The department’s research includes molecular-genetic aspects of cancer, autoimmune and infectious diseases. Mutations and polymorphisms in cancer risk genes are also analysed, as well as genomic rearrangements and chromosomal aberrations in leukaemias, breast, larynx, lung and colon cancers. We also investigate the role of polymorphisms of risk genes in the development of diabetes, multiple sclerosis (MS) and Addison's disease, as well as carrying out a search for genetic markers of hepatitis C virus (HCV) elimination and the effectiveness of therapy for patients with viral hepatitis C.
Department of Molecular Pathology
Featured publications
FOXP3: A player of immunogenetic Architecture in Lung Cancer.
Ziółkowska-Suchanek I, Zurawek M
Genes, 2024, 15, 4: 493, doi: 10.3390/genes15040493.IF-3.5
Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR‑150 binding capacity.
Liu Y, Zhao X, Seitz A, Hooijsma AA, Ravanbakhsh R, Sheveleva S, de Jong D, Koerts J, Dzikiewicz-Krawczyk A, van den Berg A, Ziel-Swier LJYM, Kluiver J
Sci Rep, 2024 Apr 16;14(1):8730. doi: 10.1038/s41598-024-59443-3IF-4.6 MNiSW-140
T-cell lymphoma patient harboring BCL11B mutations had favorable overall survival.
Chen C, Huang L, Liu S, Jiang X, Chen F, Wei X, Guo H, Zeng X, Zeng C, Przybylski GK, Li W, Li Y
Asia Pac J Clin Oncol, 2024 Feb; 20 (1): 81-86. doi: 10.1111/ajco.14000. Epub 2023 Aug 27.IF-1.9 MNiSW-40
Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage.
Podralska M, Sajek MP, Bielicka A, Żurawek M, Ziółkowska-Suchanek I, Iżykowska K, Kolenda T, Kazimierska M, Kasprzyk ME, Sura W, Pietrucha B, Cukrowska B, Rozwadowska N, Dzikiewicz-Krawczyk A
IF-3.8
Punkty-140
IF-3,8 MNiSW-140
BCL11B promotes T-cell acute lymphoblastic leukaemia cell survival via the XRCC5/C11ORF21 axis.
Yu X, Li Y, Yang P, Wang Y, Liu X, Cai L, Lai J, Zhang Y, Zha X, Przybylski GK, Xu L, Li Y
Clin Transl Med. 2024 Feb;14(2):e1580. doi: 10.1002/ctm2.1580IF-10,6 MNiSW-20
Inhibition of the glutamate cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells.
Kazimierska M,·Leśniewska A, Bakker A, Diepstra A, Kasprzyk ME, Podralska M, Rassek K, Kluiver J, van den Berg A, Rozwadowska N, Dzikiewicz Krawczyk A
J Appl Genet, 2024 Feb, 65 (1): 95-101, doi.10.1007/s13353-023-00797-1, Epub 2023 Nov 2IF-2.4 MNiSW-140
BCL11B Mutations Are Associated with Higher CD8+ T-Cell Percentage and Favorable Clinical Outcomes in Patients with T-Cell Acute Lymphoblastic Leukemia.
Chen C, Zhang Y, Zeng X, Zeng Ch, Przybylski GK, Li Y
Clinical Medicine Insights-Oncology, 2023, 17: 1-3; 10.1177/11795549231216427.IF-2.2 MNiSW-100
CRISPR/Cas9 screen for genome-wide interrogation of essential MYC-bound E-boxes in cancer cells.
Kazimierska M, Podralska M, Żurawek M, Woźniak T, Kasprzyk ME, Sura W, Łosiewski W, Ziółkowska-Suchanek I, Kluiver J, van den Berg A, Rozwadowska N, Dzikiewicz-Krawczyk A
Molec Oncol, Epub 2023 Nov, 17 (11): 2295-2213, doi: 10.1002/1878-0261.13493, Epub Aug 7IF-6.6 MNiSW-140
Cardiac post-chest radiotherapy complications in a 50-year-old patient with Hodgkin Lymphoma.
Klotzka A, Sobańska K, Iwańczyk S, Grygier M, Woźniak P, Błaszyk M, Rozwadowska N, Lesiak M
J Clin Med, 2023, 12, 6506, doi: 10.3390/jcm12206506IF-3.9 MNiSW-140
Hybrids of manganese oxide and lipid liquid crystalline nanoparticles (LLCNPs@MnO) as potential magnetic resonance imaging (MRI) contrast agents.
Flak D, Zalewski T, Fiedorowicz K, Przysiecka Ł, Jarek M, Klimaszyk A, Kempka M, Zimna A, Rozwadowska N, Avaro J, Liebi M, Nowaczyk G
J Mater Chem B, 2023 Sep 20, 11 (36): 8732-53, doi: 10.1039/d3tb01110k.Epub Sep 1.140IF-7,0 MNiSW-140
All publications
Featured research projects
1. Research project
“Identification of genes responsible for the development of Sezary syndrome by genome and transcriptome sequencing.”
Duration: 29 August 2013 – 28 August 2016
2. Research project
“Role of genes which affect tissue availability and local action of glucocorticoids in the development of insulin resistance and type 2 diabetes risk in obese children and adolescents.”
Duration: May 2013 – May 2016
3. Research project
“BCL11B gene – potential therapeutic target in T-cells malignancies.”
Duration: 20 February 2014 – 19 February 2017
4. Research project
“Microarray analysis of miRNA expression for identifying the molecular markers of type 1 diabetes.”
Duration: May 2015 – May 2018
5. Functional dissection of IGH regulatory regions in B-cell non-Hodgkin lymphoma
The goal of the project is to identify and characterize the functional elements in IGH regulatory regions and enhancer RNAs (eRNA) essential for B-cell lymphoma cell growth. We use state of the art techniques such as RISPR/Cas9 screens, GRO-seq, chromatin immunoprecipitation. This project is performed in collaboration with scientists from the Netherlands and the US.
EU Contribution: 1 952 960,00 PLN
Duration: 01.01.2019 – 31.12.2021
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Collaborations
Department of Internal Medicine and Diabetology, Poznań University of Medical Sciences, Poznań, Poland.
Department of Endocrinology, Metabolism and Internal Diseases, Poznań University of Medical Sciences, Poznań, Poland.
Department of Preventive Medicine, Poznań University of Medical Sciences, Poznań, Poland.
Department of Paediatric Diabetes and Obesity, Poznań University of Medical Sciences, Poznań, Poland.
Department of Infectious Diseases, Poznań University of Medical Sciences, Poznań, Poland.
Department of Paediatric Oncology, Haematology and Bone Marrow Transplantation, Poznań University of Medical Sciences, Poznań, Poland.
Department of Pulmonology, Allergology and Respiratory Oncology, Poznań University of Medical Sciences, Poznań, Poland.
Department of Thoracic Surgery, Poznań University of Medical Sciences, Poznań, Poland.
Neuroimmunological Unit, Mossakowski Medical Research Centre, Polish Academy of Sciences.
Clinic for Internal Medicine C, University of Greifswald, Greifswald, Germany.
Department of Clinical Science, University of Bergen, Norway.
Department of Dermatology, Leiden University Medical Centre, Leiden, Netherlands.
Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom.
Laboratory of Genome Maintenance, Rockefeller University, New York, NY, United States of America.
Veterinary Genetics Group, Vetsuisse-Faculty of Zurich, University of Zurich, Switzerland.
Awards
Awarded:
Given by:
Awarded:
dr n. med. i n. o zdr. Karolina Rassek
Stypendium Naukowe Miasta Poznania dla młodych badaczy z poznańskiego środowiska naukowego za wyróżniający się dorobek naukowy w zakresie badania molekularnych mechanizmów leżących u podstaw chłoniaków skórnych T-komórkowych.
Stypendium Naukowe Miasta Poznania dla młodych badaczy z poznańskiego środowiska naukowego za wyróżniający się dorobek naukowy w zakresie badania molekularnych mechanizmów leżących u podstaw chłoniaków skórnych T-komórkowych.
Given by: Stypendium Naukowe Miasta Poznania
Stypendia naukowe Miasta Poznania przyznawane są wyróżniającym się badaczom, wykazującym się sukcesami w swojej dziedzinie nauki.
Awarded:
dr n. med. i n. o zdr. Karolina Rassek
In the competition for the best original work of a doctoral student in 2022 organized by The Poznan Branch of the Polish Academy of Sciences, MSc Karolina Rassen received an honorable mention for the publication in the field of medical sciences.
Given by: The Poznan Branch of the Polish Academy of Sciences,
Rassek K., Iżykowska K., Żurawek M, Nowicka K., Joks M., Olek-Hrab K., Olszewska B., Sokołowska- Wojdyło M., Biernat W., Nowicki R.J., G.K. Przybylski, TMEM244 Gene Expression as a Potential Blood Diagnostic Marker Distinguishing Sézary Syndrome from Mycosis Fungoides and Benign Erythroderma, J Invest Dermatol. 2022 Sep 8;S0022-202X(22)01899-1.doi: 10.1016/j.jid.2022.08.046.
Awarded:
mgr Monika Pieniawska
Main prize of Prof. Kazimierz Ostrowski
Given by: XIV National Conference on Advances in Biomedical Research
oral presentation entitled "Influence of histone deacetylase 10 overexpression on cancer cell biology in Sezary Syndrome".
Awarded:
mgr Monika Pieniawska
Wyróżnienie pracy w sesji prac eksperymentalnych - Forum Młodych Polskiego Towarzystwa Dermatologicznego.
Given by: Polskie Towarzystwo Dermatologiczne
Wyróżnienie pracy w sesji prac eksperymentalnych pt.: Znaczenie nadekspresji deacytelazy histonowej klasy II HDAC10 w Zespole Sezary’ego. Forum Młodych Polskiego Towarzystwa Dermatologicznego. Łódź, 20-21.10.2022 r. (Pieniawska M, Rassek K, Skwara B, Zurawek M, Ziółkowska-Suchanek I, Podralska M, Nowicka K, Rozwadowska N, Iżykowska K)
Awarded:
mgr Marta Kasprzyk
As part of the award Marta was selected to present her poster in form of a short talk
Given by: 4th International Conference on the Long and the Short of Non-Coding RNAs
As part of the award Marta was selected to present her poster in form of a short talk:
“Functional dissection of IGH enhancers and enhancer RNAs in B-cell lymphomas”
Contributors: Marta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Marta Podralska, Marta Kazimierska, Tomasz Woźniak, Natalia Rozwadowska, Agnieszka Dzikiewicz-Krawczyk
The presented research is a result of the FIRST-TEAM POIR.04.04.00-00-5EC2/18-00 programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund, granted to prof. Agnieszka Dzikiewicz-Krawczyk
Awarded:
mgr Marta Kasprzyk
Helisa 2022
Given by: Polish Society of Human Genetics, VI Polish Genetics Congress, Cracow on June 27-30th, 2022.
for the best posters presented on the Human Genetics session: Marta Kasprzyk, Weronika Sura, Wojciech Łosiewski, Marta Podralska, Marta Kazimierska, Tomasz Woźniak, Natalia Rozwadowska, Agnieszka Dzikiewicz-Krawczyk - Functional dissection of IGH enhancers and enhancer RNAs in B-cell lymphomas.
Awarded:
dr hab. n. med. i n. o zdr. Iwona Ziółkowska-Suchanek
Aegean Conference Travel Award
Given by: 7th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets.
Lecture: “Hypoxia-induced FAM13A modulates lung cancer cells growth, metastatic potential and actin cytoskeleton organization”. 7th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets. Kos, Grecja, 18-25.09.2021 r.
Awarded:
dr n. med. Marta Kazimierska
Scholarship
Given by: Director IBCH PAS
Scholarship 2020/21
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Polish Intelligent Development Award 2020 in the category: Scientist of the future
Given by: Intelligent Development Center
Prof. Grzegorz Przybylski M.D., Ph.D. became a laureate of the Polish Intelligent Development Award 2020 in the category: Scientist of the future for the realization of projects: “Double impact of BCL11B gene suppression for the targeted therapy of T-cell neoplasms”, “Elucidating the function of the transmembrane protein TMEM244 and its role in the development of lymphoid malignancies” and “BCL11B - Potential Therapeutic Target in T cell Neoplasms”.