The department’s research includes molecular-genetic aspects of cancer, autoimmune and infectious diseases. Mutations and polymorphisms in cancer risk genes are also analysed, as well as genomic rearrangements and chromosomal aberrations in leukaemias, breast, larynx, lung and colon cancers. We also investigate the role of polymorphisms of risk genes in the development of diabetes, multiple sclerosis (MS) and Addison's disease, as well as carrying out a search for genetic markers of hepatitis C virus (HCV) elimination and the effectiveness of therapy for patients with viral hepatitis C.
Department of Molecular Pathology
Featured publications
Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers.
Wargocka-Matuszewska W, Uhrynowski W, Rozwadowska N, Rogulski Z
Int J Mol Sci (MDPI), 2022 Dec 26, 24 (1): 353., 31 str., doi: 10.3390/ijms24010353IF-6.208 MNiSW-140
The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cells.
Winkle M, Tayari MM, Kok K, Duns G, Grot N, Kazimierska M, Seitz A, Jong D, Koerts J, Diepstra A, Dzikiewicz-Krawczyk A, Steidl C, Kluiver J, van den Berg A
IF-5,121
Punkty-140
IF-5,121 MNiSW-140
Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia
Malcher A, Stokowy T, Berman A, Olszewska M, Jedrzejczak P, Sielski D, Nowakowski A, Rozwadowska N, Yatsenko A.N, Kurpisz M.K
IF-4,456 MNiSW-140
C10orf55, CASC2, and SFTA1 lncRNAs Are Potential Biomarkers to Assess Radiation Therapy Response in Head and Neck Cancers
Paszkowska A, Kolenda T, Guglas K, Kozłowska-Masłoń J, Podralska M, Teresiak A, Bliźniak R, Dzikiewicz-Krawczyk A, Lamperska K
J Person Med (MDPI), .2022 Oct, 12 (10): 1696, 18 str,IF-3,508 MNiSW-70
Adar-mediated A-to-I editing is required for embryonic patterning and innate immune response regulation in zebrafish
Niescierowicz K, Pryszcz L, Navarrete C, Tralle E, Sulej A, Abu Nahia K, Kasprzyk ME, Misztal K, Pateria A, Pakuła A, Bochtler M, Winata C
Nat Commun, 2022 Sept 20, 13 (1): 5520IF-17,694 MNiSW-200
Modeling the human heart ex vivo-current possibilities and strive for future applications
Kałużna E, Nadel A, Zimna A, Rozwadowska N, Kolanowski T
IF-4,323 MNiSW-140
Effect of miR-195 inhibition on human skeletal muscle-derived stem/progenitor cells
Nowaczyk M, Malcher A, Zimna A, Rozwadowska N, Kurpisz M
Kardiol Pol. 2022;80(7-8):813-824. doi: 10.33963/KP.a2022.0127. Epub 2022 May 13.IF-3,710 MNiSW-100
Role of Histone Deacetylases in T-Cell Development and Function.
Pieniawska M, Iżykowska K
Int J Mol Sci (MDPI), 2022 Jul 15; 23 (14): 7828., 22 strony, doi: 10.3390/ijms23147828.IF- 6,208 MNiSW-140
High expression of TMEM244 is associated with poor overall survival of patients with T-cell lymphoma.
Chen C, Chen S, Luo G, Wang L, Zeng C, Przybylski GK, Li Y
Biomarker Res, 2022 Jul 12;10 (1):46, 4 strony, doi: 10.1186/s40364-022-00395-zIF-8,633 MNiSW-100
Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model.
Przybylski GK, Korsak D, Iżykowska K, Nowicka K, Zalewski T, Tubacka M, Mosor M, Januszkiewicz-Lewandowska D, Frydrychowicz M, Boruczkowski M, Dworacki G, van den Brandt J, Grabarczyk P, Schmidt CA, Zeng C, Li Y
Int J Mol Sci (MDPI) 2022 Apr 29; 2022, 23 (9):4932, 10 stron, doi: 10.3390/ijms23094932IF-5,924 MNiSW-140
All publications
Featured research projects
1. Research project
“Identification of genes responsible for the development of Sezary syndrome by genome and transcriptome sequencing.”
Duration: 29 August 2013 – 28 August 2016
2. Research project
“Role of genes which affect tissue availability and local action of glucocorticoids in the development of insulin resistance and type 2 diabetes risk in obese children and adolescents.”
Duration: May 2013 – May 2016
3. Research project
“BCL11B gene – potential therapeutic target in T-cells malignancies.”
Duration: 20 February 2014 – 19 February 2017
4. Research project
“Microarray analysis of miRNA expression for identifying the molecular markers of type 1 diabetes.”
Duration: May 2015 – May 2018
5. Functional dissection of IGH regulatory regions in B-cell non-Hodgkin lymphoma
The goal of the project is to identify and characterize the functional elements in IGH regulatory regions and enhancer RNAs (eRNA) essential for B-cell lymphoma cell growth. We use state of the art techniques such as RISPR/Cas9 screens, GRO-seq, chromatin immunoprecipitation. This project is performed in collaboration with scientists from the Netherlands and the US.
EU Contribution: 1 952 960,00 PLN
Duration: 01.01.2019 – 31.12.2021
Collaborations
Department of Internal Medicine and Diabetology, Poznań University of Medical Sciences, Poznań, Poland.
Department of Endocrinology, Metabolism and Internal Diseases, Poznań University of Medical Sciences, Poznań, Poland.
Department of Preventive Medicine, Poznań University of Medical Sciences, Poznań, Poland.
Department of Paediatric Diabetes and Obesity, Poznań University of Medical Sciences, Poznań, Poland.
Department of Infectious Diseases, Poznań University of Medical Sciences, Poznań, Poland.
Department of Paediatric Oncology, Haematology and Bone Marrow Transplantation, Poznań University of Medical Sciences, Poznań, Poland.
Department of Pulmonology, Allergology and Respiratory Oncology, Poznań University of Medical Sciences, Poznań, Poland.
Department of Thoracic Surgery, Poznań University of Medical Sciences, Poznań, Poland.
Neuroimmunological Unit, Mossakowski Medical Research Centre, Polish Academy of Sciences.
Clinic for Internal Medicine C, University of Greifswald, Greifswald, Germany.
Department of Clinical Science, University of Bergen, Norway.
Department of Dermatology, Leiden University Medical Centre, Leiden, Netherlands.
Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom.
Laboratory of Genome Maintenance, Rockefeller University, New York, NY, United States of America.
Veterinary Genetics Group, Vetsuisse-Faculty of Zurich, University of Zurich, Switzerland.
Awards
Awarded:
mgr Monika Pieniawska
Wyróżnienie pracy w sesji prac eksperymentalnych - Forum Młodych Polskiego Towarzystwa Dermatologicznego.
Given by: Polskie Towarzystwo Dermatologiczne
Wyróżnienie pracy w sesji prac eksperymentalnych pt.: Znaczenie nadekspresji deacytelazy histonowej klasy II HDAC10 w Zespole Sezary’ego. Forum Młodych Polskiego Towarzystwa Dermatologicznego. Łódź, 20-21.10.2022 r. (Pieniawska M, Rassek K, Skwara B, Zurawek M, Ziółkowska-Suchanek I, Podralska M, Nowicka K, Rozwadowska N, Iżykowska K)
Awarded:
mgr Marta Kasprzyk
As part of the award Marta was selected to present her poster in form of a short talk
Given by: 4th International Conference on the Long and the Short of Non-Coding RNAs
As part of the award Marta was selected to present her poster in form of a short talk:
“Functional dissection of IGH enhancers and enhancer RNAs in B-cell lymphomas”
Contributors: Marta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Marta Podralska, Marta Kazimierska, Tomasz Woźniak, Natalia Rozwadowska, Agnieszka Dzikiewicz-Krawczyk
The presented research is a result of the FIRST-TEAM POIR.04.04.00-00-5EC2/18-00 programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund, granted to prof. Agnieszka Dzikiewicz-Krawczyk
Awarded:
mgr Marta Kasprzyk
Helisa 2022
Given by: Polish Society of Human Genetics, VI Polish Genetics Congress, Cracow on June 27-30th, 2022.
for the best posters presented on the Human Genetics session: Marta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Marta Podralska, Marta Kazimierska, Tomasz Woźniak, Natalia Rozwadowska, Agnieszka Dzikiewicz-Krawczyk - Functional dissection of IGH enhancers and enhancer RNAs in B-cell lymphomas.
Awarded:
dr hab. n. med. Iwona Ziółkowska-Suchanek
Aegean Conference Travel Award
Given by: 7th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets.
Lecture: “Hypoxia-induced FAM13A modulates lung cancer cells growth, metastatic potential and actin cytoskeleton organization”. 7th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets. Kos, Grecja, 18-25.09.2021 r.
Awarded:
dr n. med. Marta Kazimierska
Scholarship
Given by: Director IBCH PAS
Scholarship 2020/21
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Polish Intelligent Development Award 2020 in the category: Scientist of the future
Given by: Intelligent Development Center
Prof. Grzegorz Przybylski M.D., Ph.D. became a laureate of the Polish Intelligent Development Award 2020 in the category: Scientist of the future for the realization of projects: “Double impact of BCL11B gene suppression for the targeted therapy of T-cell neoplasms”, “Elucidating the function of the transmembrane protein TMEM244 and its role in the development of lymphoid malignancies” and “BCL11B - Potential Therapeutic Target in T cell Neoplasms”.
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Nomination for the Polish Intelligent Development Award 2020
Given by: The Center of Intelligent Development
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: “Double impact of BCL11B gene suppression for the targeted therapy of T-cell neoplasms”, funded by the NCBiR.
Awarded:
dr n. med. Tomasz Kolanowski
Distinction for an oral presentation, XXIII Symposium of Experimental Cardiology Section of the Polish Cardiac Society and the Committee of Physiological and Pharmacological Sciences, Polish Academy of Sciences, 15-17.11.2018.
Given by: XXIII Symposium of Experimental Cardiology Section of the Polish Cardiac Society and the Committee of Physiological and Pharmacological Sciences, Polish Academy of Sciences
Distinction for an oral presentation.
Awarded:
dr hab. n. med. Natalia Rozwadowska
Prime Minister Award
Given by: Prime Minister
Prof. Natalia Rozwadowska has been honored with Prime Minister Award for the habilitation dissertation entitled “Molecular characterization and genetic modification of muscle stem cells as an approach to regenerative therapy”. Among of this year's the Award laureates, achievement of prof. Natalia Rozwadowska is the only affiliated to Polish Academy of Sciences.
Awarded:
dr hab. n. med. Agnieszka Dzikiewicz-Krawczyk
FIRST TIME
FIRST TIME
Given by: Fundacja Nauki Polskiej
Do konkursu zgłoszono 131 wniosków, z których 13 zostało zarekomendowanych do finansowania ze środków z Programu Operacyjnego Inteligentny Rozwój (PO IR) Fundacji Nauki Polskiej, wśród nich znalazł się projekt dr Agnieszki Dzikiewicz-Krawczyk pt. "Funkcjonalna analiza regionu regulatorowego genu IGH w chłoniakach nieziarniczych z komórek B".