I am a graduate of Master Degree in Biotechnology at Adam Mickiewicz University in Poznan. I started cooperation with the Institute of Human Genetics PAS in the Department of Reproductive Biology and Stem Cells in 2009. From the beginning, my interest focused on the process of spermatogenesis and cell differentiation, including stem cells. I had the opportunity to participate in several projects related to microarrays to identify genes specifically dedicate for the molecular diagnosis of male infertility; as well as stem cell research in the context of myocardial regenerative therapy.
dr n. med. Agnieszka Malcher
Publications
ESX1 gene as a potential candidate responsible for male infertility in nonobstructive azoospermia.
Malcher A, Graczyk Z, Bauer H, Stokowy T, Berman A, Smolibowski M, Blaszczyk D, Jedrzejczak P, Yatsenko AN, Kurpisz M
Scient Rep, 2023 Oct 2;13 (1):16563, 14 stron, doi: 10.1038/s41598-023-43854-9IF-4.6 MNiSW-140
Genomic study of TEX15 variants: prevalence and allelic heterogeneity in men with spermatogenic failure.
Quershi S, Hardy JJ, Pombar C, Berman AJ, Malcher A, Gingrich T, Hvasta R, Juong J, Munyoki S, Hwang K, Orwig KE, Ahmed J, Olszewska M, Kurpisz M, Conrad DF, Khan MH, Yatsenko AN
Frontiers in Genetics, 2023, 14: 1134849, str. 1/13, doi: 10.3389/fgene.2023.1134849IF-3.7 MNiSW-100
Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia
Malcher A, Stokowy T, Berman A, Olszewska M, Jedrzejczak P, Sielski D, Nowakowski A, Rozwadowska N, Yatsenko A.N, Kurpisz M.K
IF-4,456 MNiSW-140
Effect of miR-195 inhibition on human skeletal muscle-derived stem/progenitor cells
Nowaczyk M, Malcher A, Zimna A, Rozwadowska N, Kurpisz M
Kardiol Pol. 2022;80(7-8):813-824. doi: 10.33963/KP.a2022.0127. Epub 2022 May 13.IF-3,710 MNiSW-100
Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis statuts.
Nowicka-Bauer K, Malcher A, Włoczkowska O, Kamieniczna M, Olszewska M, Kurpisz MK
Reproductive Biology, 2022, 100597, 1-7, doi: 10.1016/j.repbio.2021.100597IF-2,376 MNiSW-100
Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure.
Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieño-Enríquez MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O’Bryan MK, Conrad DF, Kurpisz M, Tüttelmann F, Yatsenko AN; GEMINI Consortium
Hum Genet, 2021 Aug;140 (8):1169-1182. doi: 10.1007/s00439-021-02287-y. Epub 2021 May 7.IF-4,132 MNiSW-100
Addition of Popular Exogenous Antioxidant Agent, PBN, to Culture Media May Be an Important Step to Optimization of Myogenic Stem/Progenitor Cell Preparation Protocol.
Nowaczyk M, Malcher A, Zimna A, Łabędź W˛ Kubaszewski Ł, Barczak W , Rubiś B, Rozwadowska N and Kurpisz M
Antioxidants (MDPI), 2021, 1 (6), e959, 17 stron, https://doi.org/10.3390/antiox10060959IF-100 MNiSW-6,312
Transient and Stable Overexpression of Extracellular Superoxide Dismutase Is Positively Associated with the Myogenic Function of Human Skeletal Muscle-Derived Stem/Progenitor Cells.
Nowaczyk M, Malcher A, Zimna A, Łabędź W, Kubaszewski Ł, Fiedorowicz K, Wierzbiński K, Rozwadowska N and Kurpisz M
IF-5,014 MNiSW-100
Co-Transplantation of Bone Marrow-MSCs and Myogenic Stem/Progenitor Cells from Adult Donors Improves Muscle Function of Patients with Duchenne Muscular Dystrophy (case report)/.
Klimczak A, Zimna A, Malcher A, Kozlowska U, Futoma K, Czarnota J, Kemnitz P, Bryl A and Kurpisz M
Cells 2020, 9(5), 1119; doi:10p.3390/cells9051119, 28 str.IF-4,366 MNiSW-140
Human skeletal muscle-derived stem/progenitor cells modified with connexin-43 prevent arrhythmia in rat-postinfarction hearts and influence gene expression in the myocardium.
Rugowska A, Wiernicki B, Maczewski M, Mackiewicz U, Chojnacka K, Bednarek-Rajewska K, Kluk A, Majewski P, Kolanowski T, Malcher A, Rozwadowska N, Kurpisz M
J Physiol Pharmacol, 2019, 70(6): 917-933, doi: 10.26402/jpp.2019.6.10. Epub 2020 Mar 20IF-2,544 MNiSW-70
All publications
Events
26-28.06.2014 Where:
Wrocław
15th Congress of the Polish Society of Experimental and Clinical Immunology
1-13.IX.2013 Where:
Poznań
IV Polish Congress of Genetics
XI.2012 Where:
Berlin
7th European Congress of Andrology (ECA)
16-23.10.2014 Where:
Honolulu, USA
ASRM-American Society for Reproductive Medicine 2014 Annual Meeting
1-13.IX.2013 Where:
Poznan
IV Polski Kongres Genetyki
13-15.05.2013 Where:
Barcelona, Hiszpania
6th Congress of the International Network for Young Researchers in Male Fertility
23-26.02. 2013 Where:
Melbourne, Australia
The 10th International Congress of Andrology
29.09 - 1.10.2011 Where:
Edynburg, UK
4th Congress of the International Network for Young Researchers in Male Fertility
8-10.09.2011 Where:
Polańczyk, Polska
VI Meeting of the Society for Reproductive Biology
Awards
Nomination for the Polish Inteligent Development Award 2019
Dr n. med. Agnieszka Malcher has been nominated for the Polish Intelligent Development Award 2019 in the category: Scientist of the future for the project: "Novel causative genetic variants in azoospermia: whole genome analysis and functional in vitro studies." The winners of this prestigious award have been for four years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.
Short-Term Fellowships
Short-Term Fellowships of European Molecular Biology Organization (EMBO) to implement the project CRISPR/Cas9 system based spermatogenesis impairment in vitro modeling of human male gonad. The research will be conducted in Max Planck Institute for Molecular Genetics in Germany.
mgr Kamil Wierzbiński
Tomasz Szymański
dr hab. n. med. Natalia Rozwadowska
dr n. med. Agnieszka Zimna
dr n. med. Karolina Nowicka-Bauer
dr n. med. Agnieszka Malcher
dr n. med. i n. o zdr. Magdalena Nowaczyk
prof. dr hab. n. med. Maciej Kurpisz
Nagroda za najlepszą prezentację konferencyjną.
Oral Presentation: “Potential use of superparamagnetic iron oxide nanoparticles for bioimaging of myoblasts in post-infarction heart stem cells therapy” during the XXI Symposium of the Section of Experimental Cardiology of Polish Cardiac Society and the Committee of Physiological Sciences and Pharmacology; Polish Academy of Sciences; Rynia, 13-15.10.2016.
Award of the Polish Academy of Sciences
For the best publication published in 2013: “Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.” Fertil Steril. 2013; 100(6): 1686–1694.e7, Poznan, 5 June 2014.
dr n. med. Agnieszka Malcher
dr hab. n. med. Natalia Rozwadowska
prof. dr hab. n. med. Maciej Kurpisz
"Golden Helix"
For the poster: “Potential diagnostic and prognostic biomarkers in patients with nonobstructive azoospermia identified by gene expression profile analysis” by A. Malcher, N. Rozwadowska, T. Stokowy, P. Jędrzejczak, W. Zietkowiak, M. Kurpisz. IV Polish Congress of Genetics, 1–13 September 2013, Poznań, Poland.
Scholarship
Project “Scholarship support for Ph.D. students specializing in majors strategic for Wielkopolska’s development”, Sub-measure 8.2.2 Human Capital Operational Programme, co-financed by the European Union under the European Social Fund. 2012-2013