Project title: Development of an innovative therapy for gut dysbiosis — a unique combination of microbiota, its metabolites, and adaptogens.
Implementation period: 01.01.2025 – 31.03.2026
EU funding: PLN 3,461,691.85
Objective: To develop an innovative yet universal oral therapeutic blend that stimulates the healing of dysbiosis and restores homeostasis. Existing clinical trials indicate a significant role of specific plant-derived substances and bacterial metabolic products, particularly short-chain fatty acids (SCFAs), in the treatment of inflammatory bowel diseases. However, these compounds have not been sufficiently characterized in terms of recommended doses and treatment protocols, nor have they been tested in combinations that could be administered to patients to effectively stimulate the colonization of the gut mucosa by commensal microbes. The unique character of the therapy will lie in supplementing the gut microenvironment with the dose and composition necessary for the optimal growth of probiotic bacteria.
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Project title: CARDIOPRINT – Cardiac Advanced Regenerative Design Integrating Organic PRINTing
Implementation period: 01.01.2025 – 31.03.2026
EU funding: PLN 7,326,856.66
Objective: To prepare physiologically and anatomically compatible 3D cardiac tissue constructs using bioprinting for regenerative medicine purposes. The constructs will consist of heart cells (cardiomyocytes, fibroblasts, vascular cells) derived from human-induced pluripotent stem cells (hiPSCs) and components of the cardiac extracellular matrix, enabling biomimicry of cardiac tissue properties. The project will focus on: (1) reproducing the anatomy of cardiac tissue within the construct, (2) ensuring its contractile functionality, and (3) physiological compatibility with the human heart.
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Project title: Integrative multi-omic platform based on high-resolution mass spectrometry for metabolome and microbiome research with machine learning integration.
Implementation period: 01.01.2025 – 31.12.2026
EU funding: PLN 6,730,424.66
Objective: To create an innovative high-throughput bioanalytical platform and develop omics techniques in biomedical, biological, and agricultural research, particularly focused on the microbiota of humans, plants, and the environment.
Project implemented in consortium with the Institute of Plant Genetics of the Polish Academy of Sciences.
Project title: ERASMUS+
Implementation period: 2024–2026
EU funding: EUR 38,145
Objective: Supporting international cooperation of universities and research institutes through conducting part of studies and internships abroad, promoting staff mobility, and providing opportunities for participation in projects in cooperation with foreign partners.
Project title: ERDERA – European Rare Diseases Research Alliance
Implementation period: 2024–2031
EU funding: EUR 26,250
Objective: Developing a comprehensive database, knowledge base, and innovative research services in the field of advanced therapies, funding new research projects, offering training, and translating research results into specific solutions for patients.
ERDERA is a partnership bringing together over 170 institutions from 37 countries, including leading research institutes, patient organizations, European research infrastructures, pharmaceutical and technology companies, public funding agencies, public and private charities, regulatory authorities, health protection bodies, hospitals, universities, and medical associations.
Project title: SUSTAINIGHT Horizon Europe/Researchers’ Night 2023, project no. 101162504
Implementation period: 2024–2026
EU funding: EUR 13,860
Objective: Innovative promotional activities by presenting to the public in an engaging way what scientists do. Promoting science by inviting the public into research laboratories, participating in experiments, workshops, and educational games.
Project implemented in cooperation with: Poznań University of Technology, Adam Mickiewicz University, Poznań University of Economics, Poznań University of Life Sciences, Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań Supercomputing and Networking Center (PCSS).
Project title: On the road to excellence in unravelling the (epi)genetic landscape of hematologic neoplasms – NEXT_LEVEL
Implementation period: 2021–2023
Objective: To enhance the scientific excellence of the partner institutions, with particular emphasis on the Institute of Human Genetics of the Polish Academy of Sciences in the field of hemato-oncology.
EU funding: EUR 899,525
Project implemented in consortium with: University of Groningen, University of Göttingen, University of Ulm.
Project website.
The project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 952304.
Partnership project of the Wielkopolska Voivodeship self-government entitled: Activities related to the prevention/mitigation of the effects of the COVID-19 epidemic under the Wielkopolska Regional Operational Programme 2014–2020.
Implementation period: 2020–2021
EU funding: PLN 1,079,764
Objective: To increase the safety of medical services provided by healthcare entities and other organizations in the Wielkopolska region engaged in combating the COVID-19 epidemic.
Project description: The Institute of Human Genetics of the Polish Academy of Sciences implements a task related to the purchase of equipment and materials necessary to combat the COVID-19 epidemic.
Project title: PROM. International scholarship exchange of doctoral students and academic staff
Implementation period: 2019–2021
Objective: To create a financial support mechanism for scholarship exchanges aimed at doctoral students and academic staff. The program enables participation in short-term educational activities (lasting from 5 to 30 days) aimed at improving competences and qualifications. The project, implemented under the PROM Programme, contributes to improving the accessibility of international education programs and increases the mobility of staff both in terms of Polish university and research institution representatives going abroad and scholarship recipients coming to Poland, including those from outside the EU.
EU funding: PLN 388,720
Project website.
Project title: Development of the internationalization of the Institute of Human Genetics of the Polish Academy of Sciences by supporting institutional capacity to serve foreign doctoral students and researchers (Acronym: 2INTEGRATe)
Implementation period: 2020–2021
Objective: To strengthen the institutional capacity of the Institute of Human Genetics of the Polish Academy of Sciences by implementing training activities for IGC staff and introducing organizational changes.
EU funding: PLN 145,048
Project website.
Project title: Liquid biopsy – a tool for detecting “cancer fingerprints” in the peripheral blood of patients with head and neck cancers
Implementation period: 2018–2021
Objective: To develop a product: a diagnostic and predictive test for detecting traces of cancer genetic material in the peripheral blood (“CancerFingerprints”) of patients with head and neck squamous cell carcinomas (HNSCC).
Outcome of the project: A new medical product, previously unknown on the Polish and international markets. The developed product will find wide application in the economy as a diagnostic tool and as a companion to HNSCC therapy, as well as an element of routine periodic examinations.
EU funding: PLN 4,143,012.50
The project is implemented by a consortium comprising:
Poznań University of Medical Sciences
Heliodor Święcicki Clinical Hospital of the Poznań University of Medical Sciences
Institute of Human Genetics of the Polish Academy of Sciences
DNA Research Center Sp. z o.o.
Project title: Functional analysis of the IGH gene regulatory region in B-cell non-Hodgkin lymphomas under the FIRST-TEAM programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund.
Implementation period: 2019–2021
EU funding: PLN 1,952,960
Project description: A characteristic feature of B-cell non-Hodgkin lymphomas is the translocation of oncogenes (e.g., MYC, BCL2) to the regulatory region of the immunoglobulin heavy chain (IGH) gene. The proliferation of many lymphomas depends on the expression of these oncogenes and the signaling pathways of the B-cell receptor (BCR), which is expressed from the second, functional IGH allele. Regulatory elements in the IGH gene have been studied in the development of normal B cells, but their role in cancer cells remains undefined. The project aims to identify and characterize functional elements in the IGH regulatory region and enhancer RNAs (eRNAs) necessary for the growth of B-cell lymphoma cells. Modern methods such as CRISPR/Cas9 screening, GRO-seq, and chromatin immunoprecipitation will be used. The project is carried out in collaboration with scientists from the Netherlands and the USA.