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prof. dr hab. n. med. i n. o zdr. Maciej Giefing

I graduated Biotechnology at the Adam Mickiewicz University in Poznań in 2004 and the same year was employed at the Institute of Human Genetics (Polish Academy of Sciences) in Poznań . During my PhD studies I became interested in cancer genetics. My thesis was based on the analysis of chromosomal aberrations aimed at the identification of novel tumor suppressor genes in head and neck cancer and classical Hodgkin lymphoma. I started also a still vivid collaboration with German research groups from the German Hodgkin Study Group that resulted in an international PhD (promoters: Siebert R, Szyfter K.) that I defended in 2008 in the Institute of Human Genetics in Poznań .

Thereafter I continued my research on cancer genetics. I spent three years on a post-doc position in the Institute of Human Genetics, Christian Albrecht’s University in Kiel / Germany concentrating on the genetics of classical Hodgkin Lymphoma.

After my return to Poland I obtained the habilitation degree in 2014 for a series of publications entitled Identification of genes related to classical Hodgkin lymphoma pathogenesis. In 2015 I became head of the Department of Cancer Genetics at the Institute of Human Genetics in Poznań where we research the genome and epigenome of cancer cells.

Publications

FISH and FICTION in Lymphoma Research.

Giefing M, Sawicz G, Siebert R

In: Lymphoma. Methods and Protocols. Third Edition. Methods in Molecular Biology, vol. 2865, doi.10.1007/978-1-0716-4188-0_9, Humana Press, 2025, ISBN 978-1-0716-4187-3, ed.: Rafl Kuppers.pp-1-493.

MNiSW-20

Long read sequencing identifies complex structural variant landscape and recurrent TERT rearrangements in mucoepidermoid carcinoma.

Gensterblum-Miller E, Bhangale A, Majid D Al, Pienkowski VM, Rydzanicz M, Janiszewska J, Kostrzewska-Poczekaj M, Chang C, Brummel C, Michmerhuizen NL,Wang J, Sandford E, Tewari M, Wierzbicka M, Birkeland AC, McHugh JB, Spector ME, Giefing M, Jarmuz-Szymczak M, Heft Neal ME, Brenner JC

Oral Oncology, 2024, Volume 159, doi: 10.1016/j.oraloncology.2024.107108

IF-4.0 MNiSW-140

Transcriptional reprogramming by mutated IRF4 in lymphoma.

Schleussner N, Cauchy P, Franke V, Giefing M, Fornes O, Vankadari N, Assi SA, Costanza M, Weniger MA, Akalin A, Anagnostopoulos I, Bukur T, Casarotto MG, Damm F, Daumke O, Edginton-White B, Gebhardt JCM, Grau M, Grunwald S, Hansmann ML, Hartmann S, Huber L, Kärgel E, Lusatis S, Noerenberg D, Obier N, Pannicke U, Fischer A, Reisser A, Rosenwald A, Schwarz K, Sundararaj S, Weilemann A, Winkler W, Xu W, Lenz G, Rajewsky K, Wasserman WW, Cockerill PN, Scheidereit C, Siebert R, Küppers R, Grosschedl R, Janz M, Bonifer C, Mathas S

Nature Commun, 2023 Nov 7; 14 (1): 6 947. doi: 10.1038/s41467-023-41954-8.

IF-16.6 MNiSW-200

Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.

López C, Schleussner N, Bernhart SH, Kleinheinz K, Sungalee S, Sczakiel HL, Toprak UH, Wagener R, Bens S, Giefing M, González Sánchez JC, Jan M, Kreuz M, Mottok A, Müller JN, Seufert J, Hoffmann S, Korbel JO, Russell RB, Schüle R, Trümper L, Klapper W, ICGC MMML-Seq Consortium, Schlesner M, Mathas S, Siebert R

Haemotologica, 2023 Feb, 109 (2):543-554, Epub 2022 Apr 28, doi./10.3324/haematol.2021.280005

IF-10.1 MNiSW-140

Loss of function mutations of BCOR in classical Hodgkin lymphoma.

Giefing M, Gearhart MD, Schneider M, Overbeck B, Klapper W, Hartmann S, Ustaszewski A, Weniger MA, Wiehle L, Hansmann ML, Melnick A, Beguelin W, Sundrom Ch, Kuppers R, Bardwell VJ, Siebert R

Leukemia and Lymphoma, 2022, 63 (5): 1080-1090, doi: 10.1080/10428194.2021.2015587

IF-3,280 MNiSW-70

Events

Date:
18-21.03.2019 Where:
Gebze, Turcja

Wykład: „The role of transcription factors and miRNA in the pathogenesis of classical Hodgkin lymphoma” jako visiting professor na Gebze Technical University

Date:
15-17.12.2017 Where:
Poznań

„Mutations of the DIAPH2 gene in head and neck cancer are overrepresented in metastasizing tumors and result in a shift from “proliferation” to “migration” cellular phenotype” 27th Bilateral Symposium Poznan-Halle.

Date:
22-24.03.2017 Where:
Poznań

Referat: „Mutations of the DIAPH2 gene in head and neck cancer are overrepresented in metastasizing tumors and may impair actin polymerization and contribute to the metastatic potential of tumor cells” 9th International Conference of Contemporary Oncology.

Date:
22-25.10.2016 Where:
Kolonia, Niemcy

Referat: „The lymphoid cell specific transcription factor ELF-1 is transcriptionally downregulated and recurrently deleted in classical Hodgkin lymphoma (cHL)”

Date:
20-21.10.2016 Where:
Poznań

Referat: “Targeted deep sequencing of cancer related genes in human neoplasms” 6th Polish Illumina Sympsium

Date:
19.01.2016 Where:
Poznań

Referat: “PTPRD – epigenetycznie wyciszony gen supresji nowotworowej w płaskonabłonkowym raku krtani (LSCC)” seminarium Instytuty Genetyki Człowieka PAN w Poznaniu

Awards

Awarded:
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr hab. n. med. i n. o zdr. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
Award of the Division of Medical Sciences of the Polish Academy of Sciences
Given by: Division of Medical Sciences of the Polish Academy of Sciences

for 5 publications concerning loss of tumor suppressor genes in squamous cell carcinoma

Awarded: prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Powołanie na członka Rady Naukowej Instytutu Genetyki Człowieka PAN w Poznaniu na kadencję 2019-2022.
Given by: Rada Naukowa Instytutu Genetyki Człowieka PAN

Awarded: prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Ekspert Komisji Europejskiej powołany do oceny wniosków w ramach programu H2020-MSCA-IF-2016, Poznań 2016, 2017, 2018, 2019
Given by: Komisja Europejska

Awarded: prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Powołanie na członka Rady Wydziału Lekarskiego I Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu od roku 2016.
Given by: Rada Wydziału Lekarskiego I Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu

Awarded:
dr n. med. Kinga Bednarek
prof. dr hab. n. med. Krzysztof Szyfter
dr hab. n. med. Małgorzata Jarmuż-Szymczak
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Award.
Given by: Organizing Committee 31st Int. Congress of the International Academy of Pathology, European Society of Pathology.

Award for poster "The inorganic pyrophosphatase (PPA1) expression as the new potential metastatic parameter in laryngeal squamous cell carcinoma (LSCC)". 31st International Congress of the International Academy of Pathology, European Society of Pathology, Cologne, Germany, 25-29.09.2016 r.

Awarded: prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Powołanie na członka Rady Naukowej Instytutu Genetyki Człowieka PAN w Poznaniu na kadencję 2015-2018.
Given by: Rada Naukowa Instytutu Genetyki Człowieka PAN w Poznaniu

Awarded: prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Powołanie na członka Komitetu Genetyki Człowieka i Patologii Molekularnej – PAN na kadencję 2015-2018.
Given by: Komitet Genetyki Człowieka i Patologii Molekularnej

Awarded:
dr n. med. Kinga Bednarek
dr n. med. Magdalena Kostrzewska-Poczekaj
dr n. med. Marcin Szaumkessel
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
prof. dr hab. n. med. Krzysztof Szyfter
dr hab. n. med. Małgorzata Jarmuż-Szymczak
„Golden Helix”
Given by: Scientific committee of the IV Polish Congress of Genetics in the Oncogenetics section

Poster price „CDK1 – new oncogene in squamous cell carcinoma of the larynx?”

Awarded:
dr n. med. i n. o zdr. Joanna Janiszewska
dr n. med. Marcin Szaumkessel
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr n. med. Magdalena Kostrzewska-Poczekaj
prof. dr hab. n. med. Krzysztof Szyfter
Poster price
Given by: Scientific committee of the V Congress of Contemporary Oncology

Poster price „Search for novel tumor suppressor genes regulated by potentially oncogenic microRNA”

Awarded: prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Stypendium
Given by:

W ramach programu Ministra Nauki i Szkolnictwa Wyższego „Wsparcie międzynarodowej mobilności naukowców” umożliwiające wyjazd na staż naukowy do Instytutu Genetyki Człowieka, Christian Albrechts Universitat, Kiel; 03. 2009 – 02. 2012.