The Department of Nucleic Acid Function conducts research related to the genetics of the molecular diagnostics of familial colorectal polyposis (FAP) and medullary thyroid cancer. Our research also focuses on the genes involved in osteoporosis, Crohn's disease, Alzheimer's disease, frontotemporal dementia, aortic aneurysm and spermatogenesis. The department has also been working in the field of biotechnology on transgenic animals for biomedical applications.
Department of Nucleic Acid Function
Featured publications
Nanopesticides in Agriculture: Benefits and Challenge in Agricultural Productivity, Toxicological Risks to Human Health and Environment.
Chaud M, Souto EP, Zielinska A, Severino P, Batain F, Oliveira-Junior J and Alves T
Toxics (MDPI), 2021 June, 9 (6) , e131, 19 stron. https://doi.org/10.3390/toxics9060131IF-3,271 MNiSW-70
In vitro methodologies for toxicological assessment of drug delivery nanocarriers.
Teixeira MC, Rodriques CG, Zielińska A, Campos JR, Fernandes AR, Shimojo AAM, Souto EB
W: “Nanotoxicology and Nanoecotoxicology”, Vol. 1, Editors: V. Kumar, P. Guleria, S. Ranjan, N. Dasgupta, E. Lichtfouse, Springer, ISBN: 978-3-030-63241-0, 2021.MNiSW-20
Quality by Design Approach for the Development of Liposome Carrying Ghrelin for Intranasal Administration.
de Barros C, Aranha N, Severino P, Souto EB, Zielińska A, Lopes A, Rios A, Batain F, Crescencio K , Chaud M and Alves T
Pharmaceutics, 2021, 13, e686, 23 str, doi.10.3390/pharmaceutics13050686IF-4,286 MNiSW-100
Molecular Mechanisms Associated with ROS-Dependent Angiogenesis in Lower Extremity Artery Disease.
Hutchings G, Kruszyna Ł , Nawrocki MJ , Strauss E, Bryl R, Spaczyńska J, Perek B, Jemielity M, Mozdziak P, Kempisty B, Nowicki M, Krasiński Z
Antioxidants, 2021, 10, e735, 22 str.,.doi:10.3390/antiox10050735IF-5,014 MNiSW-100
CD36 polymorphisms and the age of disease onset in patients with pathogenic variants within the mutation cluster region of APC.
Connor T, McPhillips M, Hipwell M, Ziolkowski A, Oldmeadow C, Clapham M, Pockney PG, Lis E, Banasiewicz T, Pławski A, Scott RJ
Hered Cancer Clin Pract, 2021, 19, art. 25, 9 str, https://doi.org/10.1186/s13053-021-00183-0IF-2,237 MNiSW-70
Silver nanoparticles obtained from Brazilian pepper extracts with synergistic anti-microbial effect: production, characterization, hydrogel formulation, cell viability and in vitro efficacy.
de Oliveira DM ,Menezes DB, Andrade LR, da C. Lima F, Hollanda L, Zielińska A, Sanchez-Lopez E, Souto EB,, Severino P
Pharm Dev Technol, 2021, 26 (5): 539-548, Epub Mar 9; doi: 10.1080/10837450.2021.1898634IF-2,169 MNiSW-40
Cannabidiol in Neurological and Neoplastic Diseases: Latest Developments on the Molecular Mechanism of Action.
Ożarowski M, Karpiński TM, Zielińska A, Souto EB, Wielgus K
Int J Mol Sci, 2021, 22, e4294.18 str., https:// doi.org/10.3390/ijms22094294IF-4,556 MNiSW-140
Vitamin D, Vitamin D Receptor (VDR) Gene Polymorphisms (ApaI and FokI), and Bone Mineral Density in Patients With Inflammatory Bowel Disease.
Szymczak-Tomczak A, Kaczmarek-Ryś M, Hryhorowicz S, Michalak M, Eder P, Skrzypczak-Zielińska M, Łykowska-Szuber L, Tomczak M, Słomski R, Dobrowolska A, Krela-Kaźmierczak I
J Clin Densitometry, 2021 April–June 24 (2): 233-242, Epub 2020 Oct 24, doi: 10.1016/j.jocd.2020.10.009IF-2,310 MNiSW-100
Cancer Nanopharmaceuticals: Physicochemical Characterization and In Vitro/In Vivo Applications.
Zielińska A, Szalata M, Gorczyński A , Karczewski J, Eder P, Severino P, Cabeda JM, Eliana B. Souto EB and Słomski R
Cancers, 2021, 13 (8), e1896. doi:10.3390/cancers13081896, 38 str.IF-6,126 MNiSW-140
Juvenile polyposis syndrome and hereditary haemorrhagic telangiectasia caused by the SMAD4 gene mutation in a paediatric patient – a case report and a review of the literature. Case report.
Kaps-Kopiec D, Pławski A, Badura-Stronka M, Teisseyre M, Dąbalski M, Cielecka-Kuszyk J, Pawłowska J
MNiSW-20
All publications
Featured research projects
1. Acronym MEDPIG, INNOMED/I/17/NCBR/2014
“Development of an innovative technology for using transgenic pig tissues for biomedical purposes”
Task no 5. Development and characterization of new gene construct for transgenesis.
Obtained financial support from the National Centre for Research and Development from the funds of the Operational Programme Innovative Economy within the framework of the European Regional Development Fund.
Agreement no INNOMED 1/20106/07/2013/6
Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2014-2017
2. Acronym ONKOKAN, INNOMED/I/11/NCBR/2014
“Development of technology for obtaining cannabinoids from hemp with low THC content as agents supporting treatment for cancer patients”
Task no 7. Assessment of genetic polymorphisms and genes expression involved in the metabolism of cannabinoids and response to their application in the Polish population
Agreement no INNOMED 1/20104/07/2013/7
Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2014-2017
3. “Sharing Advances on Large Animal Models (SALAAM)”
COST Action BM1308. Management Committee Member.
Coordinator Prof. Eckhard Wolf (Germany)
http://www.salaam.genzentrum.lmu.de
http://www.cost.eu/COST_Actions/bmbs/Actions/BM1308
MC member – prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Duration of the project: 19.05.2014-18.05.2018
4. UDA/POIG.01.04.00-24-002/11-00
Operational Programme Innovative Economy 2007-2013 under Measure 1.4 Support for special projects of priority axis 1 Research and development of new technologies. „Development studies on efficient technology of production fluid into renal transplantation,
Project leader: Prof. dr hab. n. med. Florian Ryszka, Pharmaceutical Research and Production Plant „BIOCHEFA”
Research task „Development of the methodology to determine the zygosity of pigs for xenotransplantation of kidney and reproducible animal model”
Task leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2012-2013
5. Ministry of Science and Higher Education N N303 457238
“Investigation of the degree of genetic determination in prenatal testing – analysis of genetic variability in twins”
Project leader : prof. dr hab. Krystyna Cieślik, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2010-2014
6. Ministry of Science and Higher Education N N401 037838
“Analysis of gene polymorphisms influenced on reaction to anaesthetics in patients under general anaesthesia and on reaction to analgetics in the postoperative period”
Project leader : dr Adam Mikstacki, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2010-2014
7. Development project N R13 0018 06
„Inhibition of the activation of the coagulation system and systemic inflammatory response during extracorporeal respiratory support in an animal model”
Project leader : dr Wiesław Zygmunt Królikowski, CM UJ
Task: Analysis of genetic variability of pigs for somatic cloning and xenotransplantation .
Task leader: prof. dr hab. Z. Smorąg, współpraca prof. R. Słomski
Duration of the project: 2009-2012
8. Development project N R13 0075 06/2009
„Transgenic bioprosthetic heart valves based on the tissue engineering techniques”
Project leader: dr hab. Romuald Antoni Cichoń, Foundation of Cardiac Surgery Development in Zabrze
Task: Molecular and cytogenetic characterization of potentially transgenic pigs
Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2012
9. Development project N R12 0036 06/2009
„Obtaining transgenic pigs as donors of tissues and organs for transplantation in humans and their biotechnological, medical and physiological characteristics”
Project leader : prof. dr hab. Z. Smorąg, IZ-PIB
Task no 5. Molecular and cytogenetic characteristics of the transgenic pigs and evaluation of transgene expression at the level of transcription and translation.
Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2013
10. Ministry of Science and Higher Education N N402 471437
“Comparison of genetic basis of abdominal aortic aneurysm and aortoiliac occlusive disease based on the association analysis of gene polymorphisms of selected metalloproteinases and their inhibitors”
Project leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2012
11. ERIN no.: 227750
“Support study for the identification of potential needs and possibilities for an integrated European infrastructure network of animal facilities in ruminant physiology and breeding”
Project leader: prof. dr hab. Z. Smorąg, cooperation: prof. R. Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 18 months, 2008-2010
12. Ministry of Science and Higher Education N N403 209635
“Association analysis of selected gene polymorphisms and abdominal aortic aneurysm oraortoiliac occlusive disease”
Project leader: dr hab. Marcin Gabriel, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2010
13. Ministry of Science and Higher Education N N402 209835
“Genetic factors involved in the reaction to thiopurine drugs in patients with inflammatory bowel disease”
Project leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2012
14. Ministry of Science and Higher Education N N401 014435
„Genetic basis of selected hamartoma polyposis syndroms”
Supervisor of the project : prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2008-2010
15. Ministry of Science and Higher Education N N402 287436
“Association analysis of polymorphisms of selected genes with the risk of differentiated thyroid cancer, clinical course and response to treatment ”
Supervisor of the project: mgr Marta Kaczmarek, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2009-2011
Collaborations
Poznań University of Life Sciences, Department of Biochemistry and Biotechnology, Poland.
National Research Institute of Animal Production in Balice, Poland.
Poznań University of Medical Sciences, Poland.
Foundation of Cardiac Surgery Development, Poland.
Burns Treatment Centre in Siemianowice Śląskie, Poland.
Laboratory of Molecular Genetics in Poznań, Poland.
Institute of Natural Fibres and Medicinal Plants, Poland.
PozLab sp. z o.o. (Ltd), Poland.
Adam Mickiewicz University in Poznań, NanoBioMedical Centre, Poland.
Awards
Awarded:
dr n. chem. Aleksandra Zielińska
Dr Aleksandra Zielińska z Zakładu Funkcji Kwasów Nukleinowych naszego instytutu została laureatką Programu START 2021.
Given by: FNP
Stypendium Programu START 2021
Awarded:
prof. dr hab. n. med. Ryszard Słomski
Krzyżem Oficerskim Orderu Odrodzenia Polski
Krzyżem Oficerskim Orderu Odrodzenia Polski
Given by: Prezydent RP
Order został przyznany za działalność naukowo-badawczą Profesora obejmującą pionierskie badania DNA w kraju dla potrzeb diagnostycznych, medyczno-sądowych oraz wdrożenie i upowszechnienie diagnostyki molekularnej (odcisk genetyczny 1987; łańcuchowa reakcja polimerazy PCR 1989). Prace z zakresu biotechnologii medycznej stanowią ważny nurt zainteresowań i obejmują uzyskiwanie transgenicznych zwierząt jako bioreaktorów do wytwarzania peptydów oraz tkanek dla potrzeb ksenotransplantacji. Opatrunki biologiczne ze skóry transgenicznych świń zostały wielokrotnie zastosowane w Centrum Leczenia Oparzeń w Siemianowicach Śląskich.
Awarded:
dr hab. n. med. Anna Kowalska
Dr hab. Anna Kowalska received the scientific team award of the Rector of Poznan Karol Marcinkowski University of Medical Sciences awarded to a team consisting of: Dr hab. Zuzanna Ślebioda, Prof. dr hab. Barbara Dorocka-Bobkowska, Dr hab. Anna Kowalska.
Dr hab. Anna Kowalska received the scientific team award of the Rector of Poznan Karol Marcinkowski University of Medical Sciences awarded to a team consisting of: Dr hab. Zuzanna Ślebioda, Prof. dr hab. Barbara Dorocka-Bobkowska, Dr hab. Anna Kowalska.
Given by: Rector of Poznan Karol Marcinkowski University of Medical Sciences
for a series of 7 papers on selected genetic aspects and systemic conditions accompanying chronic recurrent aphthous stomatitis
Awarded:
dr n. med. Marta Podralska
Dinstinction
Given by: The Organizing Committee of the XXIVth Gliwice Scientific Meetings 2020
Distinction in the contest for the best poster presentation in Gliwice Scientific Meeting 2020: Identification of irradiation-induced ATM-dependent IncRNAs
Awarded:
mgr Erkut Ilaslan
Scholarship
Given by: Director IBCH PAS
Scholarship 2020/21
Awarded:
dr n. med. Maciej Śmiałek
The Professor W. Bielański award
Given by: Society of Reproductive Biology
For two related original articles published in 2020.
Awarded:
dr n. roln. Oliwia Zakerska-Banaszak
dr hab. n. med. Marzena Skrzypczak-Zielińska
prof. dr hab. n. med. Ryszard Słomski
dr n. roln. Oliwia Zakerska-Banaszak
dr hab. n. med. Marzena Skrzypczak-Zielińska
prof. dr hab. n. med. Ryszard Słomski
Biocodex award
Given by: Biocodex
Award in the competition 'Microbiota in health and disease' for funding a research project entitled "Treatment of patients with irritable bowel syndrome (IBS) by means of intestinal microbiota transplantation - evaluation of the therapy and its effect on the change of the intestinal microbiome". Manager dr Marcin Gabryel.
Awarded:
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
dr hab. n. med. Kamila Kusz-Zamelczyk
prof. dr hab. n. biol. Jadwiga Jaruzelska
mgr inż. Damian Janecki
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
dr hab. n. med. Kamila Kusz-Zamelczyk
prof. dr hab. n. biol. Jadwiga Jaruzelska
mgr inż. Damian Janecki
Publication of the year 2019
Given by: Director of the Institute of Human Genetics PAS
Award of the Director of the Institute of Human Genetics of the Polish Academy of Sciences for a review entitled „PUM1 and PUM2 exhibit different modes of regulation for SIAH1 That Involve cooperativity with Nanos paralogues" published in the journal Cellular and Molecular Life Sciences, which awarded the title PUBLICATION OF THE YEAR 2019.
Awarded:
prof. dr hab. n. med. Ryszard Słomski
dr n. roln. Szymon Hryhorowicz
dr n. med. Marta Kaczmarek-Ryś
dr n. przyr. Aleksandra Korcz
prof. dr hab. n. med. Ryszard Słomski
dr n. roln. Szymon Hryhorowicz
dr n. med. Marta Kaczmarek-Ryś
dr n. przyr. Aleksandra Korcz
Publication of the year 2019
Given by: Director of the Institute of Human Genetics PAS
Award of the Director of the Institute of Human Genetics of the Polish Academy of Sciences for a review entitled "Allosteric Modulation of Cannabinoid Receptor 1 — Current Challenges and Future Opportunities” published in the International Journal of Molecular Sciences, which was awarded the title of PUBLICATION OF THE YEAR 2019.
Awarded:
dr n. med. Marcin Sajek
Postdoctoral fellowship within Bekker Programme of the Polish National Agency for Academic Exchange.
Given by: The Polish National Agency for Academic Exchange
Postdoctoral fellowship within Bekker Programme of the Polish National Agency for Academic Exchange. The research stay will be carried out at the University of Colorado, Denver, USA.