The Department of Nucleic Acid Function conducts research related to the genetics of the molecular diagnostics of familial colorectal polyposis (FAP) and medullary thyroid cancer. Our research also focuses on the genes involved in osteoporosis, Crohn's disease, Alzheimer's disease, frontotemporal dementia, aortic aneurysm and spermatogenesis. The department has also been working in the field of biotechnology on transgenic animals for biomedical applications.
Department of Nucleic Acid Function
Featured publications
No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise.
Światowy WJ, Zieliński J, Osielska MA, Kusy K, Wieliński D, Pławski A, Jagodziński PP
J Appl Genet, 2023 Feb;64(1):81-87. doi: 10.1007/s13353-022-00736-6. Epub 2022 Nov 10. PMID: 36352208IF-2.653 MNiSW-140
In silico and in vitro analysis of the impact of single substitutions within EXO motifs on Hsa MiR 1246 intercellular transfer in breast cancer cell.
Rybarczyk A, Lehmann T, Iwańczyk-Skalska E, Juzwa W, Pławski A, Kopciuch K, Blazewicz J, Jagodziński PP
J Appl Gene,t 2023 Feb;64(1):105-124. doi: 10.1007/s13353-022-00730-y. Epub 2022 Nov 17IF-2.653 MNiSW-140
Methodological Changes in the Field of Paleogenetics.
Danielewski M, Zuraszek J, Zielińska A, Herzig K, Słomski R, Walkowiak J, Wielgus K
Genes 2023, 14, 234. https://doi.org/10.3390/genes14010234IF-4.141 MNiSW-100
Development of a Protein-Rich By-Product by 23 Factorial Design: Characterization of Its Nutritional Value and Sensory Analysis.
Dos Santos TR, Dos Santos Melo J, Dos Santos AV, Severino P, Lima ÁS, Souto EB, Zielińska A, Cardoso JC
Molecules 2022, 27(24), 8918; https://doi.org/10.3390/molecules27248918IF-4,927 MNiSW-140
Endoscopic surveillance and treatment of upper GI tract lesions in patients with familial adenomatous polyposis--A new perspective on an old disease.
Paszkowski J, Samboski P, Kucharski M, Cwaliński J, Banasiewicz T, Pławski A
Genes (MDPI), 2022, 13 (12), 2329, 11 stron, doi: 10.3390/genes13122329IF-4,141 MNiSW-100
Strong Hereditary Predispositions to Colorectal Cancer
Hryhorowicz Sz, Kaczmarek-Ryś M, Lis-Tanaś E, Porow J, Szuman M, Grot N, Kryszczyńska A, Paszkowski J, Banasiewicz T and Pławski A
Genes (MDPI), 2022, 13 (12), Number: 2326, 10.3390/genes13122326IF-4,141 MNiSW-100
Pleiotropic Effects of Vitamin D in Patients with Inflammatory Bowel Diseases.
Szymczak-Tomczak A, Ratajczak AE, Kaczmarek-Ryś M, Hryhorowicz S, Rychter AM, Zawada A; Słomski R, Dobrowolska A, Krela-Kaźmierczak I
J Clin Med (MDPI). 2022 Sept 27, 11 (19): 5715,23 str, https://doi.org/10.3390/jcm11195715IF-4,694 MNiSW-140
C10orf55, CASC2, and SFTA1 lncRNAs Are Potential Biomarkers to Assess Radiation Therapy Response in Head and Neck Cancers
Paszkowska A, Kolenda T, Guglas K, Kozłowska-Masłoń J, Podralska M, Teresiak A, Bliźniak R, Dzikiewicz-Krawczyk A, Lamperska K
J Person Med (MDPI), .2022 Oct, 12 (10): 1696, 18 str,IF-3,508 MNiSW-70
Radio-lncRNAs: Biological Function and Potential Use as Biomarkers for Personalized Oncology
Kozłowska-Masłoń J, Guglas K, Paszkowska A, Kolenda T, Podralska M, Teresiak A, Bliźniak R, Lamperska K,
J Person Med (MDPI), 2022 Oct, 12 (10): 1605. 23 strony, https://doi.org/10.3390/jpm12101605IF-3,508 MNiSW-70
Lipid-Based Nanoparticulate Systems for the Ocular Delivery of Bioactives with Anti-Inflammatory Properties
Ana R.d, Fonseca J, Karczewski J, Silva, A.M, Zielińska A, Souto E.B.
Int J Mol Sci. (MDPI), 2022, 23 (20): 12102, 15 str., https://doi.org/10.3390/ijms232012102IF-6,208 MNiSW-140
All publications
Featured research projects
1. Acronym MEDPIG, INNOMED/I/17/NCBR/2014
“Development of an innovative technology for using transgenic pig tissues for biomedical purposes”
Task no 5. Development and characterization of new gene construct for transgenesis.
Obtained financial support from the National Centre for Research and Development from the funds of the Operational Programme Innovative Economy within the framework of the European Regional Development Fund.
Agreement no INNOMED 1/20106/07/2013/6
Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2014-2017
2. Acronym ONKOKAN, INNOMED/I/11/NCBR/2014
“Development of technology for obtaining cannabinoids from hemp with low THC content as agents supporting treatment for cancer patients”
Task no 7. Assessment of genetic polymorphisms and genes expression involved in the metabolism of cannabinoids and response to their application in the Polish population
Agreement no INNOMED 1/20104/07/2013/7
Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2014-2017
3. “Sharing Advances on Large Animal Models (SALAAM)”
COST Action BM1308. Management Committee Member.
Coordinator Prof. Eckhard Wolf (Germany)
http://www.salaam.genzentrum.lmu.de
http://www.cost.eu/COST_Actions/bmbs/Actions/BM1308
MC member – prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Duration of the project: 19.05.2014-18.05.2018
4. UDA/POIG.01.04.00-24-002/11-00
Operational Programme Innovative Economy 2007-2013 under Measure 1.4 Support for special projects of priority axis 1 Research and development of new technologies. „Development studies on efficient technology of production fluid into renal transplantation,
Project leader: Prof. dr hab. n. med. Florian Ryszka, Pharmaceutical Research and Production Plant „BIOCHEFA”
Research task „Development of the methodology to determine the zygosity of pigs for xenotransplantation of kidney and reproducible animal model”
Task leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2012-2013
5. Ministry of Science and Higher Education N N303 457238
“Investigation of the degree of genetic determination in prenatal testing – analysis of genetic variability in twins”
Project leader : prof. dr hab. Krystyna Cieślik, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2010-2014
6. Ministry of Science and Higher Education N N401 037838
“Analysis of gene polymorphisms influenced on reaction to anaesthetics in patients under general anaesthesia and on reaction to analgetics in the postoperative period”
Project leader : dr Adam Mikstacki, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2010-2014
7. Development project N R13 0018 06
„Inhibition of the activation of the coagulation system and systemic inflammatory response during extracorporeal respiratory support in an animal model”
Project leader : dr Wiesław Zygmunt Królikowski, CM UJ
Task: Analysis of genetic variability of pigs for somatic cloning and xenotransplantation .
Task leader: prof. dr hab. Z. Smorąg, współpraca prof. R. Słomski
Duration of the project: 2009-2012
8. Development project N R13 0075 06/2009
„Transgenic bioprosthetic heart valves based on the tissue engineering techniques”
Project leader: dr hab. Romuald Antoni Cichoń, Foundation of Cardiac Surgery Development in Zabrze
Task: Molecular and cytogenetic characterization of potentially transgenic pigs
Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2012
9. Development project N R12 0036 06/2009
„Obtaining transgenic pigs as donors of tissues and organs for transplantation in humans and their biotechnological, medical and physiological characteristics”
Project leader : prof. dr hab. Z. Smorąg, IZ-PIB
Task no 5. Molecular and cytogenetic characteristics of the transgenic pigs and evaluation of transgene expression at the level of transcription and translation.
Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2013
10. Ministry of Science and Higher Education N N402 471437
“Comparison of genetic basis of abdominal aortic aneurysm and aortoiliac occlusive disease based on the association analysis of gene polymorphisms of selected metalloproteinases and their inhibitors”
Project leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2012
11. ERIN no.: 227750
“Support study for the identification of potential needs and possibilities for an integrated European infrastructure network of animal facilities in ruminant physiology and breeding”
Project leader: prof. dr hab. Z. Smorąg, cooperation: prof. R. Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 18 months, 2008-2010
12. Ministry of Science and Higher Education N N403 209635
“Association analysis of selected gene polymorphisms and abdominal aortic aneurysm oraortoiliac occlusive disease”
Project leader: dr hab. Marcin Gabriel, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2010
13. Ministry of Science and Higher Education N N402 209835
“Genetic factors involved in the reaction to thiopurine drugs in patients with inflammatory bowel disease”
Project leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2012
14. Ministry of Science and Higher Education N N401 014435
„Genetic basis of selected hamartoma polyposis syndroms”
Supervisor of the project : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2010
15. Ministry of Science and Higher Education N N402 287436
“Association analysis of polymorphisms of selected genes with the risk of differentiated thyroid cancer, clinical course and response to treatment ”
Supervisor of the project: mgr Marta Kaczmarek, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2011
Collaborations
Poznań University of Life Sciences, Department of Biochemistry and Biotechnology, Poland.
National Research Institute of Animal Production in Balice, Poland.
Poznań University of Medical Sciences, Poland.
Foundation of Cardiac Surgery Development, Poland.
Burns Treatment Centre in Siemianowice Śląskie, Poland.
Laboratory of Molecular Genetics in Poznań, Poland.
Institute of Natural Fibres and Medicinal Plants, Poland.
PozLab sp. z o.o. (Ltd), Poland.
Adam Mickiewicz University in Poznań, NanoBioMedical Centre, Poland.
Awards
Awarded:
prof. dr hab. n. med. Ryszard Słomski
The Golden Hundred of Polish Agriculture. Gala "Wprost" 2022.
Given by: Awarding the "Wprost" Eagle for innovations in the field of hemp cultivation and the development of non-fibrous hemp.
In the category of Innovations in the agricultural and food industry, the Institute of Natural Fibres and Medicinal Plants National Research Institute was awarded, which is the only research centre in Poland with almost 90 years of experience in work on hemp. Director of the Institute Dr. Eng. n. med. Rafał Spachacz said that we are happy that we can work together to implement a non-fiber hemp cultivation program and this award is a mobilization for us to further action. Together with the director, the award was received by prof. dr hab. Ryszard Słomski, MD, Katarzyna Wielgus, Paweł Gała, PhD, and Karolina Wielgus, PhD. Institute of Human Genetics PAS represented by prof. Słomski previously implemented the Innomed project. Development of a technology for obtaining cannabinoids from hemp with a low THC content as means supporting the treatment of oncological patients. Acronym: ONKOKAN.
Awarded:
dr n. chem. Aleksandra Zielińska
The First Prize in the competition for the best papers “Molecules 2020 Best Paper Award for Anniversary Special Issues”, published in the “Anniversary Special Issues”.
Given by: MDPI Molecules
The award was granted for the publication of:
„Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology”
Aleksandra Zielińska, Filipa Carreiró, Ana M. Oliveira, Andreia Neves, Bárbara Pires, D. Nagasamy Venkatesh, Alessandra Durazzo, Massimo Lucarini, Piotr Eder, Amélia M. Silva, Antonello Santini and Eliana B. Souto. Molecules 2020, 25(16), 3731; DOI: 10.3390/molecules25163731
Molecules (ISSN 1420-3049) IF 4.927; Min 140.
Awarded:
dr n. med. Maciej Śmiałek
Nagroda im. Prof. W. Bielańskiego przyznana przez Towarzystwo Biologii Rozrodu za dwa powiązane ze sobą artykuły oryginalne opublikowane w 2020 roku.
Given by: Towarzystwo Biologii Rozrodu
za dwa powiązane ze sobą artykuły oryginalne opublikowane w 2020 roku.
Awarded:
prof. dr hab. n. med. Krzysztof Szyfter
Head of Local Self-Parliament
Given by: Local Self-parliament
Prof. Krzysztof Szyfter was awarded by Marek Woźniak, the Head of Local Self-parliament for his merits to Great-Poland District.
Awarded:
prof. dr hab. n. biol. Jadwiga Jaruzelska
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
prof. dr hab. n. biol. Jadwiga Jaruzelska
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
Award of the Faculty of Medical Sciences of the Polish Academy of Sciences
Given by: Faculty of Medical Sciences of the PAS
Prof. Jadwiga Jaruzelska, dr Marcin Piotr Sajek, dr Maciej Jerzy Śmiałek and Ms Erkut Ilaslan were awarded by Medical Division of the Polish Academy of Sciences for 5 articles entitled: “Role of NANOS and PUM proteins in human reproduction and infertility”.
Awarded:
dr n. med. Maciej Śmiałek
Prize of the Prime Minister of the Republic of Poland
Given by: Prize of the Prime Minister of the Republic of Poland
Dr Maciej Jerzy Śmiałek was awarded a Prize of the Prime Minister of the Republic of Poland for his PhD dissertation „A global identification of mRNAs regulated by PUM1 and PUM2 and their protein cofactors, in the model of human seminoma (TCam-2)”defended in 2020.
Awarded:
dr n. chem. Aleksandra Zielińska
FNP START 2021 Program.
Given by: FNP
Dr Aleksandra Zielińska from the Department of Nucleic Acids Function of our Institute has become a laureate of the FNP START 2021 Program.
Awarded:
prof. dr hab. n. med. Ryszard Słomski
Officer's Cross of the Order of Polonia Restituta.
Given by: President of the Republic of Poland
Prof. dr hab. n. med. Ryszard Słomski was decorated with the Officer's Cross of the Order of Polonia Restituta. The ceremony took place on June 7, 2021 at the Wielkopolska Voivodship Office in Poznań. The Cross was awarded by the President of the Republic of Poland, Andrzej Duda, on the Professor's 70th birthday. Due to the pandemic, the handing over was delayed by a year and a half. The Order was awarded for the Professor's scientific and research activities, including pioneering DNA studies in the country for diagnostic, medical and forensic purposes, as well as the implementation and dissemination of molecular diagnostics (DNA fingerprinting 1987; PCR polymerase chain reaction 1989). Works in the field of medical biotechnology constitute an important field of interest and include obtaining of transgenic animals as bioreactors for the production of peptides and tissues for xenotransplantation. Biological dressings made of the skin of transgenic pigs have been used many times in the Burn Treatment Center in Siemianowice Śląskie.
Awarded:
dr hab. n. med. Anna Kowalska
Dr hab. Anna Kowalska received the scientific team award of the Rector of Poznan Karol Marcinkowski University of Medical Sciences awarded to a team consisting of: Dr hab. Zuzanna Ślebioda, Prof. dr hab. Barbara Dorocka-Bobkowska, Dr hab. Anna Kowalska.
Dr hab. Anna Kowalska received the scientific team award of the Rector of Poznan Karol Marcinkowski University of Medical Sciences awarded to a team consisting of: Dr hab. Zuzanna Ślebioda, Prof. dr hab. Barbara Dorocka-Bobkowska, Dr hab. Anna Kowalska.
Given by: Rector of Poznan Karol Marcinkowski University of Medical Sciences
for a series of 7 papers on selected genetic aspects and systemic conditions accompanying chronic recurrent aphthous stomatitis
Awarded:
dr n. med. Marta Podralska
Dinstinction
Given by: The Organizing Committee of the XXIVth Gliwice Scientific Meetings 2020
Distinction in the contest for the best poster presentation in Gliwice Scientific Meeting 2020: Identification of irradiation-induced ATM-dependent IncRNAs