The department carries out studies into the molecular background of male infertility and the biological properties of stem cells (of myogenic origin) from the perspective of their application in organ regeneration. We apply the tools of systemic biology to the transcriptomic identification of gene expression in dysfunctional male gonads and DNA arrays of infertile individuals to identify novel genes. In the second module, studies of pro-generative properties of stem cells are investigated in clinical trials for regeneration of a) post-infarction heart, b) anal sphincters and c) muscular dystrophies.
Fiedorowicz K, Wargocka-Matuszewska W, Ambrożkiewicz KA, Rugowska A, Cheda Ł, Fiedorowicz M, Zimna A, Drabik M, Borkowski S, Świątkiewicz M, Bogorodzki P, Grieb P, Hamankiewicz P, Kolanowski TJ, Rozwadowska N, Kozłowska U, Klimczak A, Kolasiński J, Rogulski Z, Kurpisz M
Punkty-140Int J Mol Sci (MDPI), 2021 Oct 8; 22 (19):10885, 20 stron, doi: 10.3390/ijms22191088
Molecular imaging of myogenic stem/progenitor cells with [ 18 F]-FHBG PET/CT system in SCID mice model of post-infarction heart.
Wargocka-Matuszewska W, Fiedorowicz K, Rugowska A, Bednarowicz K, Zimna A, Cheda Ł, Hamankiewicz P, Kilian K, Fiedorowicz M, Drabik M, Rozwadowska N, Rogulski Z, Kurpisz M
Budzińska M, Zimna A, Kurpisz M.
Assessment of Immunological Potential of Glial Restricted Progenitor Graft In Vivo—Is Immunosuppression Mandatory?
Kozlowska U, Klimczak A, Bednarowicz KA , Zalewski T, Rozwadowska N, Chojnacka K, Jurga S, Barnea ER and Kurpisz MK.Cells, 2021, 10 (7), e1804, 26 stron, doi.10.3390/cells10071804
Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure.
Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieño-Enríquez MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O’Bryan MK, Conrad DF, Kurpisz M, Tüttelmann F, Yatsenko AN; GEMINI ConsortiumHum Genet, 2021 Aug;140 (8):1169-1182. doi: 10.1007/s00439-021-02287-y. Epub 2021 May 7.
Addition of Popular Exogenous Antioxidant Agent, PBN, to Culture Media May Be an Important Step to Optimization of Myogenic Stem/Progenitor Cell Preparation Protocol.
Nowaczyk M, Malcher A, Zimna A, Łabędź W˛ Kubaszewski Ł, Barczak W , Rubiś B, Rozwadowska N and Kurpisz MAntioxidants (MDPI), 2021, 1 (6), e959, 17 stron, https://doi.org/10.3390/antiox10060959
The Negative Impact of Varicocele on Basic Semen Parameters, Sperm Nuclear DNA Dispersion and Oxidation-Reduction Potential in Semen.
Gill K, Kups M, Harasny P, Machalowski T, Grabowska M, Lukaszuk M, Matuszewski M, Duchnik E, Frączek M, Kurpisz M and Piasecka MInt J Environ Res Public Health (MDPI), 2021, 18 (11): e5957, 16 str, https: / doi.org. 103390.ijerph18115977
Effect of acute isooxic hypercapnia on oxidative activity of systemic neutrophils in endotoxemic rabbits.
Billert H, Bednarek E, Kusz K, Ponichter M, Kurpisz MCent Eur J Immunol 2021; 46 (1): 47-53 https://doi.org/10.5114/ceji.2021.105245
Badanie chromosomów plemnikowych u sześciu nosicieli rzadkich i częstych translokacji robertsonowskich. Publikacja dwujęzyczna (ang. i pol.).
Olszewska M, Wiland E, Wanowska E, Hueluk N, Chernykh VB, Zastavna D, Kurpisz MPostepy Hig Med Dosw, 2021; 75: 199-210; DOI: 10.5604/01.3001.0014.8122
Viability and intracellular nitric oxide generation in the umbilical cord blood CD34+CD133– and CD34+CD133+ cell populations exposed to local anaesthetics.
Kulińska K, Billert H, Sawiński K, Czerniak K, Kurpisz MCentral Eur J Immunol, 2020, 45 (4): 369-376, DOI: https://doi.org/10.5114/ceji.2020.103410
Featured research projects
1. National Science Centre research project 2017/26/D/NZ5/00789
2. National Science Centre research project 2017/25/B/NZ5/01131
3. National Science Centre research project 2015/17/B/NZ2/01157
4. National Science Centre research project 2015/17/D/NZ5/03442
5. National Centre for Research and Development (Applied Research Programme) research project PBS3/A7/27/2015
6. National Centre for Research and Development (STRATEGMED Programme)research project STRATEGMED1/233209/12/NCBR/2015
7. National Centre for Research and Development (STRATEGMED Programme) research project STRATEGMED1/233624/5/NCBR/2014
8. National Science Centre research project 2015/19/B/NZ5/02241
9. National Science Centre research project 2014/15/B/ST4/04946
10. National Science Centre research project 2014/13/B/NZ3/04646
University of Vienna, Vienna, Austria, Cardiac Department, Austria
Freie University, Department of Physics ,Germany
Early Stage Investigator registration scholarship, American Society of Andrology, 46th Annual Conference
Early Stage Investigator registration scholarship
Polish Intelligent Development Award 2020 in the category: Scientist of the future
Analysis of DNA methylation pattern in spermatozoa of infertile men with oligozoospermia, funded by National science Centre, SONATA 2015/17/D/NZ5/03442.
Nomination for the "AMBASSADOR OF INNOVATION"
economic award for thinking ahead, pioneering projects and numerous successes
dr n. med. Marta Olszewska
dr hab. n. med. Monika Frączek
prof. dr hab. n. med. Maciej Kurpisz
Oustanding Paper Award for the best paper published in 2019 in Asian Journal of Andrology
Oustanding Paper Award for the best paper published in 2019 in Asian Journal of Andrology Olszewska M, Barciszewska MZ, Fraczek M, Huleyuk N, Chernykh VB, Zastavna D, Barciszewski J, Kurpisz M:
Global methylation status of sperm DNA in carriers of chromosome structural aberrations.
Asian J Androl, 2017, 19: 117-124. https://dx.doi.org/10.4103/1008-682X.168684
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future.
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: : “Analysis of DNA methylation pattern in spermatozoa of infertile men with oligozoospermia”. The material regarding the nominee is available on website: https://rzeczo.pl/blog/2020/07/08/nieplodnosc-to-tez-epigenetyka/.
Nomination for the Polish Inteligent Develpoment Award 2020
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: ‘Verification of the hypothesis of oxidative stress, apoptosis and immune factor as the mechanisms responsible for the poor semen quality in men exposed to genital heat stress’. The winners of this prestigious award have been for five years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.
Nomination for the Polish Inteligent Development Award 2019
Dr n. med. Agnieszka Malcher has been nominated for the Polish Intelligent Development Award 2019 in the category: Scientist of the future for the project: "Novel causative genetic variants in azoospermia: whole genome analysis and functional in vitro studies." The winners of this prestigious award have been for four years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.
Short-Term Fellowships of European Molecular Biology Organization (EMBO) to implement the project CRISPR/Cas9 system based spermatogenesis impairment in vitro modeling of human male gonad. The research will be conducted in Max Planck Institute for Molecular Genetics in Germany.
For the 27th time, the Foundation for Polish Science awarded START scholarships to the most talented young scientists from all over Poland. Among 100 young researchers was Dr. Agnieszka Zimna from the Department of Reproductive Biology and Stem Cells.
The Ludwik Hirszfeld prize
For his outstanding contribution to development of Immunology in Poland (Warsaw, 8th June, 2017)