The Department of Molecular and Clinical Genetics has a broad range of scientific interests. The Department conducts studies on the genetics of cystic fibrosis, primary ciliary dyskinesia and diseases related to genetically determined defects of motile cilia. Department also investigates the molecular and genetic aspects of hematologic diseases (especially acute T-cell lymphoblastic leukemia), as well as monitoring of the treatment response (so called residual disease). Last, but not least, we conduct research on issues related to the genetic diversity of human populations. In all cases, we are interested not only in broadening of the basic knowledge, but also its practical application.
The hero of American and Polish nations: a molecular look at Thaddeus Kosciuszko’s cause of death suggests a contribution of endocarditis caused by Cutibacterium acnes infection.
Witt M, Tokarski M, Ziętkiewicz E, Lebioda A, Szczypek M, Falkowski W, Mrozowski P, Kulak T, Sobieszczańska M, Mrugalska-Banaszak M, Jurek T, Dobosz TMicrob Cell Fact. 2022 Nov 23;21(1):245. doi: 10.1186/s12934-022-01970-7. PMID: 36419091
Genetic diversity in Kashubs: the regional increase in the frequency of several disease-causing variants.
Jankowski M, Daca‑Roszak P, Obracht‑Prondzyński C, Płoski R, Lipska‑Ziętkiewicz BS, Ziętkiewicz EJ Applied Genetics, 2022 Dec, 63 (4): 691-702, https://doi.org/10.1007/s13353-022-00713-z Epub 2022 Aug 15
Male Infertility Coexists with Decreased Sperm Genomic Integrity and Oxidative Stress in Semen Irrespective of Leukocytospermia
Gill K, Machalowski T, Harasny P, Kups M, Grabowska M, Duchnik E, Sipak O, Frączek M, Kurpisz M, Kurzawa R, Piasecka MAntioxidants (MDPI), 2022, 11 (10): 1987, 18 stron, https://doi.org/10.3390/antiox11101987
Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T-ALL: focus on miR-363-3p and promoter methylation
Drobna-Śledzińska M, Maćkowska-Maślak N, Jaksik R, Kosmalska M, Szarzyńska B, Lejman M, Sędek Ł, Szczepański T, Taghon T, Van Vlierberghe P, Witt M, Dawidowska
M.Genes Chromosomes Cancer, 2022 Dec, 61 (12): 720-733, doi: 10.1002/gcc.23085. Epub Jul 2
Small RNA-Seq Reveals Similar miRNA Transcriptome in Children and Young Adults with T-ALL and Indicates miR-143-3p as Novel Candidate Tumor Suppressor in This Leukemia
Dawidowska M, Maćkowska-Maślak N, Drobna-Śledzińska M, Kosmalska M, Jaksik R, Szymczak D, Jarmuż-Szymczak M, Sadowska-Klasa A, Wojtaszewska M, Sędek Ł, Wróbel T, Zaucha J.M, Szczepański T, Lewandowski K, Giebel S, Witt M
Grabowska M, Kuczyński K, Piwecka M, Rabiasz A, Zemła J, Głodowicz P, Wawrzyniak D, Lekka M, Rolle KJ Cell Mol Med, 2022 Jul, 26 (14): 3913-3930, Epub Jun 15. doi: 10.1111/jcmm.17428
Kaja E, Lejman A, Sielski D, Sypniewski M, Gambin T, Dawidziuk M , Suchocki T, Paweł Golik P, Wojtaszewska M, Mroczek M, Stępień M, Szyda J, Lisiak-Teodorczyk K, Wolbach F, Daria Kołodziejska D,
Ferdyn K, Dąbrowski M, Woźna A, ̇Żytkiewicz M, Bodora-Troińska A, Elikowski W, Król ZJ, Zaczyński A, Pawlak A, Robert Gil R, Wierzba W, Dobosz P, Zawadzka K, Zawadzki P and Sztromwasser PInt. J. Mol. Sci (MDPI), 2022, 23 (9), 4532; 17 str, doi./10.3390/ijms23094532
Drobna-Śledzińska M, Maćkowska-Maślak N, Jaksik R, Dąbek P, Witt M, Dawidowska MScientific Reports, 2022, 12: 6237, doi: 10.1038/s41598-022-10336-3
Editorial: Perspectives for Primary Ciliary Dyskinesia. This article belongs to the Special Issue on “Primary Ciliary Dyskinesis: Genetics, Molecular Mechanisms Diagnostic and Therapeutic Perspectives”,
Bukowy-Bieryłło Z, Witt M, Ziętkiewicz EInt J Mol Sci (MDPI) 2022, 23 (8), 4122; 4 strony, doi.org/10.3390/ijms23084122
Special Issue on “Primary Ciliary Dyskinesia: Genetics, Molecular Mechanisms, Diagnostic and Therapeutic Perspectives.
Witt M, Ziętkiewicz E, Bukowy-Bieryllo Z (guest editors)Int J Molec Sci (MDPI), closed Dec 30, published 2022
Featured research projects
1. STRATEGMED research project
Personalization of childhood acute lymphoblastic leukemia treatment in Poland
realized within the STRATEGMED-III program „Prevention and treatment of civilization diseases”
Project consortium members:
Silesian Medical University, Katowice
Institute of Innovative Techniques EMAG in Katowice
Medical University of Lodz
Institute of Human Genetics PAS in Poznan
Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun
Medical University of Lublin
Medical University of Wroclaw
Medical University of Poznan
Warsaw Medical University
Medical University of Bialystok
Gdansk Medical University
Pomeranian Medical University in Szczecin
2. NCN research project 2016/20/T/NZ4/00525
3. NCN research project 2014/13/B/NZ2/03858
4. NCN research project 2014/15/B/NZ2/03394
5. NCN research project 2013/11/N/NZ5/03730
6. NCN research project 2013/09/D/NZ4/01692
7. The research project of the European Union COST BM1407
International project financed from EU funds: “Translational research in primary ciliary dyskinesia – bench, bedside, and population perspectives (BEAT-PCD)”
8. The research project of the European Union COST IS1303
International project financed from EU funds: “Citizen’s Health through public- private Initiatives: Public health, Market and Ethical perspectives’ CHIP-ME
9. The research project of the European Union FP7 305404
International project financed from EU funds (FP7): „Better Experimental Screening and Treatment for Primary Ciliary Dyskinesia” BESTCILIA
10. Projekt badawczy Ministerstwa Nauki nr OR00 0027 12
Fellowship (EMBO Scientific Exchange Grant)
to implement the project “ The use of mRNA therapy to restore ciliary function in zebrafish with knockout of CCDC39, the known primary ciliary dyskinesia (PCD) gene”.
for the best posters presented on the Human Genetics session: Alicja Rabiasz, Monika Drobna-Śledzińska, Natalia Maćkowska- Maślak, Ewa Ziętkiewicz - POLR2K as a passenger gene mutated together with SPAG1, the known primary ciliary dyskinesia (PCD) gene.
for the best posters presented on the Human Genetics session: Joanna Jurczak, Zuzanna Bukowy-Bieryłło, Hanna Przystałowska-Macioła, Patrycja Daca-Roszak, Roman Jaksik, Michał Witt, Ewa Ziętkiewicz - Functional studies on in vitro differentiation of airway epithelium in ALI culture as a tool for modeling ciliopathies.
Polish Intelligent Development Award 2020 in the category: Scientist of the future
Poszukiwanie nowych genów zaangażowanych w patogenezę pierwotnej dyskinezy rzęsek: analiza funkcjonalna genów kandydatów metodą interferencji RNA.
Prime Minister's award
Prime Minister's award in the category of highly valued scientific achievements that were the basis for awarding the habilitation
Nomination for the Polish Intelligent Development Award 2020
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: : “In search for new genes involved in primary ciliary dyskinesia pathogenesis: functional screening of candidate genes using RNA interference"
Scholarship from the City of Poznań for young researchers
Monika Drobna, MSc. – PhD student from the Department of Molecular and Clinical Genetics has received a scholarship from the City of Poznań for young researchers for outstanding scientific activity and scientific achievements in the field of molecular research including microRNA, which are the basis of childhood T-cell acute lymphoblastic leukemia.
Monika Drobna, MSc, was granted a honorable mention in the contest for the best original paper published in 2018, with a PhD student as the leading author, organized by the Poznań branch of the Polish Academy of Sciences. The work entitled „Identification of endogenous control miRNAs for RT-qPCR in T-cell acute lymphoblastic leukemia” [Drobna M, Szarzyńska-Zawadzka B, Daca-Roszak P, Kosmalska M, Jaksis R, Witt M, Dawidowska M; Int J Mol Sci, 2018, 19 (10): e2858].
The Kosciuszko Foundation Grant
Bronisława Szarzyńska-Zawadzka has been awarded a Kosciuszko Foundation Grant for the academic year 2019/2020, to visit University of New Mexico, NM, US. During the 3-month visit at University of New Mexico in Albuquerque Bronisława Szarzyńska-Zawadzka will study tumor suppressor function of RNA-binding protein QKI-5 in T-cell lineage acute lymphoblastic leukemia.
The Kosciuszko Foundation promotes closer ties between Poland and the United States through educational, scientific and cultural exchanges. The Kosciuszko Foundation annually awards a number of Fellowships/Grants to Poles for advanced study, research, and/or teaching at universities and other institutions of higher learning in the United States.