Our scientific interests concentrate on cancer genetics and the genetics of the senses. We use various techniques in our routine practice, from molecular biology and cytogenetics (microarrays, NGS, pyrosequencing, FISH and FICTION) supplemented by functional analyses. The aim of the research is the identification of genomic and epigenomic alterations that contribute to the development of neoplasms and diseases of the sensory organs. To that end, we work closely with renowned Polish and foreign scientific groups.
Department of Cancer Genetics
Featured publications
Estimation of the Age of the Kashubian-Specific Pathogenic NPHS2 Variant Responsible for Hereditary Steroid-Resistant Nephrotic Syndrome Points to Its Recent Local Origin.
Jankowski M, Daca-Roszak P, Bałasz-Chmielewska J, Ustaszewski A, Żurowska A, Lipska-Ziętkiewiz BS, Ziętkiewicz E
Human Mutation, 2024, Article ID 8205102, 9 pages, https://doi.org/10.1155/2024/8205102IF-3.9 MNiSW-140
Differentially expressed microRNAs targeting genes in key pathways in keratoconus.
Nowak-Malczewska D, Świerkowska J, Gajęcka M
Front Genetics, 2024 Feb 26, 15, Manuscript ID: 1301676, doi 10.3389/fgene.2024.1301676IF-3.7 MNiSW-100
Defining the mutational profile of lower-risk myelodysplastic neoplasm patients with respect to disease progression using next-genetation sequencing and pyrosequencing.
Adamska M, Kowal-Wiśniewska E, Czerwińska-Rybak J, Kiwerska K, Barańska M, Gronowska W, Loba J, Brzeźnikiewicz-Janus K, Wasilewska E, Łanocha A, Jarmuż-Szymczak M, Gil L
Contempor Oncol, 2023, 27 (4): 269-276, doi: 10.5114/wo.2023.135365IF-1.8 MNiSW-70
Macrolide and Lincosamide Resistance of Streptococcus agalactiae in Pregnant Women in Poland.
Kamińska D, Ratajczak M, Nowak-Malczewska DM, Karolak JA , Kwaśniewski M, Szumala-Kąkol A, Długaszewska J, Gajęcka M
Scientific Reports, 2024 Feb 16;14 (1): 3877, 8 stron,. doi: 10.1038/s41598-024-54521-y.IF-4.6 MNiSW-140
Statistical Analysis of the Content of Metals in Blood Serum and in the Alternative Material in Head and Neck Carcinoma.
Herman M, Jakubowska M, Piekoszewski W, Woźniak A, Przybyłowicz A, Szukalska M, Golusińska-Kardach E, Gawęcki W, Czarnywojtek A, Walas A, Golusiński W, Ruchała M, Szyfter K, Ferlito A, Florek E
Arabian J Chemistry, 2024, 17 (3), art105577, 11 stron, doi: 10.1016/j.arabjc.2023.10557IF-6.0 MNiSW-70
Acute Myeloid Leukemia Post Cytotoxic Therapy in Breast Cancer Survivors—Over 23 Years of Single Center Analysis.
Adamska M, Kowal-Wiśniewska E, Barańska M, Przybyłowicz-Chalecka A, Łojko-Dankowska A, Joks M, Jarmuż-Szymczak M, Gil L
J Clin Med (MDPI), 2024, 13, 989, 17 str. doi. 10.3390/ jcm13040989IF-3.9 MNiSW-140
Rationale for Increasing Oncological Vigilance in Relation to Clinical Findings in Accessory Parotid Gland-Observations Based on 2192 Cases of the Polish Salivary Network Database.
Wierzbicka M, Bartkowiak E, Pietruszewska W, Stodulski D, Markowski J, Burduk P, Olejniczak I, Piernicka-Dybich A, Wierzchowska M, Amernik K, Chańko A, Majszyk D, Bruzgielewicz A, Gazinska P, Mikaszewski B
Cancers (Basel, MDPI). 2024 Jan 22;16 (2): 463, 13 str, doi: 10.3390/cancers16020463.IF-5.2 MNiSW-140
Towards effectiveness of cell free DNA based liquid biopsy in head and neck squamous cell-carcinoma.
Kowal-Wiśniewska E, Jaśkiewicz K, Bartochowska A, Kiwerska K, Ustaszewski A, Górecki T, Giefing M, Paluszczak J, Wierzbicka M, Jarmuż-Szymczak M
Scientific Reports, 2024 Jan 26;14 (1): 2251, 11 stron, doi: 10.1038/s41598-024-52031-5IF-4.6 MNiSW-140
Effects of maternal type 1 diabetes and confounding factors on neonatal microbiomes.
Gajęcka M, Gutaj P, Jaśkiewicz K, Rydzanicz M, Szczapa T, Kamińska D, Kosewski G, Przysławski J, Płoski R, Wender-Ożegowska E
Diabetologia, 2024 Feb, 67 (2): 312-326, doi: 10.1007/s00125-023-06047-7 Epub 2023 Nov 29.IF-8.2 MNiSW-140
Robot-assisted cochlear implantation via a modified pericanal approach (artykuł dwujęzyczny)
Gawęcki W, Balcerowiak A, Podlawska P, Szyfter W, Wierzbicka M
Otolaryngol Pol, 2023; 77 (6): 18-23; doi: 10.5604/01.3001.0016.3414 doi: 10.5604/01.3001.0053.4090IF-0.6 MNiSW-140
All publications
Featured research projects
1. Project OPUS
„Genome-wide mutation screen of the regulome in laryngeal squamous cell carcinoma.”
Duration: 2017-2020
2. Project PRELUDIUM
„Role of miR-299-5p in pathogenesis of laryngeal squamous cell carcinoma.”
Duration: 2017-2020
3. Project OPUS
“The expression analysis of genes and proteins potentially involved in lymph node metastasis formation in laryngeal cancer”
Duration: 2016-2019
4. Project HARMONIA
“Identification of miRNAs involved in classical Hodgkin lymphoma pathogenesis using combined expression and mutation profiling and functional analyses.”
Duration: 2015-2018
5. Project HARMONIA
“Whole exome sequencing in Polish patients with sporadic keratoconus and a pilot study of keratoconus proteomic and metabolomic profiles of tears.”
Duration: 2014-2017
6. Project PRELUDIUM
“Silencing and functional analysis of the CDK1 gene in laryngeal squamous cell carcinoma.”
Duration: 2014-2017
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Collaborations
Department of Otolaryngology, Poznan University of Medical Sciences, Poznań, Poland.
Institute of Human Genetics, Christian Albrecht University, Kiel, Germany.
Institute of Cell Biology (Tumour Research), University Duisburg-Essen, Germany.
Senckenberg Institute of Pathology, Goethe University Frankfurt, Germany.
Department of Otorhinolaryngology – Head and Neck Surgery, University of Turku, Finland.
Department of Molecular and Human Genetics, Baylor College of Medicine Houston, TX, USA.
Awards
Awarded:
Given by:
Awarded:
dr n. med. i n. o zdr. Joanna Świerkowska
Nagroda Polskiego Towarzystwa Genetyki Człowieka za najlepszą pracę doktorską z zakresu genetyki człowieka
Nagroda Polskiego Towarzystwa Genetyki Człowieka za najlepszą pracę doktorską z zakresu genetyki człowieka
Given by: Polskie Towarzystwo Genetyki Człowieka (PTGC)
Podczas XI Zjazdu Polskiego Towarzystwa Genetyki Człowieka w Bydgoszczy, dr n. med. i n. o zdr. Joanna Świerkowska otrzymała Nagrodę Polskiego Towarzystwa Genetyki Człowieka za najlepszą pracę doktorską z zakresu genetyki człowieka – stopień doktora nadany w latach 2018-2020. Tytuł nagrodzonej pracy doktorskiej: „Charakterystyka wybranych aspektów (epi)–genetycznych w wysokiej krótkowzroczności u polskich pacjentów”.
Awarded:
mgr inż. Ewelina Kowal-Wiśniewska
Nagroda im. prof. Aleksandra Szczygła za pracę naukowo-badawczą opublikowaną w roku 2021
Given by: Polskie Towarzystwo Nauk Żywieniowych
za pracę naukowo-badawczą opublikowaną w roku 2021 z zakresu nauki o żywieniu człowieka: Alteration of the Early Development Environment by Maternal Diet and the Occurrence of Autistic-like Phenotypes in Rat Offspring.
Awarded:
dr n. med. Julia Paczkowska
IX Edition of the Competition of the Polish Academy of Sciences in Poznan for the best scientific publication, which was published in 2020 and the lead author was a PhD student.
Given by: Polish Academy of Sciences in Poznan
Dr Julia Paczkowska – lauerate of the IX Edition of the Competition of the Polish Academy of Sciences in Poznan for the best scientific publication, which was published in 2020 and the lead author was a PhD student.
Awarded:
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr hab. n. med. i n. o zdr. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
dr hab. n. med. Małgorzata Jarmuż-Szymczak
dr hab. n. med. i n. o zdr. Katarzyna Kiwerska
dr n. med. Magdalena Kostrzewska-Poczekaj
Award of the Division of Medical Sciences of the Polish Academy of Sciences
Given by: Division of Medical Sciences of the Polish Academy of Sciences
for 5 publications concerning loss of tumor suppressor genes in squamous cell carcinoma
Awarded:
dr n. med. i n. o zdr. Joanna Świerkowska
EMBO Short-term fellowship
Given by: EMBO
Joanna Świerkowska from the Department of Cancer Genetics received an EMBO short-term fellowship for the implementation of the project “The role of the noncoding miRNA and enhancers in high myopia” at Erasmus Medical Center, Rotterdam, The Netherlands
Awarded:
dr n. med. Magdalena Kostrzewska-Poczekaj
EMBO short-term fellowship
Given by: EMBO
Magdalena Kostrzewska-Poczekaj from the Department of Cancer Genetics received an EMBO short-term fellowship for the implementation of the project "Platelets and platelet microparticles (PMP) as omnipresent RNA messengers in inflammatory diseases" at University Hospital Schleswig Holstein, Clinic for Otorhinolaryngology - Head and Neck Surgery, Luebeck in Germany.
Awarded:
prof. dr hab. n. med. i n. o zdr. Maciej Giefing
Powołanie na członka Rady Naukowej Instytutu Genetyki Człowieka PAN w Poznaniu na kadencję 2019-2022.
Given by: Rada Naukowa Instytutu Genetyki Człowieka PAN
Awarded:
prof. dr hab. n. med. Marzena Gajęcka
Kosciuszko Foundation Fellowship
Given by: Kosciuszko Foundation
Prof. Marzena Gajecka has been awarded a Kosciuszko Foundation Fellowship for the academic year 2019/2020, to visit Baylor College of Medicine and Texas Children’s Hospital in Houston, TX, US. The Kosciuszko Foundation promotes closer ties between Poland and the United States through educational, scientific and cultural exchanges. The Kosciuszko Foundation annually awards a number of Fellowships/Grants to Poles for advanced study, research, and/or teaching at universities and other institutions of higher learning in the United States.
Awarded:
mgr Adam Ustaszewski
Msc Adam Ustaszewski otrzymał stypendium międzynarodowe (Short-Term Fellowship) przyznane przez Europejską Organizację Biologii Molekularnej (EMBO)
Given by: European Molecular Biology Organization (EMBO).
Mgr Adam Ustaszewski otrzymał stypendium międzynarodowe (Short-Term Fellowship) przyznane przez Europejską Organizację Biologii Molekularnej (EMBO) na projekt badawczy zatytułowany „Identification of putative alternations of open chromatin regions in Classical Hodgkin Lymphoma by integration of ATAC-Seq and high-throughput sequencing of cis-regulatory elements.”, przyznane przez Europejską Organizację Biologii Molekularnej (EMBO). Poznań. 24.01.2019 r.