prof. dr hab. n. biol. Jadwiga Jaruzelska - Institute of Human Genetics Polish Academy of Sciences

About me Publications Awards Contact

Professor Jadwiga Jaruzelska is a group leader at the Department of Nucleic Acids. Her research is focused on some aspects of regulation of gene expression in germ cells, in the context of male infertility. Her projects concern in particular the posttranscriptional regulatory mechanisms involving RNA-binding proteins, such as PUMILIO and its cofactors, which bind 3’ untranslated regions and in cooperation with the miRNA machinery determine the fate of specific mRNAs. In particular, mutated RNA-binding proteins from patients suffering from a failure of the reproductive system are used as molecular tools to study the basis of that mechanism and infertility. Another topic of her research is identification of novel genes implicated in human sex determination, in patients suffering from disorders of sex development (DSD). Professor Jaruzelska is the Polish coordinator of an international project addressing this issue. The project is conducted by the University of Geneva, in cooperation with the Institute of Human Genetics of the Polish Academy of Sciences in Poznań, Medical State University of Yerevan, National Academy of Sciences of Ukraine in Kyiv, Poznań University of Medical Sciences, and the Children’s Memorial Health Institute in Warsaw.

Professor Jaruzelska’s research is supported by grants she received from the National Science Center in Poland and the Swiss National Science Foundation.

Keywords: posttranslational gene regulation, RNA-binding proteins, microRNAs, germ cells, human sex determination, disorders of sex development

Lab members:
Kamila Kusz-Zamelczyk, PhD
Marcin Sajek, PhD
Krystyna Kwiatkowska, technician

Damian Janecki, PhD student
Maciej Śmiałek, PhD student
Erkut Ilaslan, PhD student

Current projects:

National Science Center Poland 2019/35/B/NZ1/01665 (2020-2024); NANOS1 RNP-interactome: structure and dynamics during specification/early stages of human germ cell development – significance for human reproduction (principal investigator)
National Science Center Poland OPUS 2013/09/B/NZ1/01878 (2013-2017); Global PUMILIO regulation of mRNAs and role of MAELSTROM, a nuage component and a cancer testis marker, in human seminoma (principal investigator)
Swiss National Science Foundation SCOPES number IZ73ZO_152347/1 (2013-2016); Genetics of human disorders of sexual development (Polish coordinator)

CV Jadwiga Jaruzelska

Publications

Emerging Roles of NANOS RNA-Binding Proteins in Cancer.

Ilaslan E, Sajek MP, Jaruzelska J, Kusz-Zamelczyk K

Int J Mol Sci (MDPI), 2022 Aug 20; 23 (16): 9408, 12 str,doi: 10.3390/ijms23169408.

IF-6,208 MNiSW-140

Distinct Roles of NANOS1 and NANOS3 in the Cell Cycle and NANOS3‐PUM1‐FOXM1 Axis to Control G2/M Phase in A Human Primordial Germ Cell Model.

Ilaslan E, Kwiatkowska K, Śmialek MJ, Sajek MP, Lemańska Ż, Alla M, Janecki DM, Jaruzelska J, Kusz‐Zamelczyk K

Int J Molec Sci (MDPI), 2022, 23 (12): 6592, 19 str, https://doi.org/10.3390/ijms23126592

IF-5,924 MNiSW-140

Special Issue on “Sex Determination Mechanisms and Disease”

Jaruzelska J, Kusz-Zamelczyk K, Bertelloni S (guest editors)

Int J Molec Sci (MDPI), closed Dec 30, published 2022, 3 articles

IF-5,923 MNiSW-80

A Novel WT1 Mutation Identified in a 46,XX Testicular/Ovotesticular DSD Patient Results in the Retention of Intron 9.

Sirokha D, Gorodna O,Vitrenko Y, Zelinska N, Ploski R, Nef S, Jaruzelska J, Kusz-Zamelczyk K and Ludmila Livshits L

Biology (MDPI), 2021, 10 (12), 1248,13 str, doi: 10.3390/biology10121248

IF-5,079 MNiSW-100

RNAlign2D – a rapid method for combined RNA structure and sequence-based alignment using a pseudo-amino acid substitution matrix.

Woźniak T, Sajek M, Jaruzelska J, Sajek MP

BMC Bioinformatics, 2021, 22, e504, 17 stron, doi: 10.1186/s2859-021-04426-8

IF-3,169 MNiSW-100

Role of PUM RNA-Binding Proteins in Cancer.

Smialek M, Ilaslan E, Sajek M, Jaruzelska J

Cancers 2021, 13 (1), 129; https://doi.org/10.3390/cancers13010129

IF-6,126 MNiSW-140

The FKBP4 gene, encoding a regulator of the androgen receptor signaling pathway, is a novel candidate gene for androgen insensitivity syndrome.

Ilaslan E, Markosyan R, Sproll P, Stevenson BJ, Sajek M, Sajek MP, Hayrapetyan H, Sarkisian T, Livshits L, Nef S, Jaruzelska J, Kusz-Zamelczyk K

Internatl J Molecular Sciences, 2020 Nov-1, e8403,11 str, doi:10.3390/ijms21218403

IF-4,556 MNiSW-140

Human NANOS1 Represses Apoptosis by Downregulating Pro-Apoptotic Genes in the Male Germ Cell Line.

Janecki DM, Ilaslan E, Śmiałek MJ, Sajek MP, Kotecki M, Ginter-Matuszewska B, Krainski P, Jaruzelska J, Kusz-Zamelczyk K

Int J Molec Sciences, 2020, 2 (8), 3009; 14 str., doi:10.3390/ijms21083009, Epub Apr 24

IF-4,556 MNiSW-140

Characterization of RNP networks of PUM1 and PUM2 post-transcriptional regulators in TCam-2 cells, a human male germ cell model.

Śmiałek MJ, Ilaslan E, Sajek MP, Świercz A, Janecki DM, Kusz-Zamelczyk K, Woźniak T, Kotecki M, Handschuh L, Figlerowicz M, Jaruzelska J

Cells, 2020 Apr 16, 9 (4): 984, doi: 10.3390/cells9040984

IF-4,366 MNiSW-140

Kinesin KIF18A is a novel PUM- regulated target promoting mitotic progression and survival of human male germ cell line.

Śmialek MJ, Kuczyńska B, Ilaslan E, Janecki DM, Sajek MP, Kusz-Zamelczyk K, Jaruzelska J

Journal of Cell Science, 2020, 133 jcs240986, 8 stron, doi: 10.1242/jcs.240986 Epub 2020 Mar 24

IF-4,573 MNiSW-140

Awards

Awarded:
prof. dr hab. n. biol. Jadwiga Jaruzelska
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan

Award of the Faculty of Medical Sciences of the Polish Academy of Sciences

Given by: Faculty of Medical Sciences of the PAS

Prof. Jadwiga Jaruzelska, dr Marcin Piotr Sajek, dr Maciej Jerzy Śmiałek and Ms Erkut Ilaslan were awarded by Medical Division of the Polish Academy of Sciences for 5 articles entitled: “Role of NANOS and PUM proteins in human reproduction and infertility”.

Awarded:
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
dr hab. n. med. Kamila Kusz-Zamelczyk
prof. dr hab. n. biol. Jadwiga Jaruzelska
mgr inż. Damian Janecki

Publication of the year 2019

Given by: Director of the Institute of Human Genetics PAS

Award of the Director of the Institute of Human Genetics of the Polish Academy of Sciences for a review entitled „PUM1 and PUM2 exhibit different modes of regulation for SIAH1 That Involve cooperativity with Nanos paralogues" published in the journal Cellular and Molecular Life Sciences, which awarded the title PUBLICATION OF THE YEAR 2019.

Awarded:
dr hab. n. med. Kamila Kusz-Zamelczyk
mgr Anna Spik
dr n. med. Marcin Sajek
prof. dr hab. n. biol. Jadwiga Jaruzelska

Award from The Polish Society of Genetics

Given by: Polish Society of Genetics

For the best paper published in 2013 in the field of human genetics, describing studies conducted in a Polish laboratory

Awarded: prof. dr hab. n. biol. Jadwiga Jaruzelska

Established Scientist Award (2002)

Given by: European Society of Human Reproduction and Embryology