My main topic of interest includes T cell receptor gene rearrangements, genome lesions and their consequences at the transcriptome level in T cell acute lymphoblastic leukemia and lymphoma.
prof. dr hab. n. med. Grzegorz Przybylski
Publications
Dual role of BCL11B in T-cell malignancies.
Przybylski GK, Przybylska J, Yangqiu L
Blood Science, 2024, 6 (4):p e00204, October 2024. | DOI: 10.1097/BS9.0000000000000204IF-1.5 MNiSW-20
T-cell lymphoma patient harboring BCL11B mutations had favorable overall survival.
Chen C, Huang L, Liu S, Jiang X, Chen F, Wei X, Guo H, Zeng X, Zeng C, Przybylski GK, Li W, Li Y
Asia Pac J Clin Oncol, 2024 Feb; 20 (1): 81-86. doi: 10.1111/ajco.14000. Epub 2023 Aug 27.IF-1.4 MNiSW-40
BCL11B promotes T-cell acute lymphoblastic leukaemia cell survival via the XRCC5/C11ORF21 axis.
Yu X, Li Y, Yang P, Wang Y, Liu X, Cai L, Lai J, Zhang Y, Zha X, Przybylski GK, Xu L, Li Y
Clin Transl Med. 2024 Feb;14(2):e1580. doi: 10.1002/ctm2.1580IF-7.9 MNiSW-20
BCL11B Mutations Are Associated with Higher CD8+ T-Cell Percentage and Favorable Clinical Outcomes in Patients with T-Cell Acute Lymphoblastic Leukemia.
Chen C, Zhang Y, Zeng X, Zeng Ch, Przybylski GK, Li Y
Clinical Medicine Insights-Oncology, 2023, 17: 1-3; 10.1177/11795549231216427.IF-2.2 MNiSW-100
TMEM244 Is a Long Non-Coding RNA Necessary for CTCL Cell Growth.
Rassek K, Iżykowska K, Żurawek M, Pieniawska M, Nowicka K, Zhao X, Przybylski G
Int J Mol Sci (MDPI), 2023, 24, 3531; doi: 10.3390/ijms24043531IF-5.6 MNiSW-140
TMEM244 gene expression as a potential blood diagnostic marker distinguishing Sezary syndrome from mycosis fungoides and benign erythroderma.
Rassek K, Iżykowska K, Żurawek M, Nowicka K, Joks M, Olek-Hrab K, Olszewska B, Sokołowska-Wojdyło M, Biernat W, Nowicki RJ, Przybylski GP
J Invest Dermatol, 2023 Feb; 143 (2): 344-347.e3, epub 2022 Sept 7, doi: 10.1016/j.jid.2022.08.046IF-6.5 MNiSW-140
High expression of TMEM244 is associated with poor overall survival of patients with T-cell lymphoma.
Chen C, Chen S, Luo G, Wang L, Zeng C, Przybylski GK, Li Y
Biomarker Res, 2022 Jul 12;10 (1):46, 4 strony, doi: 10.1186/s40364-022-00395-zIF-8,633 MNiSW-100
Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model.
Przybylski GK, Korsak D, Iżykowska K, Nowicka K, Zalewski T, Tubacka M, Mosor M, Januszkiewicz-Lewandowska D, Frydrychowicz M, Boruczkowski M, Dworacki G, van den Brandt J, Grabarczyk P, Schmidt CA, Zeng C, Li Y
Int J Mol Sci (MDPI) 2022 Apr 29; 2022, 23 (9):4932, 10 stron, doi: 10.3390/ijms23094932IF-5,924 MNiSW-140
The Usefulness of Cell-Based and Liquid-Based Urine Tests in Clarifying the Diagnosis and Monitoring the Course of Urothelial Carcinoma. Identification of Novel, Potentially Actionable, RB1 and ERBB2 Somatic Mutations.
Kałużewski T, Przybylski GK, Bednarek M, Glazar S, Grabiec M, Jędrzejczyk A, Kępczyński Ł, Kubiak I, Kucharska D, Morel A, Owczarek M, Rożniecki M, Sałamunia J, Szewczyk D, Szwalski J, Kałużewski B
J Personal Med, 2021 Apr 30;11 (5):e362, 18 str., doi: 10.3390/jpm11050362.IF-4,433 MNiSW-70
Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemia.
Li K, Chen C, Gao R, Yu X, Huang Y, Chen Z, Liu Z, Chen S, Luo G, Huang X, Przybylski GK, Li Y, Zeng C
Biomarker Res, 2021 Mar 4;9(1):17, 4 str, doi: 10.1186/s40364-021-00270-3.IF-4,866 MNiSW-100
All publications
Events
18.06.2015 Where:
Szczecin, Poland
Advances in cell therapy, transplantology i hematology. Przybylski G.K Current strategies for identification of genes involved in leukemogenesis.
7.05.2014 Where:
Greifswald, Niemcy
“New aspects of molecular pathogenesis in lymphocytic malignancies”. Przybylski G.K. Mouse model to study BCL11B function in T cell malignancies.
12.09.2013 Where:
Poznań
Identification of multiple complex rearrangements associated with deletions in the 6q23-27 region in Sézary syndrome.
07.02.2013 Where:
Berlin, Niemcy
Identification of multiple complex rearrangements associated with deletions in the 6q23-27 region in Sézary syndrome.
Awards
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Polish Intelligent Development Award 2020 in the category: Scientist of the future
Given by: Intelligent Development Center
Prof. Grzegorz Przybylski M.D., Ph.D. became a laureate of the Polish Intelligent Development Award 2020 in the category: Scientist of the future for the realization of projects: “Double impact of BCL11B gene suppression for the targeted therapy of T-cell neoplasms”, “Elucidating the function of the transmembrane protein TMEM244 and its role in the development of lymphoid malignancies” and “BCL11B - Potential Therapeutic Target in T cell Neoplasms”.
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Nomination for the Polish Intelligent Development Award 2020
Given by: The Center of Intelligent Development
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: “Double impact of BCL11B gene suppression for the targeted therapy of T-cell neoplasms”, funded by the NCBiR.
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Silver Cross of Merit
Given by: President of the Republic of Poland
For the merit for science development .
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
„Golden helix”
Given by: Polish Society of Genetics in Classical and Molecular Cytogenetics Section
For a poster: K. Iżykowska, M. Zawada, K. Nowicka, P. Grabarczyk, W.D. Ludwig, C.A. Schmidt, G.K. Przybylski: Cytogenetic and molecular characterization of chromosomal aberrations in T-cell large granular lymphocyte leukemia. IV Polish Congress of Genetics, Poznań, 10-13.09.2013.
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Cytogenetic award ,,Stork''
Given by: IV Polish Congress of Genetics
For a team work: K. Iżykowska, M. Zawada, K. Nowicka, P. Grabarczyk, W.D. Ludwig, C.A. Schmidt, G.K. Przybylski: Cytogenetic and molecular characterization of chromosomal aberrations in T-cell large granular lymphocyte leukemia. Poznań, 10-13.09.2013.
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Award for outstanding presentation
Given by:
For outstanding presentation Grzegorz K. Przybylski, Piotr Grabarczyk, Christian A. Schmidt BCL11B Gene - Potential Therapeutic Target in T Cell Neoplasms at the Bioconnect 2013 Conference 15-16.05.2013. Poznań.
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Title of honor professor
Given by: Jinan University
Title of honor professor at the Jinan University, Guangzhou, China
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
Award for outstanding oral presentation
Given by: Polish Society of Experimental and Clinical Immunology
For outstanding oral presentation „Two Subpopulations of Naive Helper T cells with different T Cell Receptor Excision Circle (TREC) content in the peripheral blood of adult individuals” XI Meeting of the Polish Society of Experimental and Clinical Immunology.
Awarded:
prof. dr hab. n. med. Grzegorz Przybylski
UNESCO young scientist fellowship
Given by: Free University of Berlin
For a stay in the Department of Hematology/Oncology, Free University of Berlin, Germany
