I have been working in the Institute of Human Genetics PAS since 2008. As a PhD student I performed functional studies of heterozygous mutations in the NBN gene, which encodes a protein involved in DNA double-strand break repair. After obtaining PhD in 2012, I moved to study the non-coding RNAs in hematological malignancies. In 2015-2016 I was a post-doctoral fellow at the University Medical Centre Groningen, the Netherlands, in the group of prof. Anke van den Berg. I studied the role of microRNA and long non-coding RNA in B-cell lymphoma. Back in the Institute, I continue this line of research in collaboration with prof. van den Berg. I am particularly interested in MYC-regulated non-coding RNA and to study them I use high-throughput screening approaches using shRNA and CRISPR/Cas9.

Publications

NGS-based high-throughput screen to identify microRNAs regulating growth of B-cell lymphoma.

Kluiver J, Niu F, Yuan Y, Kok K, van der Berg A, Dzikiewicz-Krawczyk A;

W: R. R. Küppers (editor), seria monografii: “Methods in Molecular Biology”: Lymphoma (2nd edition), Chapter 12, str. 269-282, Springer, Methods Mol Biol. 2019;1956:269-282. doi: 10.1007/978-1-4939-9151-8_12.

Events

Date:
18-19 Sep 2017
Where:
Poznan, Poland

RNAtion – Computational and Experimental RNA Biology Conference for Young Scientists
Oral presentation: Two faces of RNA: unraveling the role of protein-coding and non-coding ZDHHC11/B transcripts in Burkitt lymphoma

Date:
13-16 Sep 2017
Where:
Heidelberg, Germany

, EMBO|EMBL Symposium: The Non-Coding Genome
Oral presentation: ZDHHC11 and ZDHHC11B are novel critical components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma

Date:
21-24 Feb 2016
Where:
Santa Fe, USA

Keystone Symposium: Noncoding RNAs in Health and Disease
Poster: Identification of target genes of the MYC-repressed tumor supressor miRNA-150 in Burkitt lymphoma

Date:
20-22 Jan 2016
Where:
Papendal , The Netherlands

10th Dutch Hematology Congress
Oral presentation : Identification of target genes of the MYC-repressed tumor supressor miRNA-150 in Burkitt lymphoma

Date:
11-15 June 2014
Where:
Milan, Italy

19th Congress of the European Hematology Association
Poster : A functional polymorphism in the 3’ untranslated region of the ARHGAP26 gene confers an increased risk of chronic myeloid leukemia and causes illegitimate regulation by microRNA-18a-3p

Date:
10-13 Sep 2013
Where:
Poznan, Poland

4th Polish Congress of Genetics
Oral presentation: MicroRNA binding sites polymorphisms and the risk of pediatric acute lymhoblastic leukemia and adult myeloid leukemias

Date:
12-15 Sep 2010
Where:
Lublin, Poland

3rd Polish Congress of Genetics
Poster: Impact of heterozygous NBN gene mutations on nibrin functions

Awards

Awarded: dr hab. n. med. Agnieszka Dzikiewicz-Krawczyk
FIRST TIME
Given by: Fundacja Nauki Polskiej

Do konkursu zgłoszono 131 wniosków, z których 13 zostało zarekomendowanych do finansowania ze środków z Programu Operacyjnego Inteligentny Rozwój (PO IR) Fundacji Nauki Polskiej, wśród nich znalazł się projekt dr Agnieszki Dzikiewicz-Krawczyk pt. "Funkcjonalna analiza regionu regulatorowego genu IGH w chłoniakach nieziarniczych z komórek B".