The Department of Molecular and Clinical Genetics has a broad range of scientific interests. The Department conducts studies on the genetics of cystic fibrosis, primary ciliary dyskinesia and diseases related to genetically determined defects of motile cilia. Department also investigates the molecular and genetic aspects of hematologic diseases (especially acute T-cell lymphoblastic leukemia), as well as monitoring of the treatment response (so called residual disease). Last, but not least, we conduct research on issues related to the genetic diversity of human populations. In all cases, we are interested not only in broadening of the basic knowledge, but also its practical application.
Department of Molecular and Clinical Genetics
Featured publications
The Thousand Polish Genomes - A Database of Polish Variant Allele Frequencies.
Kaja E, Lejman A, Sielski D, Sypniewski M, Gambin T, Dawidziuk M , Suchocki T, Paweł Golik P, Wojtaszewska M, Mroczek M, Stępień M, Szyda J, Lisiak-Teodorczyk K, Wolbach F, Daria Kołodziejska D,
Ferdyn K, Dąbrowski M, Woźna A, ̇Żytkiewicz M, Bodora-Troińska A, Elikowski W, Król ZJ, Zaczyński A, Pawlak A, Robert Gil R, Wierzba W, Dobosz P, Zawadzka K, Zawadzki P and Sztromwasser P
Int. J. Mol. Sci (MDPI), 2022, 23 (9), 4532; 17 str, doi./10.3390/ijms23094532IF-5,924 MNiSW-140
CRISPRi for specific and miRNAs with high sequence homology.
Drobna-Śledzińska M, Maćkowska-Maślak N, Jaksik R, Dąbek P, Witt M, Dawidowska M
Scientific Reports, 2022, 12: 6237, doi: 10.1038/s41598-022-10336-3IF-4,380 MNiSW-140
Editorial: Perspectives for Primary Ciliary Dyskinesia. This article belongs to the Special Issue on “Primary Ciliary Dyskinesis: Genetics, Molecular Mechanisms Diagnostic and Therapeutic Perspectives”,
Bukowy-Bieryłło Z, Witt M, Ziętkiewicz E
Int J Mol Sci (MDPI) 2022, 23 (8), 4122; 4 strony, doi.org/10.3390/ijms23084122IF-5,924 MNiSW-140
Special Issue on “Primary Ciliary Dyskinesia: Genetics, Molecular Mechanisms, Diagnostic and Therapeutic Perspectives.
Witt M, Ziętkiewicz E, Bukowy-Bieryllo Z (guest editors)
Int J Molec Sci (MDPI), closed Dec 30, published 2022IF-5,923 MNiSW-80
Genetic testing—whether to allow complete freedom? Direct to consumer tests versus genetic tests for medical purposes.
Madej M, Sąsiadek M, Witt M
J Appl Genetics, 2022 Febr , 63 (1): 119-126 Epub 2021 Nov 12, doi.org/10.1007/s13353-021-00670-zIF-3,240 MNiSW-100
In vitro differentiation of ciliated cells in ALI-cultured human airway epithelium - The framework for functional studies on airway differentiation in ciliopathies.
Bukowy-Bieryłło Z, Daca-Roszak P, Jurczak J, Przystałowska-Macioła H, Jaksik R, Witt M, Ziętkiewicz E
European Journal of Cell Biology, 101, 2022; 151189, doi.org/10.1016/j.ejcb.2021.151189IF-4,492 MNiSW-100
Validation of HER2 status in whole genome sequencing data of breast cancers with the ploidy-corrected copy number approach.
Wojtaszewska M, Stępień R, Woźna A, Piernik M, Sztromwasser P, Dąbrowski M, Gniot M, Szymański S, Socha M, Kasprzak P, Matkowski R, Zawadzki P
Molecular Diagnosis and Therapy, 2022, 26 (1): 105-116, doi: 10.1007/s40291-021-00571-1, 12 str.IF-4,074 MNiSW-70
Innowacje w diagnostyce nowotworów: genomika, sekwencjonowanie nowej generacji i sztuczna inteligencja.
Wojtaszewska M, Dąbrowski M
W: Nowoczesna Diagnostyka w Onkologii, 2021, PZWL Wydawnictwo Lekarskie sp. z o.o., ISBN: 978-83-200-6474-2,MNiSW-20
RNA-seq library preparation for comprehensive transcriptome analysis in cancer cells.
Jaksik R, Drobna-Śledzińska M and Dawidowska M
Genomics, 2021 Nov, 11 (6): 4149-62, Epub Nov 3, doi.10.1016/j.ygeno.2021.10.018IF-5,736 MNiSW-100
Inheritance vs. infectibity as a mechanism of malady and death of Frederic Chopin.
Witt M, Dobosz T
J Appl Genet, 2021 Dec, 62 (4): 607-611, Epub Aug 4. doi: 10.1007/s13353-021-00651-2IF-3,240 MNiSW-100
All publications
Featured research projects
1. STRATEGMED research project
Personalization of childhood acute lymphoblastic leukemia treatment in Poland
(PersonALL)
realized within the STRATEGMED-III program „Prevention and treatment of civilization diseases”
Project consortium members:
Silesian Medical University, Katowice
Institute of Innovative Techniques EMAG in Katowice
Medical University of Lodz
Institute of Human Genetics PAS in Poznan
Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun
Medical University of Lublin
Medical University of Wroclaw
Medical University of Poznan
Warsaw Medical University
Medical University of Bialystok
Gdansk Medical University
Pomeranian Medical University in Szczecin
NET-O-LOGY company
2. NCN research project 2016/20/T/NZ4/00525
Drug-stimulated premature termination codon readthrough in selected genes involved in primary ciliary dyskinesia (PCD)
(2016-2018)
3. NCN research project 2014/13/B/NZ2/03858
Whole exome sequencing in Polish population of patients – search for the genetic basis of primary ciliary dyskinesia, PCD
(2015-2018)
4. NCN research project 2014/15/B/NZ2/03394
Next-generation sequencing of miRNA transcriptome and functional in vitro study: towards unravelling pathomechanisms and heterogeneity of pediatric T-cell acute lymphoblastic leukemia (T-ALL)
(2015-2018)
5. NCN research project 2013/11/N/NZ5/03730
Genetics of pediatric T-cell acute lymphoblastic leukemia
(2014-2017)
6. NCN research project 2013/09/D/NZ4/01692
The influence of external factors on the dynamics of the respiratory epithelium differentiation in the context of the use of the different in vitro ciliogenesis regimens in studies on primary ciliary dyskinesia
(2014-2017)
7. The research project of the European Union COST BM1407
International project financed from EU funds: “Translational research in primary ciliary dyskinesia – bench, bedside, and population perspectives (BEAT-PCD)”
http://www.cost.eu/COST_Actions/bmbs/BM1407
(2015-2019)
8. The research project of the European Union COST IS1303
International project financed from EU funds: “Citizen’s Health through public- private Initiatives: Public health, Market and Ethical perspectives’ CHIP-ME
http://www.cost.eu/COST_Actions/isch/IS1303
(2013-2017)
9. The research project of the European Union FP7 305404
International project financed from EU funds (FP7): „Better Experimental Screening and Treatment for Primary Ciliary Dyskinesia” BESTCILIA
(2013-2016)
10. Projekt badawczy Ministerstwa Nauki nr OR00 0027 12
Multi-center R & D project “Identification of genetic markers useful for identifying human populations (AriaDNA)”
(2011-2014)
Collaborations
Awards
Awarded:
mgr inż. Monika Drobna-Śledzińska
Scholarship
Given by: Director IBCH PAS
Scholarship 2020/21
Awarded:
mgr Alicja Rabiasz
Polish Intelligent Development Award 2020 in the category: Scientist of the future
Given by: Inteligent Development Center
Poszukiwanie nowych genów zaangażowanych w patogenezę pierwotnej dyskinezy rzęsek: analiza funkcjonalna genów kandydatów metodą interferencji RNA.
Awarded:
dr hab. n. med. Małgorzata Dawidowska
Prime Minister's award
Given by: Prime Minister
Prime Minister's award in the category of highly valued scientific achievements that were the basis for awarding the habilitation
Awarded:
mgr Alicja Rabiasz
Nomination for the Polish Intelligent Development Award 2020
Given by: Polish Intelligent Development
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: : “In search for new genes involved in primary ciliary dyskinesia pathogenesis: functional screening of candidate genes using RNA interference"
Awarded:
mgr inż. Monika Drobna-Śledzińska
Scholarship from the City of Poznań for young researchers
Given by: Scholarship of City of Poznań
Monika Drobna, MSc. – PhD student from the Department of Molecular and Clinical Genetics has received a scholarship from the City of Poznań for young researchers for outstanding scientific activity and scientific achievements in the field of molecular research including microRNA, which are the basis of childhood T-cell acute lymphoblastic leukemia.
Awarded:
mgr inż. Monika Drobna-Śledzińska
Honorable mention
Given by: Poznań branch of the Polish Academy of Sciences
Monika Drobna, MSc, was granted a honorable mention in the contest for the best original paper published in 2018, with a PhD student as the leading author, organized by the Poznań branch of the Polish Academy of Sciences. The work entitled „Identification of endogenous control miRNAs for RT-qPCR in T-cell acute lymphoblastic leukemia” [Drobna M, Szarzyńska-Zawadzka B, Daca-Roszak P, Kosmalska M, Jaksis R, Witt M, Dawidowska M; Int J Mol Sci, 2018, 19 (10): e2858].
Awarded:
dr n. med. Bronisława Szarzyńska-Zawadzka
The Kosciuszko Foundation Grant
Given by: Kosciuszko Foundation
Bronisława Szarzyńska-Zawadzka has been awarded a Kosciuszko Foundation Grant for the academic year 2019/2020, to visit University of New Mexico, NM, US. During the 3-month visit at University of New Mexico in Albuquerque Bronisława Szarzyńska-Zawadzka will study tumor suppressor function of RNA-binding protein QKI-5 in T-cell lineage acute lymphoblastic leukemia.
The Kosciuszko Foundation promotes closer ties between Poland and the United States through educational, scientific and cultural exchanges. The Kosciuszko Foundation annually awards a number of Fellowships/Grants to Poles for advanced study, research, and/or teaching at universities and other institutions of higher learning in the United States.
Awarded:
dr n. med. Bronisława Szarzyńska-Zawadzka
Award for the best review publication in 2018
Given by: Director of the Institute of Human Genetics PAS
the best review publication in 2018 entitled: "T-cell acute lymphoblastic leukemia from miRNA perspective” published in the prestigious journal Blood Reviews
Awarded:
mgr inż. Monika Drobna-Śledzińska
Award for the best review publication in 2018
Given by: Director of the Institute of Human Genetics PAS
the best review publication in 2018 entitled: "T-cell acute lymphoblastic leukemia from miRNA perspective" published in the prestigious journal Blood Reviews
Awarded:
dr hab. n. med. Małgorzata Dawidowska
Award for the best review publication in 2018
Given by: Director of the Institute of Human Genetics PAS
the best review publication in 2018 entitled: "T-cell acute lymphoblastic leukemia from miRNA perspective" published in the prestigious journal Blood Reviews