oddział Polskiej Akademii Nauk w Poznaniu, ISBN 978-83-7160-982-4 /autorzy: Cieślak D, Cłapa T, Gronek P, Kolanowski T, Lenik-Kwapich E, Narożna D, Słomski R, Szalata M, Twardowski T/, 256 str.

Wyd. Uniwersytetu Przyrodniczego w Poznaniu, Oddział Polskiej Akademii Nauk w Poznaniu, ISBN 978-83-7160-982-4, 256 str.

MNiSW-80

Antimicrobial peptides and their bactericidal, immunomodulating and anticancer activities – a literature mini-review.
Kowalska A, Walter de Walthoffen Sz, Durska E
Rozdz. monografii „Advances in Biomedical Research – from Cancer Prevention to Treatment”, red. Izabela Młynarczuk-Biały, Łukasz Biały, Wydawnictwo Nauk. TYGIEL + WUM, Lublin 31.12.2020. ISBN: 978-83-66489-45-5, str. 182-196

MNiSW-20

Featured research projects

1. Acronym MEDPIG, INNOMED/I/17/NCBR/2014

“Development of an innovative technology for using transgenic pig tissues for biomedical purposes”

Task no 5. Development and characterization of new gene construct for transgenesis.

Obtained financial support from the National Centre for Research and Development from the funds of the Operational Programme Innovative Economy within the framework of the European Regional Development Fund.

Agreement no INNOMED 1/20106/07/2013/6

Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University

Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2014-2017

2. Acronym ONKOKAN, INNOMED/I/11/NCBR/2014

“Development of technology for obtaining cannabinoids from hemp with low THC content as agents supporting treatment for cancer patients”

Task no 7. Assessment of genetic polymorphisms and genes expression involved in the metabolism of cannabinoids and response to their application in the Polish population

Agreement no INNOMED 1/20104/07/2013/7

Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University

Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2014-2017

4. UDA/POIG.01.04.00-24-002/11-00

Operational Programme Innovative Economy 2007-2013 under Measure 1.4 Support for special projects of priority axis 1 Research and development of new technologies. „Development studies on  efficient technology of production fluid into renal transplantation,

Project leader: Prof. dr hab. n. med. Florian Ryszka, Pharmaceutical Research and Production Plant „BIOCHEFA”

Research task „Development of the methodology to determine the zygosity of pigs for xenotransplantation of kidney and reproducible animal model”

Task leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2012-2013

5. Ministry of Science and Higher Education N N303 457238

“Investigation of the degree of genetic determination in prenatal testing – analysis of genetic variability in twins”

Project leader : prof. dr hab. Krystyna Cieślik, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2010-2014

6. Ministry of Science and Higher Education N N401 037838

“Analysis of gene polymorphisms influenced on reaction to anaesthetics in patients under general anaesthesia and on reaction to analgetics in the postoperative period”

Project leader : dr Adam Mikstacki, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland

Duration of the project: 2010-2014

7. Development project N R13 0018 06

„Inhibition of the activation of the coagulation system and systemic inflammatory response during extracorporeal respiratory support in an animal model”

Project leader :  dr Wiesław Zygmunt Królikowski, CM UJ

Task: Analysis of genetic variability of pigs for somatic cloning and xenotransplantation .

Task leader: prof. dr hab. Z. Smorąg, współpraca prof. R. Słomski

Duration of the project:  2009-2012

8. Development project N R13 0075 06/2009

„Transgenic bioprosthetic heart valves based on the tissue engineering techniques”

Project leader: dr hab. Romuald Antoni Cichoń, Foundation of Cardiac Surgery Development in Zabrze

Task: Molecular and cytogenetic characterization of potentially transgenic pigs

Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project:  2009-2012

9. Development project N R12 0036 06/2009

„Obtaining transgenic pigs as donors of tissues and organs for transplantation in humans and their biotechnological, medical and physiological characteristics”

Project leader : prof. dr hab. Z. Smorąg, IZ-PIB

Task no 5. Molecular and cytogenetic characteristics of the transgenic pigs and evaluation of transgene expression at the level of transcription and translation.

Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2009-2013

10. Ministry of Science and Higher Education N N402 471437

“Comparison of genetic basis of abdominal aortic aneurysm and aortoiliac occlusive disease based on the association analysis of gene polymorphisms of selected metalloproteinases and their inhibitors”

Project leader :  prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2009-2012

11. ERIN no.: 227750

“Support study for the identification of potential needs and possibilities for an integrated European infrastructure network of animal facilities in ruminant physiology and breeding”

Project leader:  prof. dr hab. Z. Smorąg, cooperation:  prof. R. Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 18 months,  2008-2010

12. Ministry of Science and Higher Education N N403 209635

“Association analysis of selected gene polymorphisms and abdominal aortic aneurysm oraortoiliac occlusive disease”

Project leader: dr hab. Marcin Gabriel, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2008-2010

13. Ministry of Science and Higher Education N N402 209835

“Genetic factors involved in the reaction to thiopurine drugs in patients with inflammatory bowel disease”

Project leader:  prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2008-2012

14. Ministry of Science and Higher Education N N401 014435

„Genetic basis of selected hamartoma polyposis syndroms”

Supervisor of the project : prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project:  2008-2010

15. Ministry of Science and Higher Education N N402 287436

“Association analysis of polymorphisms of selected genes with the risk of differentiated thyroid cancer, clinical course and response to treatment ”

Supervisor of the project:  mgr Marta Kaczmarek, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project:  2009-2011

Collaborations

Poznań University of Life Sciences, Department of Biochemistry and Biotechnology, Poland.

National Research Institute of Animal Production in Balice, Poland.

Poznań University of Medical Sciences, Poland.

Foundation of Cardiac Surgery Development, Poland.

Burns Treatment Centre in Siemianowice Śląskie, Poland.

Laboratory of Molecular Genetics in Poznań, Poland.

Institute of Natural Fibres and Medicinal Plants, Poland.

PozLab sp. z o.o. (Ltd), Poland.

Adam Mickiewicz University in Poznań, NanoBioMedical Centre, Poland.

Regional Hospital in Poznan, Poland.

Awards

Awarded: dr n. med. Marta Podralska
Dinstinction
Given by: The Organizing Committee of the XXIVth Gliwice Scientific Meetings 2020

Distinction in the contest for the best poster presentation in Gliwice Scientific Meeting 2020: Identification of irradiation-induced ATM-dependent IncRNAs

Awarded: mgr Erkut Ilaslan
Scholarship
Given by: Director IBCH PAS

Scholarship 2020/21

Awarded: dr n. med. Maciej Śmiałek
The Professor W. Bielański award
Given by: Society of Reproductive Biology

For two related original articles published in 2020.

Awarded:
dr n. roln. Oliwia Zakerska-Banaszak
dr hab. n. med. Marzena Skrzypczak-Zielińska
prof. dr hab. n. med. Ryszard Słomski
Biocodex award
Given by: Biocodex

Award in the competition 'Microbiota in health and disease' for funding a research project entitled "Treatment of patients with irritable bowel syndrome (IBS) by means of intestinal microbiota transplantation - evaluation of the therapy and its effect on the change of the intestinal microbiome". Manager dr Marcin Gabryel.

Awarded:
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
dr hab. n. med. Kamila Kusz-Zamelczyk
prof. dr hab. n. biol. Jadwiga Jaruzelska
mgr inż. Damian Janecki
Publication of the year 2019
Given by: Director of the Institute of Human Genetics PAS

Award of the Director of the Institute of Human Genetics of the Polish Academy of Sciences for a review entitled „PUM1 and PUM2 exhibit different modes of regulation for SIAH1 That Involve cooperativity with Nanos paralogues" published in the journal Cellular and Molecular Life Sciences, which awarded the title PUBLICATION OF THE YEAR 2019.

Awarded:
prof. dr hab. n. med. Ryszard Słomski
dr n. roln. Szymon Hryhorowicz
dr n. med. Marta Kaczmarek-Ryś
dr n. przyr. Aleksandra Korcz
Publication of the year 2019
Given by: Director of the Institute of Human Genetics PAS

Award of the Director of the Institute of Human Genetics of the Polish Academy of Sciences for a review entitled "Allosteric Modulation of Cannabinoid Receptor 1 — Current Challenges and Future Opportunities” published in the International Journal of Molecular Sciences, which was awarded the title of PUBLICATION OF THE YEAR 2019.

Awarded: dr n. med. Marcin Sajek
Postdoctoral fellowship within Bekker Programme of the Polish National Agency for Academic Exchange.
Given by: The Polish National Agency for Academic Exchange

Postdoctoral fellowship within Bekker Programme of the Polish National Agency for Academic Exchange. The research stay will be carried out at the University of Colorado, Denver, USA.

Awarded: prof. dr hab. n. med. Ryszard Słomski
Statuette of Honorary Hipolit and the title of “Leader of Organic Work”.
Given by: President of the Hipolit Cegielski Society

Poznań, October 9th, 2019.

President of the Hipolit Cegielski Society, Dr. Marian Król, handed out to Professor Ryszard Słomski, a letter informing about the awarding of the Statuette of Honorary Hipolit and the title of “Leader of Organic Work”. The Chapter's decision is an expression of the highest recognition for scientific, teaching as well as charitable and socio-cultural activity in promoting the idea of organic work.

Awarded: dr hab. n. med. Ewa Strauss
Award
Given by: Polskie Society of Vascular Surgery

Award for the best presentation in the Fast Track Session, entitled “Relationship between polymorphisms of selenoprotein genes SELENOS, GPX4 and SEPP1, peripheral artery disease and the interindividual variability of the ankle-brachial index”.

Awarded: dr hab. n. med. Kamila Kusz-Zamelczyk
Nomination for the Polish Inteligent Development Award 2019
Given by: Centrum for Intelligent Development

Dr hab. Kamila Kusz-Zamelczyk has been nominated for the Polish Intelligent Development Award 2019 in the category: Scientist of the future for the project: " Badania potencjalnej roli białek NANOS w kontroli translacji funkcjonalnie powiązanych ze sobą mRNA, w ludzkich komórkach linii płciowej: poszukiwanie mechanizmu potranskrypcyjnych regulonów u ssaków." The winners of this prestigious award have been for four years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.