The department’s research includes molecular-genetic aspects of cancer, autoimmune and infectious diseases. Mutations and polymorphisms in cancer risk genes are also analysed, as well as genomic rearrangements and chromosomal aberrations in leukaemias, breast, larynx, lung and colon cancers. We also investigate the role of polymorphisms of risk genes in the development of diabetes, multiple sclerosis (MS) and Addison's disease, as well as carrying out a search for genetic markers of hepatitis C virus (HCV) elimination and the effectiveness of therapy for patients with viral hepatitis C.
Department of Molecular Pathology
Featured publications
Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.
Künzel SR, Hoffmann M, Weber S, Künzel K, Kämmerer S, Günscht M, Klapproth E, Rausch JSE, Sadek M, Kolanowski T, Meyer-Roxlau S, Piorkowski C, Tugtekin SM, Rose-John S, Yin X, Mayr M,
Kuhlmann JD, Wimberger P, Grützmann K, Herzog N, Küpper JH, O’Reilly M, Kabir SN, Sommerfeld LC, Guan K, Wielockx B, Fabritz L, Nattel S, Ravens U, Dobrev D, Wagner M, El-Armouche A
Cirulation Res, 2021 Oct, 12 (8): 804-820, Epub 2021 Aug 26, doi: 10.1161/CIRCRESAHA.121.319425.IF-17,367 MNiSW-200
7-[[(4-methyl-2-pyridinyl)amino](2-pyridinyl)methyl]-8-quinolinol (compound 30666) inhibits enhancer activity and reduces B-cell lymphoma growth - A question of specificity.
Kasprzyk ME, Łosiewski W, Podralska M, Kazimierska M, Sura W, Dzikiewicz-Krawczyk A
IF-4,432 MNiSW-100
Polymorphism in BACH2 gene is a marker of polyglandular autoimmunity.
Fichna M, Żurawek M, Słomiński B, Sumińska M, Czarnywojtek A, Rozwadowska N, Fichna P, Myśliwiec M, Ruchała M
Endocrine, 2021 Oct, 74 (1): 72-79, Epub May 8. doi: 10.1007/s12020-021-02743-9IF-3,633 MNiSW-100
The most frequent ATM mutations are not susceptibility factors for tobacco-related cancers
Podralska M, Dzikiewicz-Krawczyk A, Mosor M, Żurawek M, Iżykowska K, Słomski R, Rydzanicz M, Gabryel P, Dyszkiewicz W, Ziółkowska-Suchanek I
Arch Med Sci, 2021, 17 (5): 1158-1163, Epub 2020 Apr 8, doi 10.5114/aoms.2020.94155IF-3,318 MNiSW-70
Mitochondria Content and Activity Are Crucial Parameters for Bull Sperm Quality Evaluation
Madeja ZE, Podralska M, Nadel A, Pszczoła M, Pawlak P and Rozwadowska N.
Antioxidants (MDPI), 2021, 10 (8), e1204; 24 str, doi.10.3390/antiox10081204IF-6,312 MNiSW-100
Methylation patterns of cutaneous T-cell lymphomas
Iżykowska K.
Experimental Dermatol, 2021, 30 (8): 1135-1140, Epub 2020 Apr 30. doi: 10.1111/exd.14108IF-3,960 MNiSW-100
Enhancing B-Cell Malignancies-On Repurposing Enhancer Activity towards Cancer.
Kasprzyk ME, Sura W, Dzikiewicz-Krawczyk A
Cancers (MDPI), 2021 Jun 29;13(13) e3270, 35 stron doi: 10.3390/cancers13133270IF-6,639 MNiSW-140
Overexpression of miR-7977 in CD4+ T cells is associated with multiplex autoimmunity in patients with Addison’s disease.
Fichna M, Zurawek M, Fichna JP, Ruchała M
Eur J Endocrinol, 2021 May 28, 185 (1): 145-151, epub 2021 May 1, doi: 10.1530/EJE-21-0007IF-6,664 MNiSW-140
Overexpression of miR-7977 in CD4+ T cells is associated with multiplex autoimmunity in patients with Addison's disease.
Fichna M, Żurawek M, Fichna JP, Ruchala M
Eur J Endocrinol, 2021 May 28, 185 (1): 145-151, Epub 2021 May 1, doi: 10.1530/EJE-21-0007IF-5,308 MNiSW-140
The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, RB1 and ERBB2 Somatic Mutations.
Kałużewski T, Przybylski GK, Bednarek M, Glazar S, Grabiec M, Jędrzejczyk A, Kępczyński Ł, Kubiak I, Kucharska D, Morel A, Owczarek M, Rożniecki M, Sałamunia J, Szewczyk D, Szwalski J, Kałużewski B
J Personal Med, 2021 Apr 30;11 (5):e362, 18 str., doi: 10.3390/jpm11050362.IF-4,433 MNiSW-70
All publications
Featured research projects
1. Research project
“Identification of genes responsible for the development of Sezary syndrome by genome and transcriptome sequencing.”
Duration: 29 August 2013 – 28 August 2016
2. Research project
“Role of genes which affect tissue availability and local action of glucocorticoids in the development of insulin resistance and type 2 diabetes risk in obese children and adolescents.”
Duration: May 2013 – May 2016
3. Research project
“BCL11B gene – potential therapeutic target in T-cells malignancies.”
Duration: 20 February 2014 – 19 February 2017
4. Research project
“Microarray analysis of miRNA expression for identifying the molecular markers of type 1 diabetes.”
Duration: May 2015 – May 2018
5. Functional dissection of IGH regulatory regions in B-cell non-Hodgkin lymphoma
The goal of the project is to identify and characterize the functional elements in IGH regulatory regions and enhancer RNAs (eRNA) essential for B-cell lymphoma cell growth. We use state of the art techniques such as RISPR/Cas9 screens, GRO-seq, chromatin immunoprecipitation. This project is performed in collaboration with scientists from the Netherlands and the US.
EU Contribution: 1 952 960,00 PLN
Duration: 01.01.2019 – 31.12.2021
Collaborations
Department of Internal Medicine and Diabetology, Poznań University of Medical Sciences, Poznań, Poland.
Department of Endocrinology, Metabolism and Internal Diseases, Poznań University of Medical Sciences, Poznań, Poland.
Department of Preventive Medicine, Poznań University of Medical Sciences, Poznań, Poland.
Department of Paediatric Diabetes and Obesity, Poznań University of Medical Sciences, Poznań, Poland.
Department of Infectious Diseases, Poznań University of Medical Sciences, Poznań, Poland.
Department of Paediatric Oncology, Haematology and Bone Marrow Transplantation, Poznań University of Medical Sciences, Poznań, Poland.
Department of Pulmonology, Allergology and Respiratory Oncology, Poznań University of Medical Sciences, Poznań, Poland.
Department of Thoracic Surgery, Poznań University of Medical Sciences, Poznań, Poland.
Neuroimmunological Unit, Mossakowski Medical Research Centre, Polish Academy of Sciences.
Clinic for Internal Medicine C, University of Greifswald, Greifswald, Germany.
Department of Clinical Science, University of Bergen, Norway.
Department of Dermatology, Leiden University Medical Centre, Leiden, Netherlands.
Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom.
Laboratory of Genome Maintenance, Rockefeller University, New York, NY, United States of America.
Veterinary Genetics Group, Vetsuisse-Faculty of Zurich, University of Zurich, Switzerland.
Awards
Awarded:
dr n. med. Iwona Ziółkowska-Suchanek
Aegean Conference Travel Award
Given by: 7th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets.
Lecture: “Hypoxia-induced FAM13A modulates lung cancer cells growth, metastatic potential and actin cytoskeleton organization”. 7th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets. Kos, Grecja, 18-25.09.2021 r.
Awarded:
mgr inż. Marta Kazimierska
Scholarship
Given by: Director IBCH PAS
Scholarship 2020/21
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Polish Intelligent Development Award 2020 in the category: Scientist of the future
Given by: Intelligent Development Center
Prof. Grzegorz Przybylski M.D., Ph.D. became a laureate of the Polish Intelligent Development Award 2020 in the category: Scientist of the future for the realization of projects: “Double impact of BCL11B gene suppression for the targeted therapy of T-cell neoplasms”, “Elucidating the function of the transmembrane protein TMEM244 and its role in the development of lymphoid malignancies” and “BCL11B - Potential Therapeutic Target in T cell Neoplasms”.
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Nomination for the Polish Intelligent Development Award 2020
Given by: The Center of Intelligent Development
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: “Double impact of BCL11B gene suppression for the targeted therapy of T-cell neoplasms”, funded by the NCBiR.
Awarded:
dr n. med. Tomasz Kolanowski
Distinction for an oral presentation, XXIII Symposium of Experimental Cardiology Section of the Polish Cardiac Society and the Committee of Physiological and Pharmacological Sciences, Polish Academy of Sciences, 15-17.11.2018.
Given by: XXIII Symposium of Experimental Cardiology Section of the Polish Cardiac Society and the Committee of Physiological and Pharmacological Sciences, Polish Academy of Sciences
Distinction for an oral presentation.
Awarded:
dr hab. n. med. Natalia Rozwadowska
Prime Minister Award
Given by: Prime Minister
Prof. Natalia Rozwadowska has been honored with Prime Minister Award for the habilitation dissertation entitled “Molecular characterization and genetic modification of muscle stem cells as an approach to regenerative therapy”. Among of this year's the Award laureates, achievement of prof. Natalia Rozwadowska is the only affiliated to Polish Academy of Sciences.
Awarded:
dr hab. n. med. Agnieszka Dzikiewicz-Krawczyk
FIRST TIME
FIRST TIME
Given by: Fundacja Nauki Polskiej
Do konkursu zgłoszono 131 wniosków, z których 13 zostało zarekomendowanych do finansowania ze środków z Programu Operacyjnego Inteligentny Rozwój (PO IR) Fundacji Nauki Polskiej, wśród nich znalazł się projekt dr Agnieszki Dzikiewicz-Krawczyk pt. "Funkcjonalna analiza regionu regulatorowego genu IGH w chłoniakach nieziarniczych z komórek B".
Awarded:
dr n. med. Ewelina Kałużna
Stypendium ETIUDA, 18.07.2018 r.
Stypendium ETIUDA, 18.07.2018 r.
Staż w zagranicznym ośrodku naukowym przez okres 6 miesięcy (University of North Carolina at Chapel Hill).
Given by: Narodowe Centrum Nauki
Tytuł projektu: "Ekspresja i oddziaływanie wybranych miRNA z docelowymi mRNA w przewlekłym wirusowym zapaleniu wątroby typu C".
Awarded:
mgr inż. Bogna Świątek-Kościelna
2nd place in the best short report competition during the 7th Open Lectures held within the framework of Young Scientists' Meeting in Poznan.
Given by: "Biosfere" Students' Research Club and the Department of Clinical Chemistry and Molecular Diagnostics.
Presentation: "Expression of the TP53 gene in patients with chronic viral hepatitis C treated with pegylated interferon alpha and ribavirin". Poznan, 9 April 2016.
Awarded:
Jolanta Rembowska
Medal Złoty
Given by: Prezydent RP
Medal za Długoletnią Służbę. Wręczenie odznaczenia odbyło się podczas uroczystości z okazji jubileuszu 40-lecia Instytutu Genetyki Człowieka PAN w Poznaniu, 25.06.2014 r.