The department carries out studies into the molecular background of male infertility and the biological properties of stem cells (of myogenic origin) from the perspective of their application in organ regeneration. We apply the tools of systemic biology to the transcriptomic identification of gene expression in dysfunctional male gonads and DNA arrays of infertile individuals to identify novel genes. In the second module, studies of pro-generative properties of stem cells are investigated in clinical trials for regeneration of a) post-infarction heart, b) anal sphincters and c) muscular dystrophies.

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Featured publications

Featured research projects

1. National Science Centre research project 2017/26/D/NZ5/00789

“Novel causative genetic variants in azoospermia: whole genome analysis and functional in vitro studies”

Duration: 2018-2021

2. National Science Centre research project 2017/25/B/NZ5/01131

“Genetically corrected autologous myogented with nanocapsules as the next generation formula for treatment of Duchenne disease.”

Duration: 2018-2021

3. National Science Centre research project 2015/17/B/NZ2/01157

“Schearching for novel genes essential for human oligo- i azoospermia – mouse „knockout” model”

Duration: 2016-2020

4. National Science Centre research project 2015/17/D/NZ5/03442

“Analysis of DNA methylation pattern in spermatozoa of infertile men with oligozoospermia”

Duration: 2016-2020

5. National Centre for Research and Development (Applied Research Programme) research project PBS3/A7/27/2015

administracja

“Molecular imaging (including nanotechnology) for monitoring of implanted stem cells and their pro-regenerative functions – STEMNanoT”

Duration:  2015 – 2020

 

6. National Centre for Research and Development (STRATEGMED Programme)research project STRATEGMED1/233209/12/NCBR/2015

strategmed

“Application of glial progenitors for treatment of ALS – GRP&ALS”

Duratiob: 2015 – 2019

 

7. National Centre for Research and Development (STRATEGMED Programme) research project STRATEGMED1/233624/5/NCBR/2014

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“Low molecular weight epigenetic modulators for activation of pluripotency of cells for regenerative medicine purposes – EPI CELL”

Duration: 2015 – 2019

 

8. National Science Centre research project 2015/19/B/NZ5/02241

“Verification of the hypothesis of oxidative stress, apoptosis and immune factor as the mechanisms responsible for the poor semen quality in men exposed to genital heat stress”

 Duration: 2016-2019

9. National Science Centre research project 2014/15/B/ST4/04946

“Quantification of cancer tissue oxygenation measured with BOLD-MRI – calibration with oximetry EPRI”

Duration: 2015 – 2019

10. National Science Centre research project 2014/13/B/NZ3/04646

“Cytoprotective role of antioxidants towards cells of myogenic origin in in vitro and in situ conditions.”

Duration:  2015 – 2018

Collaborations

Poznan University of Medical Sciences

Nanobiomedical Centre Adam Mickiewicz University In Poznań

University of Warmia and Mazury in Olsztyn

University of Warsaw Biological and Chemical Research Centre

Centre for Postgraduate Medical Education, Warsaw

Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań

Institute of Gynaecology and Obstetrics in Poznań

MedPolonia Private Specialist Hospitals, Poznań

Institute of Immunology and Experimental Therapy, Polish Academy of Sciences in Wroclaw

Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw

Jagiellonian Centre for Experimental Therapeutics, Kraków

Pomeranian Medical University in Szczecin, Department of Histology and Developmental Biology, Szczecin

University Hospital of Lord’s Transfiguration, Partner of Poznań University of Medical Sciences, Poznań

Second Clinic of General Surgery, Jagiellonian University in Kraków

Johns Hopkins University School of Medicine, Institute of Cell Engineering, Baltimore, MD, USA.

University of Vienna, Vienna, Austria, Cardiac Department, Austria

Freie University, Department of Physics ,Germany

Yuriy Fedkovych Chernivtsi National University, Ukraine

Danylo Halytsky Lviv National Medical University, Department of Paediatric Surgery, Ukraine.

Institute of Hereditary Pathology of National Academy of Medical Sciences of Ukraine, Ukraine

University of Pittsburgh, School of Medicine, Department of OBGYN and Reproductive Science,  Pittsburgh, Pennsylvania, USA

Awards

Awarded:
dr n. med. Marta Olszewska
dr hab. n. med. Monika Frączek
prof. dr hab. n. med. Maciej Kurpisz
Oustanding Paper Award for the best paper published in 2019 in Asian Journal of Andrology
Given by: Editorial Office of Asian Journal of Andrology (Wolters Kluwer)

Oustanding Paper Award for the best paper published in 2019 in Asian Journal of Andrology Olszewska M, Barciszewska MZ, Fraczek M, Huleyuk N, Chernykh VB, Zastavna D, Barciszewski J, Kurpisz M:
Global methylation status of sperm DNA in carriers of chromosome structural aberrations.
Asian J Androl, 2017, 19: 117-124. https://dx.doi.org/10.4103/1008-682X.168684

Awarded: dr n. med. Marta Olszewska
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future.
Given by: Polish Intelligent Development

Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: : “Analysis of DNA methylation pattern in spermatozoa of infertile men with oligozoospermia”. The material regarding the nominee is available on website: https://rzeczo.pl/blog/2020/07/08/nieplodnosc-to-tez-epigenetyka/.

Awarded: dr hab. n. med. Monika Frączek
Nomination for the Polish Inteligent Develpoment Award 2020
Given by: The center of intelligent development

Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: ‘Verification of the hypothesis of oxidative stress, apoptosis and immune factor as the mechanisms responsible for the poor semen quality in men exposed to genital heat stress’. The winners of this prestigious award have been for five years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.

Awarded: dr n. med. Agnieszka Malcher (Wacławska)
Nomination for the Polish Inteligent Development Award 2019
Given by: Centrum for Intelligent Development

Dr n. med. Agnieszka Malcher has been nominated for the Polish Intelligent Development Award 2019 in the category: Scientist of the future for the project: "Novel causative genetic variants in azoospermia: whole genome analysis and functional in vitro studies." The winners of this prestigious award have been for four years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.

Awarded: dr n. med. Agnieszka Malcher (Wacławska)
Short-Term Fellowships
Given by: European Molecular Biology Organization (EMBO).

Short-Term Fellowships of European Molecular Biology Organization (EMBO) to implement the project CRISPR/Cas9 system based spermatogenesis impairment in vitro modeling of human male gonad. The research will be conducted in Max Planck Institute for Molecular Genetics in Germany.

Awarded: dr n. med. Agnieszka Zimna
Scholarship
Given by: the Foundation for Polish Science

For the 27th time, the Foundation for Polish Science awarded START scholarships to the most talented young scientists from all over Poland. Among 100 young researchers was Dr. Agnieszka Zimna from the Department of Reproductive Biology and Stem Cells.

Awarded: prof. dr hab. n. med. Maciej Kurpisz
The Ludwik Hirszfeld prize
Given by: Chairman and the Board of Polish Society for Experimental and Clinical Immunology

For his outstanding contribution to development of Immunology in Poland (Warsaw, 8th June, 2017)

Awarded: prof. dr hab. n. med. Maciej Kurpisz
The award of the Editor-in-Chief of the Asian Journal of Andrology.
Given by: The Editor-in-Chief of the Asian Journal of Andrology.

The award for the oustanding reviewer for professor Maciej Kurpisz

The award of the Editor-in-Chief of the Asian Journal of Andrology for professor Maciej Kurpisz for the best evaluations of scientific reports in AJA in 2016.

Awarded:
mgr Kamil Wierzbiński
Tomasz Szymański
dr hab. n. med. Natalia Rozwadowska
dr n. med. Agnieszka Zimna
dr n. med. Karolina Nowicka-Bauer
dr n. med. Agnieszka Malcher (Wacławska)
mgr inż. Magdalena Nowaczyk
prof. dr hab. n. med. Maciej Kurpisz
Nagroda za najlepszą prezentację konferencyjną.
Given by: Polish Cardiac Society.

Oral Presentation: “Potential use of superparamagnetic iron oxide nanoparticles for bioimaging of myoblasts in post-infarction heart stem cells therapy” during the XXI Symposium of the Section of Experimental Cardiology of Polish Cardiac Society and the Committee of Physiological Sciences and Pharmacology; Polish Academy of Sciences; Rynia, 13-15.10.2016.

Awarded: dr n. med. Marta Olszewska
The Young Prize named after Prof. Michał Bokiniec
Given by: PTA

Genetic dosage and position effect of small supernumerary marker chromosome (sSMC) in human sperm nuclei in infertile male patient, Scientific Reports, 2015, 5: 17408; 18th Andrology Day, Gdańsk, 30.09.-01.10.2016.