dr n. med. Patrycja Daca-Roszak

I am an Assistant Professor at the Department of Molecular and Clinical Genetics. My research interests include molecular human population diversity in both cognitive and application aspects. In my work, I use a variety of molecular methods, including high-throughput methods (microarrays, next generation sequencing).
Research projects:
NN303307737: Mitochondrial DNA phylogeny in Polish subpopulations- ethnogenetic and identification aspects”- Head of the PhD grant

AriaDNA OR00 0027 12: Analysis of gene, transcriptome and methylome variability at the cellular level in human population to forensic identification purpose- Principal investigator in the R&D subproject

Publications

The effect of library preparation protocol on the efficiency of heteroplasmy detection in mitochondrial DNA using two massively parallel sequencing Illumina systems.

Daca-Roszak P, Fiedorowicz J, Jankowski M, Ciecielka M, Teresiński G, Lipska-Ziętkiewicz B, Ziętkiewicz E, Grzybowski T, Skonieczna K

J Appl Genetics,2024 65 (3): 559-563, doi.10.1007/s13353-023-00821-4, Epub 2023 Dec 19

IF-2.0 MNiSW-140

Estimation of the Age of the Kashubian-Specific Pathogenic NPHS2 Variant Responsible for Hereditary Steroid-Resistant Nephrotic Syndrome Points to Its Recent Local Origin.

Jankowski M, Daca-Roszak P, Bałasz-Chmielewska J, Ustaszewski A, Żurowska A, Lipska-Ziętkiewiz BS, Ziętkiewicz E

Human Mutation, 2024, Article ID 8205102, 9 pages, https://doi.org/10.1155/2024/8205102

IF-3.3 MNiSW-140

Genetyczna różnorodność współczesnych populacji ludzkich.

Ziętkiewicz E, Daca-Roszak P

W: Genetyka medyczny i molekularna, pod red. J. Bala, Rozdział 4, PWN, ISBN: 978-83-01-23089-0, 2023, str. 47-67.

MNiSW-80

Genetic diversity in Kashubs: the regional increase in the frequency of several disease-causing variants.

Jankowski M, Daca‑Roszak P, Obracht‑Prondzyński C, Płoski R, Lipska‑Ziętkiewicz BS, Ziętkiewicz E

J Applied Genetics, 2022 Dec, 63 (4): 691-702, https://doi.org/10.1007/s13353-022-00713-z Epub 2022 Aug 15

IF-2,653 MNiSW-140

In vitro differentiation of ciliated cells in ALI-cultured human airway epithelium - The framework for functional studies on airway differentiation in ciliopathies.

Bukowy-Bieryłło Z, Daca-Roszak P, Jurczak J, Przystałowska-Macioła H, Jaksik R, Witt M, Ziętkiewicz E

European Journal of Cell Biology, 101, 2022; 151189, doi.org/10.1016/j.ejcb.2021.151189

IF-4,492 MNiSW-100

Mild X-linked Alport syndrome due to the COL4A5 G624D variant originating in the Middle Ages is predominant in Central/East Europe and causes kidney failure in midlife.

Żurowska AM, Bielska O, Daca-Roszak P, Jankowski M, Szczepańska M, Roszkowska-Bjanid D, Kuźma-Mroczkowska E, Pańczyk-Tomaszewska M, Moczulska A, Drożdż D, Hadjipanagi D, Deltas C, Ostalska-Nowicka D, Rabiega A, Taraszkiewicz J, Taranta-Janusz K, Wieczorkiewicz-Plaza A, Jobs K, Mews J, Musiał K, Jakubowska A, Nosek H, Jander AE, Koutsofti C, Stanisławska-Sachadyn A, Kuleszo D, Ziętkiewicz E, Lipska-Ziętkiewicz BS

Kidney Internatl, 2021, 99 (6): 1451-8, Epub 2020 Dec 10, doi:10.1016/j.kint.2020.10.040

IF-8,945 MNiSW-140

Discrimination between human populations using a small number of differentially methylated CpG sites: A preliminary study using lymphoblastoid cell lines and peripheral blood samples of Caucasian and Chinese origin.

Daca-Roszak P, Jaksik R J; Paczkowska J; Witt M; Zietkiewicz E

BMC Genomics, 2020, 21: 706), Epub Oct 12

IF-3,594 MNiSW-140

Publications

The effect of library preparation protocol on the efficiency of heteroplasmy detection in mitochondrial DNA using two massively parallel sequencing Illumina systems.

Estimation of the Age of the Kashubian-Specific Pathogenic NPHS2 Variant Responsible for Hereditary Steroid-Resistant Nephrotic Syndrome Points to Its Recent Local Origin.

Genetyczna różnorodność współczesnych populacji ludzkich.

Genetic diversity in Kashubs: the regional increase in the frequency of several disease-causing variants.

In vitro differentiation of ciliated cells in ALI-cultured human airway epithelium - The framework for functional studies on airway differentiation in ciliopathies.

Mild X-linked Alport syndrome due to the COL4A5 G624D variant originating in the Middle Ages is predominant in Central/East Europe and causes kidney failure in midlife.

Discrimination between human populations using a small number of differentially methylated CpG sites: A preliminary study using lymphoblastoid cell lines and peripheral blood samples of Caucasian and Chinese origin.

Transcriptome variation in human populations and its potential application in forensics.

CFAP300 mutations in Slavic primary ciliary dyskinesia patients in ciliary dynein arms trafficking.

Identification of endogenous control miRNAs for RT-qPCR in T-cell acute lymphoblastic leukemia.

All publications

See also

Alicja Rabiasz

Hanna Przystałowska-Macioła

Joanna Jurczak

Jan Zięba

Małgorzata Dawidowska

Monika Drobna-Śledzińska

Maria Kosmalska

Zuzanna Bukowy-Bieryłło