The Department of Nucleic Acid Function conducts research related to the genetics of the molecular diagnostics of familial colorectal polyposis (FAP) and medullary thyroid cancer. Our research also focuses on the genes involved in osteoporosis, Crohn's disease, Alzheimer's disease, frontotemporal dementia, aortic aneurysm and spermatogenesis. The department has also been working in the field of biotechnology on transgenic animals for biomedical applications.

Keywords:

Featured publications

Featured research projects

1. Acronym MEDPIG, INNOMED/I/17/NCBR/2014

“Development of an innovative technology for using transgenic pig tissues for biomedical purposes”

Task no 5. Development and characterization of new gene construct for transgenesis.

Obtained financial support from the National Centre for Research and Development from the funds of the Operational Programme Innovative Economy within the framework of the European Regional Development Fund.

Agreement no INNOMED 1/20106/07/2013/6

Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University

Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2014-2017

2. Acronym ONKOKAN, INNOMED/I/11/NCBR/2014

“Development of technology for obtaining cannabinoids from hemp with low THC content as agents supporting treatment for cancer patients”

Task no 7. Assessment of genetic polymorphisms and genes expression involved in the metabolism of cannabinoids and response to their application in the Polish population

Agreement no INNOMED 1/20104/07/2013/7

Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University

Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2014-2017

4. UDA/POIG.01.04.00-24-002/11-00

Operational Programme Innovative Economy 2007-2013 under Measure 1.4 Support for special projects of priority axis 1 Research and development of new technologies. „Development studies on  efficient technology of production fluid into renal transplantation,

Project leader: Prof. dr hab. n. med. Florian Ryszka, Pharmaceutical Research and Production Plant „BIOCHEFA”

Research task „Development of the methodology to determine the zygosity of pigs for xenotransplantation of kidney and reproducible animal model”

Task leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2012-2013

5. Ministry of Science and Higher Education N N303 457238

“Investigation of the degree of genetic determination in prenatal testing – analysis of genetic variability in twins”

Project leader : prof. dr hab. Krystyna Cieślik, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2010-2014

6. Ministry of Science and Higher Education N N401 037838

“Analysis of gene polymorphisms influenced on reaction to anaesthetics in patients under general anaesthesia and on reaction to analgetics in the postoperative period”

Project leader : dr Adam Mikstacki, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland

Duration of the project: 2010-2014

7. Development project N R13 0018 06

„Inhibition of the activation of the coagulation system and systemic inflammatory response during extracorporeal respiratory support in an animal model”

Project leader :  dr Wiesław Zygmunt Królikowski, CM UJ

Task: Analysis of genetic variability of pigs for somatic cloning and xenotransplantation .

Task leader: prof. dr hab. Z. Smorąg, współpraca prof. R. Słomski

Duration of the project:  2009-2012

8. Development project N R13 0075 06/2009

„Transgenic bioprosthetic heart valves based on the tissue engineering techniques”

Project leader: dr hab. Romuald Antoni Cichoń, Foundation of Cardiac Surgery Development in Zabrze

Task: Molecular and cytogenetic characterization of potentially transgenic pigs

Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project:  2009-2012

9. Development project N R12 0036 06/2009

„Obtaining transgenic pigs as donors of tissues and organs for transplantation in humans and their biotechnological, medical and physiological characteristics”

Project leader : prof. dr hab. Z. Smorąg, IZ-PIB

Task no 5. Molecular and cytogenetic characteristics of the transgenic pigs and evaluation of transgene expression at the level of transcription and translation.

Task leader : prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2009-2013

10. Ministry of Science and Higher Education N N402 471437

“Comparison of genetic basis of abdominal aortic aneurysm and aortoiliac occlusive disease based on the association analysis of gene polymorphisms of selected metalloproteinases and their inhibitors”

Project leader :  prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2009-2012

11. ERIN no.: 227750

“Support study for the identification of potential needs and possibilities for an integrated European infrastructure network of animal facilities in ruminant physiology and breeding”

Project leader:  prof. dr hab. Z. Smorąg, cooperation:  prof. R. Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 18 months,  2008-2010

12. Ministry of Science and Higher Education N N403 209635

“Association analysis of selected gene polymorphisms and abdominal aortic aneurysm oraortoiliac occlusive disease”

Project leader: dr hab. Marcin Gabriel, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2008-2010

13. Ministry of Science and Higher Education N N402 209835

“Genetic factors involved in the reaction to thiopurine drugs in patients with inflammatory bowel disease”

Project leader:  prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project: 2008-2012

14. Ministry of Science and Higher Education N N401 014435

„Genetic basis of selected hamartoma polyposis syndroms”

Supervisor of the project : prof. dr hab. Ryszard Słomski, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project:  2008-2010

15. Ministry of Science and Higher Education N N402 287436

“Association analysis of polymorphisms of selected genes with the risk of differentiated thyroid cancer, clinical course and response to treatment ”

Supervisor of the project:  mgr Marta Kaczmarek, Institute of Human Genetics,  Polish Academy of Science in Poznan, Poland

Duration of the project:  2009-2011

Collaborations

Awards

Awarded: dr n. chem. Aleksandra Zielińska
FNP START 2021 Program.
Given by: FNP

Dr Aleksandra Zielińska from the Department of Nucleic Acids Function of our Institute has become a laureate of the FNP START 2021 Program.

Awarded: prof. dr hab. n. med. Ryszard Słomski
Officer's Cross of the Order of Polonia Restituta.
Given by: President of the Republic of Poland

Prof. dr hab. n. med. Ryszard Słomski was decorated with the Officer's Cross of the Order of Polonia Restituta. The ceremony took place on June 7, 2021 at the Wielkopolska Voivodship Office in Poznań. The Cross was awarded by the President of the Republic of Poland, Andrzej Duda, on the Professor's 70th birthday. Due to the pandemic, the handing over was delayed by a year and a half. The Order was awarded for the Professor's scientific and research activities, including pioneering DNA studies in the country for diagnostic, medical and forensic purposes, as well as the implementation and dissemination of molecular diagnostics (DNA fingerprinting 1987; PCR polymerase chain reaction 1989). Works in the field of medical biotechnology constitute an important field of interest and include obtaining of transgenic animals as bioreactors for the production of peptides and tissues for xenotransplantation. Biological dressings made of the skin of transgenic pigs have been used many times in the Burn Treatment Center in Siemianowice Śląskie.

Awarded: dr hab. n. med. Anna Kowalska
Dr hab. Anna Kowalska received the scientific team award of the Rector of Poznan Karol Marcinkowski University of Medical Sciences awarded to a team consisting of: Dr hab. Zuzanna Ślebioda, Prof. dr hab. Barbara Dorocka-Bobkowska, Dr hab. Anna Kowalska.

Given by: Rector of Poznan Karol Marcinkowski University of Medical Sciences

for a series of 7 papers on selected genetic aspects and systemic conditions accompanying chronic recurrent aphthous stomatitis

Awarded: dr n. med. Marta Podralska
Dinstinction
Given by: The Organizing Committee of the XXIVth Gliwice Scientific Meetings 2020

Distinction in the contest for the best poster presentation in Gliwice Scientific Meeting 2020: Identification of irradiation-induced ATM-dependent IncRNAs

Awarded: mgr Erkut Ilaslan
Scholarship
Given by: Director IBCH PAS

Scholarship 2020/21

Awarded: dr n. med. Maciej Śmiałek
The Professor W. Bielański award
Given by: Society of Reproductive Biology

For two related original articles published in 2020.

Awarded:
dr n. roln. Oliwia Zakerska-Banaszak
dr hab. n. med. Marzena Skrzypczak-Zielińska
prof. dr hab. n. med. Ryszard Słomski
Biocodex award
Given by: Biocodex

Award in the competition 'Microbiota in health and disease' for funding a research project entitled "Treatment of patients with irritable bowel syndrome (IBS) by means of intestinal microbiota transplantation - evaluation of the therapy and its effect on the change of the intestinal microbiome". Manager dr Marcin Gabryel.

Awarded:
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
dr hab. n. med. Kamila Kusz-Zamelczyk
prof. dr hab. n. biol. Jadwiga Jaruzelska
mgr inż. Damian Janecki
Publication of the year 2019
Given by: Director of the Institute of Human Genetics PAS

Award of the Director of the Institute of Human Genetics of the Polish Academy of Sciences for a review entitled „PUM1 and PUM2 exhibit different modes of regulation for SIAH1 That Involve cooperativity with Nanos paralogues" published in the journal Cellular and Molecular Life Sciences, which awarded the title PUBLICATION OF THE YEAR 2019.

Awarded:
prof. dr hab. n. med. Ryszard Słomski
dr n. roln. Szymon Hryhorowicz
dr n. med. Marta Kaczmarek-Ryś
dr n. przyr. Aleksandra Korcz
Publication of the year 2019
Given by: Director of the Institute of Human Genetics PAS

Award of the Director of the Institute of Human Genetics of the Polish Academy of Sciences for a review entitled "Allosteric Modulation of Cannabinoid Receptor 1 — Current Challenges and Future Opportunities” published in the International Journal of Molecular Sciences, which was awarded the title of PUBLICATION OF THE YEAR 2019.

Awarded: dr n. med. Marcin Sajek
Postdoctoral fellowship within Bekker Programme of the Polish National Agency for Academic Exchange.
Given by: The Polish National Agency for Academic Exchange

Postdoctoral fellowship within Bekker Programme of the Polish National Agency for Academic Exchange. The research stay will be carried out at the University of Colorado, Denver, USA.