Kamila Kusz-Zamelczyk PhD is the Faculty of Biology at the Adam Mickiewicz University and Doctoral Studies at the Institute of Bioorganic Chemistry PAS graduate. She obtained the habilitation degree at the Institute of Human Genetics PAS. Her research focuses on genetics of sex determination and development. In particular she investigates the role of RNA binding proteins – NANOS and PUMILIO in the development of human germ cells.
dr hab. n. med. Kamila Kusz-Zamelczyk
Publications
Mutations in STARD8 (DLC3) may cause 46,XY gonadal dysgenesis.
Sirokha D, Rayevsky A, Gorodna O, Kalynovskyi V, Zelinska N, Samson O, Kwiatkowska K, Nef S, Jaruzelska J, Kusz-Zamelczyk K, Livshits L
Sexual Development, 2023, 14 (4-6): 181-189, doi: 10.1159/000537877, Epub 2024 Mar 6IF-2.4 MNiSW-100
Genetyczne podstawy kształtowania się płci biologicznej
Kusz-Zamelczyk K
W: „O kształtowaniu się płci człowieka. Konferencja popularno-naukowa” Wydane pod red. B. Gawrońskiej-Kozak i J. Wiśniewskiej, Wyd. Oddział PAN w Olsztynie, 2022, ISBN 978-83-942794-6-2MNiSW-20
Emerging Roles of NANOS RNA-Binding Proteins in Cancer.
Ilaslan E, Sajek MP, Jaruzelska J, Kusz-Zamelczyk K
Int J Mol Sci (MDPI), 2022 Aug 20; 23 (16): 9408, 12 str,doi: 10.3390/ijms23169408.IF-6,208 MNiSW-140
Distinct Roles of NANOS1 and NANOS3 in the Cell Cycle and NANOS3‐PUM1‐FOXM1 Axis to Control G2/M Phase in A Human Primordial Germ Cell Model.
Ilaslan E, Kwiatkowska K, Śmialek MJ, Sajek MP, Lemańska Ż, Alla M, Janecki DM, Jaruzelska J, Kusz‐Zamelczyk K
Int J Molec Sci (MDPI), 2022, 23 (12): 6592, 19 str, https://doi.org/10.3390/ijms23126592IF-5,924 MNiSW-140
Special Issue on “Sex Determination Mechanisms and Disease”
Jaruzelska J, Kusz-Zamelczyk K, Bertelloni S (guest editors)
Int J Molec Sci (MDPI), closed Dec 30, published 2022, 3 articlesIF-5,923 MNiSW-80
A Novel WT1 Mutation Identified in a 46,XX Testicular/Ovotesticular DSD Patient Results in the Retention of Intron 9.
Sirokha D, Gorodna O,Vitrenko Y, Zelinska N, Ploski R, Nef S, Jaruzelska J, Kusz-Zamelczyk K and Ludmila Livshits L
Biology (MDPI), 2021, 10 (12), 1248,13 str, doi: 10.3390/biology10121248IF-5,079 MNiSW-100
The FKBP4 gene, encoding a regulator of the androgen receptor signaling pathway, is a novel candidate gene for androgen insensitivity syndrome.
Ilaslan E, Markosyan R, Sproll P, Stevenson BJ, Sajek M, Sajek MP, Hayrapetyan H, Sarkisian T, Livshits L, Nef S, Jaruzelska J, Kusz-Zamelczyk K
Internatl J Molecular Sciences, 2020 Nov-1, e8403,11 str, doi:10.3390/ijms21218403IF-4,556 MNiSW-140
Human NANOS1 Represses Apoptosis by Downregulating Pro-Apoptotic Genes in the Male Germ Cell Line.
Janecki DM, Ilaslan E, Śmiałek MJ, Sajek MP, Kotecki M, Ginter-Matuszewska B, Krainski P, Jaruzelska J, Kusz-Zamelczyk K
Int J Molec Sciences, 2020, 2 (8), 3009; 14 str., doi:10.3390/ijms21083009, Epub Apr 24IF-4,556 MNiSW-140
Characterization of RNP networks of PUM1 and PUM2 post-transcriptional regulators in TCam-2 cells, a human male germ cell model.
Śmiałek MJ, Ilaslan E, Sajek MP, Świercz A, Janecki DM, Kusz-Zamelczyk K, Woźniak T, Kotecki M, Handschuh L, Figlerowicz M, Jaruzelska J
Cells, 2020 Apr 16, 9 (4): 984, doi: 10.3390/cells9040984IF-4,366 MNiSW-140
Kinesin KIF18A is a novel PUM- regulated target promoting mitotic progression and survival of human male germ cell line.
Śmialek MJ, Kuczyńska B, Ilaslan E, Janecki DM, Sajek MP, Kusz-Zamelczyk K, Jaruzelska J
Journal of Cell Science, 2020, 133 jcs240986, 8 stron, doi: 10.1242/jcs.240986 Epub 2020 Mar 24IF-4,573 MNiSW-140
All publications
Events
2008 Where:
Berlin
XX International Congress of Genetics, “The expression patterns of the NANOS2 and NANOS3 genes and significance in the human reproduction” K.Kusz, L.Tomczyk, A.Spik, A.Latos-Bieleńska, P.Jędrzejczak, L.Pawelczyk, J.Jaruzelska, oral communication “NANOS1 and PUMILIO2 conserved fertility proteins form complexes with GEMIN3 – A factor of microRNA biogenesis, in the human male germ cells” B.Ginter-Matuszewska, K.Kusz, A.Spik, A.Rembiszewska, J.Kupriańczyk, J.Jaruzelska
2005 Where:
Salt Lake City
55th Annual Meeting of American Society of Human Genetics “Sequence variants of the NANOS3 gene are associated with testis atrophy and a pure sterility phenotype in men” K.Kusz, L.Tomczyk, J.Bierła, A.Latos-Bieleńska, P.Jędrzejczak, L.Pawelczyk and J.Jaruzelska
2004 Where:
Toronto
54th Annual Meeting of American Society of Human Genetics, Toronto, oral communication: „Dominant mutations in the human homolouge of the Drosophila Nanos morphogen cause a lack of germ cells and pure sterility phenotype in men” K.Kusz, A.Spik, A.Latos-Bieleńska, M.Kotecki, J.Bierła, P.Jędrzejczak, L.Pawelczyk, J.Jaruzelska
Awards
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
dr hab. n. med. Kamila Kusz-Zamelczyk
prof. dr hab. n. biol. Jadwiga Jaruzelska
mgr inż. Damian Janecki
Publication of the year 2019
Award of the Director of the Institute of Human Genetics of the Polish Academy of Sciences for a review entitled „PUM1 and PUM2 exhibit different modes of regulation for SIAH1 That Involve cooperativity with Nanos paralogues" published in the journal Cellular and Molecular Life Sciences, which awarded the title PUBLICATION OF THE YEAR 2019.
Nomination for the Polish Inteligent Development Award 2019
Dr hab. Kamila Kusz-Zamelczyk has been nominated for the Polish Intelligent Development Award 2019 in the category: Scientist of the future for the project: " Badania potencjalnej roli białek NANOS w kontroli translacji funkcjonalnie powiązanych ze sobą mRNA, w ludzkich komórkach linii płciowej: poszukiwanie mechanizmu potranskrypcyjnych regulonów u ssaków." The winners of this prestigious award have been for four years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.
dr hab. n. med. Kamila Kusz-Zamelczyk
mgr Anna Spik
dr n. med. Marcin Sajek
prof. dr hab. n. biol. Jadwiga Jaruzelska
Award from The Polish Society of Genetics
For the best paper published in 2013 in the field of human genetics, describing studies conducted in a Polish laboratory