The Department of Molecular and Clinical Genetics has a broad range of scientific interests. The Department conducts studies on the genetics of cystic fibrosis, primary ciliary dyskinesia and diseases related to genetically determined defects of motile cilia. Department also investigates the molecular and genetic aspects of hematologic diseases (especially acute T-cell lymphoblastic leukemia), as well as monitoring of the treatment response (so called residual disease). Last, but not least, we conduct research on issues related to the genetic diversity of human populations.  In all cases, we are interested not only in broadening of the basic knowledge, but also its practical application.

Keywords:

Featured publications

Czy jesteśmy w Polsce przygotowani na upowszechnienie nowoczesnych testów genetycznych?

Witt M

Nauka, 2/2020, str.: 39–50, doi:10.24425/nauka.2020.132631

MNiSW-20

Featured research projects

1. STRATEGMED research project

STRATEGMED

Personalization of childhood acute lymphoblastic leukemia treatment in Poland
(PersonALL)

realized within the STRATEGMED-III program „Prevention and treatment of civilization diseases”
Project consortium members:

Silesian Medical University, Katowice
Institute of Innovative Techniques EMAG in Katowice
Medical University of Lodz
Institute of Human Genetics PAS in Poznan
Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun
Medical University of Lublin
Medical University of Wroclaw
Medical University of Poznan
Warsaw Medical University
Medical University of Bialystok
Gdansk Medical University
Pomeranian Medical University in Szczecin
NET-O-LOGY company

2. NCN research project 2016/20/T/NZ4/00525

NCN-en

Drug-stimulated premature termination codon readthrough in selected genes involved in primary ciliary dyskinesia (PCD)
(2016-2018)

3. NCN research project 2014/13/B/NZ2/03858

NCN-en

Whole exome sequencing in Polish population of patients – search for the genetic basis of primary ciliary dyskinesia, PCD
(2015-2018)

4. NCN research project 2014/15/B/NZ2/03394

NCN-en

Next-generation sequencing of miRNA transcriptome and functional in vitro study: towards unravelling pathomechanisms and heterogeneity of pediatric T-cell acute lymphoblastic leukemia (T-ALL)
(2015-2018)

5. NCN research project 2013/11/N/NZ5/03730

NCN-en

Genetics of pediatric T-cell acute lymphoblastic leukemia
(2014-2017)

 

6. NCN research project 2013/09/D/NZ4/01692

NCN-en

The influence of external factors on the dynamics of the respiratory epithelium differentiation in the context of the use of the different in vitro ciliogenesis regimens in studies on primary ciliary dyskinesia
(2014-2017)

7. The research project of the European Union COST BM1407

beat-pcd logo

International project financed from EU funds: “Translational research in primary ciliary dyskinesia – bench, bedside, and population perspectives (BEAT-PCD)”
http://www.cost.eu/COST_Actions/bmbs/BM1407
(2015-2019)

8. The research project of the European Union COST IS1303

CHipMe_logo
International project financed from EU funds: “Citizen’s Health through public- private Initiatives: Public health, Market and Ethical perspectives’ CHIP-ME
http://www.cost.eu/COST_Actions/isch/IS1303
(2013-2017)

9. The research project of the European Union FP7 305404

BESTCILIA   SFP

International project financed from EU funds (FP7): „Better Experimental Screening and Treatment for Primary Ciliary Dyskinesia” BESTCILIA

www.bestcilia.eu

(2013-2016)

 

10. Projekt badawczy Ministerstwa Nauki nr OR00 0027 12

MNiSW-EN

Multi-center R & D project “Identification of genetic markers useful for identifying human populations (AriaDNA)”

(2011-2014)

Collaborations

Awards

Awarded: mgr Alicja Rabiasz
Nomination for the Polish Intelligent Development Award 2020
Given by: Polish Intelligent Development

Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: : “In search for new genes involved in primary ciliary dyskinesia pathogenesis: functional screening of candidate genes using RNA interference"

Awarded: mgr inż. Monika Drobna
Scholarship from the City of Poznań for young researchers
Given by: Scholarship of City of Poznań

Monika Drobna, MSc. – PhD student from the Department of Molecular and Clinical Genetics has received a scholarship from the City of Poznań for young researchers for outstanding scientific activity and scientific achievements in the field of molecular research including microRNA, which are the basis of childhood T-cell acute lymphoblastic leukemia.

Awarded: mgr inż. Monika Drobna
Honorable mention
Given by: Poznań branch of the Polish Academy of Sciences

Monika Drobna, MSc, was granted a honorable mention in the contest for the best original paper published in 2018, with a PhD student as the leading author, organized by the Poznań branch of the Polish Academy of Sciences. The work entitled „Identification of endogenous control miRNAs for RT-qPCR in T-cell acute lymphoblastic leukemia” [Drobna M, Szarzyńska-Zawadzka B, Daca-Roszak P, Kosmalska M, Jaksis R, Witt M, Dawidowska M; Int J Mol Sci, 2018, 19 (10): e2858].

Awarded: dr n. med. Bronisława Szarzyńska-Zawadzka
The Kosciuszko Foundation Grant
Given by: Kosciuszko Foundation

Bronisława Szarzyńska-Zawadzka has been awarded a Kosciuszko Foundation Grant for the academic year 2019/2020, to visit University of New Mexico, NM, US. During the 3-month visit at University of New Mexico in Albuquerque Bronisława Szarzyńska-Zawadzka will study tumor suppressor function of RNA-binding protein QKI-5 in T-cell lineage acute lymphoblastic leukemia.
The Kosciuszko Foundation promotes closer ties between Poland and the United States through educational, scientific and cultural exchanges. The Kosciuszko Foundation annually awards a number of Fellowships/Grants to Poles for advanced study, research, and/or teaching at universities and other institutions of higher learning in the United States.

Awarded: dr n. med. Bronisława Szarzyńska-Zawadzka
Award for the best review publication in 2018
Given by: Director of the Institute of Human Genetics PAS

the best review publication in 2018 entitled: "T-cell acute lymphoblastic leukemia from miRNA perspective” published in the prestigious journal Blood Reviews

Awarded: mgr inż. Monika Drobna
Award for the best review publication in 2018
Given by: Director of the Institute of Human Genetics PAS

the best review publication in 2018 entitled: "T-cell acute lymphoblastic leukemia from miRNA perspective" published in the prestigious journal Blood Reviews

Awarded: dr hab. n. med. Małgorzata Dawidowska
Award for the best review publication in 2018
Given by: Director of the Institute of Human Genetics PAS

the best review publication in 2018 entitled: "T-cell acute lymphoblastic leukemia from miRNA perspective" published in the prestigious journal Blood Reviews

Awarded: prof. dr hab. n. med. Michał Witt
Medal im. Jędrzeja Śniadeckiego.
Given by: Wydział V Nauk Medycznych PAN, Uchwała Wydziału Nauk Medycznych PAN z dnia 22.11.2018 r. Wręczenie Medalu – Warszawa, 13 grudnia 2018 r.

Za wybitne wyniki badań naukowych z zakresu genetyki klinicznej człowieka, ze szczególnym uwzględnieniem diagnostyki mukowiscydozy i zespołu nieruchomych rzęsek oraz rozwijanie poradnictwa genetycznego.

Awarded: mgr inż. Monika Drobna
Stypendia dla Najlepszych Doktorantów na rok akademicki 2018/2019,
Given by: Środowiskowe Studium Doktoranckie Instytutu Chemii Bioorganicznej PAN

Awarded:
mgr Alicja Rabiasz
prof. dr hab. n. med. Michał Witt
prof. dr hab. n. med. Ewa Ziętkiewicz
Gold Helix
Given by: Polish Human Genetics Association

Poster titled "Schmidtea mediterranea as a model organism to study novel genes potentially involved in primary ciliary dyskinesia pathogenesis" presented by Alicja Rabiasz, Michał Witt, Ewa Ziętkiewicz, was awarded a "Gold Helix" by the Polish Human Genetics Association during IXth Convention of Polish Human Genetics Association in Bydgoszcz