I have been working in the Institute of Human Genetics PAS since 2008. As a PhD student I performed functional studies of heterozygous mutations in the NBN gene, which encodes a protein involved in DNA double-strand break repair. After obtaining PhD in 2012, I moved to study the non-coding RNAs in hematological malignancies. In 2015-2016 I was a post-doctoral fellow at the University Medical Centre Groningen, the Netherlands, in the group of prof. Anke van den Berg. I studied the role of microRNA and long non-coding RNA in B-cell lymphoma. Back in the Institute, I continue this line of research in collaboration with prof. van den Berg. I am particularly interested in MYC-regulated non-coding RNA and to study them I use high-throughput screening approaches using shRNA and CRISPR/Cas9.
dr hab. n. med. i n. o zdr. Agnieszka Dzikiewicz-Krawczyk
Publications
Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR‑150 binding capacity.
Liu Y, Zhao X, Seitz A, Hooijsma AA, Ravanbakhsh R, Sheveleva S, de Jong D, Koerts J, Dzikiewicz-Krawczyk A, van den Berg A, Ziel-Swier LJYM, Kluiver J
Sci Rep, 2024 Apr 16;14(1):8730. doi: 10.1038/s41598-024-59443-3IF-3.8 MNiSW-140
Identification of ATM-dependent long non-coding RNAs induced in response to DNA damage.
Podralska M, Sajek MP, Bielicka A, Żurawek M, Ziółkowska-Suchanek I, Iżykowska K, Kolenda T, Kazimierska M, Kasprzyk ME, Sura W, Pietrucha B, Cukrowska B, Rozwadowska N, Dzikiewicz-Krawczyk A
DNA Repair (Amst), 2024, 135 March: 103648. doi: 10.1016/j.dnarep.2024.103648, Epub 2024 Feb 15IF-3,0 MNiSW-140
Inhibition of the glutamate cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells.
Kazimierska M,·Leśniewska A, Bakker A, Diepstra A, Kasprzyk ME, Podralska M, Rassek K, Kluiver J, van den Berg A, Rozwadowska N, Dzikiewicz Krawczyk A
J Appl Genet, 2024 Feb, 65 (1): 95-101, doi.10.1007/s13353-023-00797-1, Epub 2023 Nov 2IF-2.0 MNiSW-140
CRISPR/Cas9 screen for genome-wide interrogation of essential MYC-bound E-boxes in cancer cells.
Kazimierska M, Podralska M, Żurawek M, Woźniak T, Kasprzyk ME, Sura W, Łosiewski W, Ziółkowska-Suchanek I, Kluiver J, van den Berg A, Rozwadowska N, Dzikiewicz-Krawczyk A
Molec Oncol, Epub 2023 Nov, 17 (11): 2295-2213, doi: 10.1002/1878-0261.13493, Epub Aug 7IF-6.6 MNiSW-140
Non-coding RNAs: Mechanisms of action. Chapter 3.
Kasprzyk M, Kazimierska M, Sura W, Dzikiewicz-Krawczyk A, Podralska M
Navigating Non-coding RNA from Biogenesis to Therapeutic Application, 2023, Academic Press, Elsevier, ed: Sztuba-Solińska J; ISBN978-0-323-90406-3MNiSW-80
TransCRISPR – sgRNA design tool for CRISPR/Cas9 experiments targeting DNA sequence motifs A.
Woźniak T, Sura W, Kazimierska M, Kasprzyk ME, Podralska M, Dzikiewicz-Krawczyk A.
Nucleic Acids Res, 2023 Jul 5 (W1): W577-W586. doi: 10.1093/nar/gkad355 Eub May 9IF-14.9 MNiSW-200
Obituary—Pieter Van Vlierberghe (1980–2022).
Dawidowska M, Dzikiewicz-Krawczyk A, Rozwadowska N, Ntziachristos P, Kluiver J, van den Berg A, Siebert R, Giefing M
Leukemia 2023; doi: 10.1038/s41375-023-01825-z
The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cells.
Winkle M, Tayari MM, Kok K, Duns G, Grot N, Kazimierska M, Seitz A, Jong D, Koerts J, Diepstra A, Dzikiewicz-Krawczyk A, Steidl C, Kluiver J, van den Berg A
IF-5,121
Punkty-140
IF-5,121 MNiSW-140
C10orf55, CASC2, and SFTA1 lncRNAs Are Potential Biomarkers to Assess Radiation Therapy Response in Head and Neck Cancers
Paszkowska A, Kolenda T, Guglas K, Kozłowska-Masłoń J, Podralska M, Teresiak A, Bliźniak R, Dzikiewicz-Krawczyk A, Lamperska K
J Person Med (MDPI), .2022 Oct, 12 (10): 1696, 18 str,IF-3,508 MNiSW-70
Where Do We Stand in the Behavioral Pathogenesis of Inflammatory Bowel Disease? The Western Dietary Pattern and Microbiota—A Narrative Review.
Krela-Kaźmierczak I, Zakerska-Banaszak O, Skrzypczak-Zielińska M, Łykowska-Szuber L, Szymczak-Tomczak A, Zawada A, Rychter AM, Ratajczak AE, Skoracka K, Skrzypczak D, Marcinkowska E, Słomski R, Dobrowolska A
Nutrients (MDPI), 2022, 14 (12), 252, 28 str, doi/10.3390/nu14122520IF-5,719 MNiSW-140
All publications
Events
18-19 Sep 2017 Where:
Poznan, Poland
RNAtion – Computational and Experimental RNA Biology Conference for Young Scientists
Oral presentation: Two faces of RNA: unraveling the role of protein-coding and non-coding ZDHHC11/B transcripts in Burkitt lymphoma
13-16 Sep 2017 Where:
Heidelberg, Germany
, EMBO|EMBL Symposium: The Non-Coding Genome
Oral presentation: ZDHHC11 and ZDHHC11B are novel critical components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma
21-24 Feb 2016 Where:
Santa Fe, USA
Keystone Symposium: Noncoding RNAs in Health and Disease
Poster: Identification of target genes of the MYC-repressed tumor supressor miRNA-150 in Burkitt lymphoma
20-22 Jan 2016 Where:
Papendal , The Netherlands
10th Dutch Hematology Congress
Oral presentation : Identification of target genes of the MYC-repressed tumor supressor miRNA-150 in Burkitt lymphoma
11-15 June 2014 Where:
Milan, Italy
19th Congress of the European Hematology Association
Poster : A functional polymorphism in the 3’ untranslated region of the ARHGAP26 gene confers an increased risk of chronic myeloid leukemia and causes illegitimate regulation by microRNA-18a-3p
10-13 Sep 2013 Where:
Poznan, Poland
4th Polish Congress of Genetics
Oral presentation: MicroRNA binding sites polymorphisms and the risk of pediatric acute lymhoblastic leukemia and adult myeloid leukemias
12-15 Sep 2010 Where:
Lublin, Poland
3rd Polish Congress of Genetics
Poster: Impact of heterozygous NBN gene mutations on nibrin functions
Awards
dr n. chem. Tomasz Woźniak
dr n. biol. Weronika Sura
dr hab. n. med. i n. o zdr. Agnieszka Dzikiewicz-Krawczyk
nagroda za publikację
Komitet Biologii Molekularnej Komórki Polskiej Akademii Nauk nagrodził pracę Woźniak T, Sura W, Kazimierska M, Kasprzyk ME, Podralska M, Dzikiewicz-Krawczyk A. TransCRISPR-sgRNA design tool for CRISPR/Cas9 experiments targeting specific sequence motifs Nucleic Acids Research, 2023; 51(W1): W577-W586 w konkursie im. prof. W. Krzyżosiaka.
FIRST TIME
Do konkursu zgłoszono 131 wniosków, z których 13 zostało zarekomendowanych do finansowania ze środków z Programu Operacyjnego Inteligentny Rozwój (PO IR) Fundacji Nauki Polskiej, wśród nich znalazł się projekt dr Agnieszki Dzikiewicz-Krawczyk pt. "Funkcjonalna analiza regionu regulatorowego genu IGH w chłoniakach nieziarniczych z komórek B".
