Department of Nucleic Acid Function focuses on research into the pathogenesis and treatment of inflammatory bowel disease (IBD) and other disorders associated with the gastrointestinal tract. We use NGS and QF PCR technologies to determine the composition of the gut microbiota and the microbiota of different environments. We are experienced in designing targeted NGS panels for the needs of our pharmacogenetic studies, as well as in analyzing high-throughput data. We analyze gene variants associated with the disease's etiology for research and diagnostic purposes. We are also experienced in the identification of genetic material (DNA profiling) using STR markers, in human, animal material, and in vitro cultured cell lines.
Department of Nucleic Acid Function
Featured publications
MicroRNA Expression Profile Is Altered by Short-Term and Chronic Lithium Treatment in a Rat Model of Depression.
Kachel M, Dola A, Kubiak M, Majewska W, Nowakowska J, Langwiński W, Hryhorowicz S, Szczepankiewicz A
J Mol Neurosci. 2024 Dec 15; 74 (4): art. 116, 13 stron, . doi: 10.1007/s12031-024-02298-0IF-2.8 MNiSW-70
PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking.
Forman TE, Sajek MP, Larson ED, Mukherjee N, Fantauzzo KA
eLife, 2024, 13: RP98531, doi: 10.7554/eLife.98531IF-6.4 MNiSW-200
Germline polymorphisms of the NOD2 pathway may predict the effectiveness of radioiodine in differentiated thyroid cancer treatment.
Borowczyk M, Kaczmarek-Ryś M, Hryhorowicz S, Sypniewski M, Filipowicz D, Dobosz P, Oszywa M, Ruchała M, Ziemnicka K
J Endocrinol Invest, 2024, 4 (12): 2969-2980, Epub 2024 May 16. doi: 10.1007/s40618-024-02389-0IF-3.9 MNiSW-100
Evolutionary dynamics of polyadenylation signals and their recognition strategies in protists.
Sajek MP, Bilodeau DY, Beer MA, Horton E, Miyamoto Y, Velle KB, Eckmann L, Fritz-Laylin L, Rissland OS and Mukherjee N
Genome Res. 2024 Oct 29;34 (10):1570-1581. doi: 10.1101/gr.279526.124, Epub Sep 26IF-6.2 MNiSW-200
The Prevalence of Cancer Predisposition Syndromes (CPSs) in Children with a Neoplasm: A Cohort Study in a Central and Eastern European Population.
Telman-Kołodziejczyk G, Strauss E, Sosnowska-Sienkiewicz P, Januszkiewicz-Lewandowska D
Genes (Basel, MDPI). 2024 Aug 29;15(9):1141. doi: 10.3390/genes15091141.IF-2.8 MNiSW-100
Clinical Trial: A Pragmatic Randomised Controlled Study to Assess the Effectiveness of Two Patient Man agement Strategies in Mils ro Moderate Ulcerative Colitis - The OPTIMISE Study.
Danese S, Fiorino G, Vicaut E, Paridaens K, Ugur A, Clark B, Vanasek T, Stepek D, D=Amico F, West R, Gilissen LPL, Wisniewska-Jarosinska M, Drobinski P, Fronik G, Fic M, Walczak M, Kowalski M, Korczowski B, Wiatr M, Peyrin-Biroulet L
J Clin Med (MDPI), 2024, 13, 5147, doi: 10.3390/jcm13175147IF-3.0 MNiSW-100
Novel genetic variants potentially associated with the pathogenesis of coronary artery aneurysm: whole-exome sequencing analysis.
Iwańczyk S, Lehmann T, Pławski A, Woźniak P, Hertel A, Araszkiewicz A, Stępień K, Krupka G, Grygier M, Lesiak M, Jagodziński P
Hellenic Journal of Cardiology, 2024, 79: 84-85.IF-2.7 MNiSW-40
The role of host genetics and intestinal microbiota and metabolome as a new insight into IBD pathogenesis.
Zakerska-Banaszak O, Zuraszek-Szymanska J, Eder P, Ładziak K, Słomski R, Skrzypczak-Zielińska M
Int J Mol Sci, (MDPI), 2024 Sep 4; 25 (17):9589, 21 stron, doi: 10.3390/ijms25179589IF-4.9 MNiSW-140
Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains.
Banerjee A, Ataman M, Smialek MJ, Mookherjee D, Rabi J, Mironov A, Mues L, Enker L, Coto/Llerena M, Schmidt A, Boehringer D, Piscuoglio S, Spang A, Mittal N, Zavolan M
Nucleic Acids Research, 2024, 52: 9028-9048IF-16.6 MNiSW-200
Low-Penetrance Susceptibility Variants in Colorectal Cancer-Current Outlook in the Field.
Szuman M, Kaczmarek-Ryś M, Hryhorowicz S, Kryszczyńska A, Grot N, Pławski A
Int J Mol Sci. (MDPI), 2024 Jul 30; 25 (15):8338, 21 str., doi: 10.3390/ijms25158338.IF-4.9 MNiSW-140
All publications
Featured research projects
1. Acronym MEDPIG, INNOMED/I/17/NCBR/2014
“Development of an innovative technology for using transgenic pig tissues for biomedical purposes”
Task no 5. Development and characterization of new gene construct for transgenesis.
Obtained financial support from the National Centre for Research and Development from the funds of the Operational Programme Innovative Economy within the framework of the European Regional Development Fund.
Agreement no INNOMED 1/20106/07/2013/6
Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2014-2017
2. Acronym ONKOKAN, INNOMED/I/11/NCBR/2014
“Development of technology for obtaining cannabinoids from hemp with low THC content as agents supporting treatment for cancer patients”
Task no 7. Assessment of genetic polymorphisms and genes expression involved in the metabolism of cannabinoids and response to their application in the Polish population
Agreement no INNOMED 1/20104/07/2013/7
Project leader: prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Task leader no 5. prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2014-2017
3. “Sharing Advances on Large Animal Models (SALAAM)”
COST Action BM1308. Management Committee Member.
Coordinator Prof. Eckhard Wolf (Germany)
http://www.salaam.genzentrum.lmu.de
http://www.cost.eu/COST_Actions/bmbs/Actions/BM1308
MC member – prof. dr hab. Ryszard Słomski, Poznan Life Sciences University
Duration of the project: 19.05.2014-18.05.2018
4. UDA/POIG.01.04.00-24-002/11-00
Operational Programme Innovative Economy 2007-2013 under Measure 1.4 Support for special projects of priority axis 1 Research and development of new technologies. „Development studies on efficient technology of production fluid into renal transplantation,
Project leader: Prof. dr hab. n. med. Florian Ryszka, Pharmaceutical Research and Production Plant „BIOCHEFA”
Research task „Development of the methodology to determine the zygosity of pigs for xenotransplantation of kidney and reproducible animal model”
Task leader: prof. dr hab. Ryszard Słomski, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2012-2013
5. Ministry of Science and Higher Education N N303 457238
“Investigation of the degree of genetic determination in prenatal testing – analysis of genetic variability in twins”
Project leader : prof. dr hab. Krystyna Cieślik, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2010-2014
6. Ministry of Science and Higher Education N N401 037838
“Analysis of gene polymorphisms influenced on reaction to anaesthetics in patients under general anaesthesia and on reaction to analgetics in the postoperative period”
Project leader : dr Adam Mikstacki, Institute of Human Genetics, Polish Academy of Science in Poznan, Poland
Duration of the project: 2010-2014
7. Development project N R13 0018 06
„Inhibition of the activation of the coagulation system and systemic inflammatory response during extracorporeal respiratory support in an animal model”
Project leader : dr Wiesław Zygmunt Królikowski, CM UJ
Task: Analysis of genetic variability of pigs for somatic cloning and xenotransplantation .
Task leader: prof. dr hab. Z. Smorąg, współpraca prof. R. Słomski
Duration of the project: 2009-2012
Collaborations
Poznań University of Life Sciences, Department of Biochemistry and Biotechnology, Poland.
National Research Institute of Animal Production in Balice, Poland.
Poznań University of Medical Sciences, Poland.
Foundation of Cardiac Surgery Development, Poland.
Burns Treatment Centre in Siemianowice Śląskie, Poland.
Laboratory of Molecular Genetics in Poznań, Poland.
Institute of Natural Fibres and Medicinal Plants, Poland.
PozLab sp. z o.o. (Ltd), Poland.
Adam Mickiewicz University in Poznań, NanoBioMedical Centre, Poland.
Awards
In the competition for the best original work of a doctoral student in 2022 organized by The Poznan Branch of the Polish Academy of Sciences, MSc Erkut Ilaslan won the main prize in the field of medical sciences.
Awarded publication:
Ilaslan E, Kwiatkowska K, Smialek MJ, Sajek MP, Lemanska Z, Alla M, Janecki DM, Jaruzelska J, Kusz-Zamelczyk K „Distinct Roles of NANOS1 and NANOS3 in the Cell Cycle and NANOS3-PUM1-FOXM1 Axis to Control G2/M Phase in a Human Primordial Germ Cell Model. IJMS, 2022, 13;23(12):6592.
The Golden Hundred of Polish Agriculture. Gala "Wprost" 2022.
In the category of Innovations in the agricultural and food industry, the Institute of Natural Fibres and Medicinal Plants National Research Institute was awarded, which is the only research centre in Poland with almost 90 years of experience in work on hemp. Director of the Institute Dr. Eng. n. med. Rafał Spachacz said that we are happy that we can work together to implement a non-fiber hemp cultivation program and this award is a mobilization for us to further action. Together with the director, the award was received by prof. dr hab. Ryszard Słomski, MD, Katarzyna Wielgus, Paweł Gała, PhD, and Karolina Wielgus, PhD. Institute of Human Genetics PAS represented by prof. Słomski previously implemented the Innomed project. Development of a technology for obtaining cannabinoids from hemp with a low THC content as means supporting the treatment of oncological patients. Acronym: ONKOKAN.
The First Prize in the competition for the best papers “Molecules 2020 Best Paper Award for Anniversary Special Issues”, published in the “Anniversary Special Issues”.
The award was granted for the publication of:
„Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology”
Aleksandra Zielińska, Filipa Carreiró, Ana M. Oliveira, Andreia Neves, Bárbara Pires, D. Nagasamy Venkatesh, Alessandra Durazzo, Massimo Lucarini, Piotr Eder, Amélia M. Silva, Antonello Santini and Eliana B. Souto. Molecules 2020, 25(16), 3731; DOI: 10.3390/molecules25163731
Molecules (ISSN 1420-3049) IF 4.927; Min 140.
Nagroda im. Prof. W. Bielańskiego przyznana przez Towarzystwo Biologii Rozrodu za dwa powiązane ze sobą artykuły oryginalne opublikowane w 2020 roku.
za dwa powiązane ze sobą artykuły oryginalne opublikowane w 2020 roku.
Head of Local Self-Parliament
Prof. Krzysztof Szyfter was awarded by Marek Woźniak, the Head of Local Self-parliament for his merits to Great-Poland District.
prof. dr hab. n. biol. Jadwiga Jaruzelska
dr n. med. Marcin Sajek
dr n. med. Maciej Śmiałek
mgr Erkut Ilaslan
Award of the Faculty of Medical Sciences of the Polish Academy of Sciences
Prof. Jadwiga Jaruzelska, dr Marcin Piotr Sajek, dr Maciej Jerzy Śmiałek and Ms Erkut Ilaslan were awarded by Medical Division of the Polish Academy of Sciences for 5 articles entitled: “Role of NANOS and PUM proteins in human reproduction and infertility”.
Prize of the Prime Minister of the Republic of Poland
Dr Maciej Jerzy Śmiałek was awarded a Prize of the Prime Minister of the Republic of Poland for his PhD dissertation „A global identification of mRNAs regulated by PUM1 and PUM2 and their protein cofactors, in the model of human seminoma (TCam-2)”defended in 2020.
FNP START 2021 Program.
Dr Aleksandra Zielińska from the Department of Nucleic Acids Function of our Institute has become a laureate of the FNP START 2021 Program.
Officer's Cross of the Order of Polonia Restituta.
Prof. dr hab. n. med. Ryszard Słomski was decorated with the Officer's Cross of the Order of Polonia Restituta. The ceremony took place on June 7, 2021 at the Wielkopolska Voivodship Office in Poznań. The Cross was awarded by the President of the Republic of Poland, Andrzej Duda, on the Professor's 70th birthday. Due to the pandemic, the handing over was delayed by a year and a half. The Order was awarded for the Professor's scientific and research activities, including pioneering DNA studies in the country for diagnostic, medical and forensic purposes, as well as the implementation and dissemination of molecular diagnostics (DNA fingerprinting 1987; PCR polymerase chain reaction 1989). Works in the field of medical biotechnology constitute an important field of interest and include obtaining of transgenic animals as bioreactors for the production of peptides and tissues for xenotransplantation. Biological dressings made of the skin of transgenic pigs have been used many times in the Burn Treatment Center in Siemianowice Śląskie.