- Timetable of the lecture “Epigenetics of development” – winter semester 2024/2025
- SYLLABUS of the lecture “Epigenetics of development” – winter semester 2024/2025
Lecture Epigenetics of development
winter semester 2024/2025
(This lecture is obligatory)
Lectures will be held on Wednesdays in hybrid mode.
| Data | Temat |
| 16 October 9:00-12:00 |
Introduction to epigenetics 1h
(prof. dr hab. Jadwiga Jaruzelska) Biochemistry of nucleotide DNA modification processes, including enzymes responsible for establishment (writers), recognition (readers) and removal (erasures) of such epigenetic marks 2h (prof. dr hab. Jan Barciszewski) |
| 24 October (Thursday) 10:00-12:00 |
Chromatin carriers of epigenetic modifications including methodologies used in studying such events 2h
dr Weronika Sura |
| 30 October
9:00-11:00 |
microRNA in myogenesis 2h
prof. dr hab. Krzysztof Sobczak |
| 6 November 9:00 – 11:00 |
Long noncoding RNAs (lncRNAs) and methodologies in studying their functionality 2h
dr hab. Agnieszka Dzikiewicz-Krawczyk |
| 13 November 9:00 – 11:00 |
Circular RNAs (circRNAs) – functional significance and methodologies for their identification and function 2h
dr hab. Monika Piwecka |
| 20 November 9:00 – 10:00 |
PIWI-interacting RNAs (piRNAs) – functions in genome stability and transmission of epigenetic information 1h
dr hab. Monika Piwecka |
| 27 November 9:00 -11:00 |
Beyond the genetic code: the histone and RNA Polymerase II codes in the transcription cycle 2h
dr hab. Kinga Kamieniarz-Gdula |
| 4 December 9:00 -11:00 |
Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modificationsInteraction between environment and epigenetic marks 2h
prof. dr hab. Jadwiga Jaruzelska |
| 18 December 9:00 -12:00 |
Erasure and reappearance of epigenetic marks in the human life cycleEpigenetics and human diseases 3h
prof. dr hab. Jadwiga Jaruzelska |
SYLLABUS
Winter semester 2024/2025
| Course | Epigenetics of development |
| Host Institution | Institute of Human GeneticsPolish Academy of Sciences
Strzeszyńska Street, 32 |
| Language | English |
| The expected effects of teaching in terms of: knowledge, skills and social qualifications | Ph. D. student is supposed to:
1.Gain knowledge in several aspects of epigenetics and significance in human health and disease. In particular, the following specific topics will be elaborated: – what epigenetics is all about – types of epigenetic nucleotide modifications present in human DNA – enzymes and other proteins involved in epigenetic mark setup, maintenance and erasure – chromatin epigenetics mark carriers – functional significance microRNAs and other small noncoding RNAs in epigenetic regulation – circular RNAs: origin and functional significance including methodologies for their identification and function – function of piRNAs in genome stability and transmission of epigenetic information – role of sperm RNA in epigenetic inheritance – epigenetic life cycle – influence of environmental factors on epigenetic pattern – epigenetics and human diseases 2. Get familiar with new directions in the field of studying epigenetics in human development and disease 3. Learn how to formulate scientific questions related to epigenetics in human development and health |
| Type of course | Obligatory |
| Semester/year | winter semester 2024/2025 |
| First name/family name of the person responsible for the course | prof. dr hab. Jadwiga Jaruzelska |
| First name/family name of the person responsible for the exam | prof. dr hab. Jadwiga Jaruzelska |
| Format | Lecture will be held in English with usage of audio-visual equipment. |
| Basic and additional requirements | Skills in English |
| Number of ECTSs | 3 ECTS |
| ECTSs summary | 1 ECTS corresponds to 25-30 hours of personal studies focused on broadening knowledge based on suggested bibliography (vide bibliography list below). |
| Method of teaching | Lectures will be held using power point presentation and a multimedia projector |
| Method of evaluation | written exam |
| Prerequisite for passing | Positive score at the exam |
| Topics | – DNA nucleotide epigenetic marks
– enzymes involved in writing, maintenance and erasure of nucleotide epigenetic marks – chromatin carriers of epigenetic marks – long noncoding RNAs – microRNAs and other short noncoding RNAs – circular RNAs – piRNAs – epigenetic inheritance through sperm RNAs – dynamics of epigenetic marks in the human life cycle – epigenetics and human disease |
| Additional material | Presentation of each lecture in PDF format and R scripts |
| Bibliography | Will be suggested later |