The department carries out studies into the molecular background of male infertility and the biological properties of stem cells (of myogenic origin) from the perspective of their application in organ regeneration. We apply the tools of systemic biology to the transcriptomic identification of gene expression in dysfunctional male gonads and DNA arrays of infertile individuals to identify novel genes. In the second module, studies of pro-generative properties of stem cells are investigated in clinical trials for regeneration of a) post-infarction heart, b) anal sphincters and c) muscular dystrophies.
The effect of Robertsonian translocations on the intranuclear positioning of NORs (nucleolar organizing regions) in human sperm cells.
Wiland E, Olszewska M, Huleyuk N, Chernykh VB, Kurpisz M;Scientific Rep, 2019, 9:e2213 (12 str)., doi.org/10.1038/s41598-019-38478-x.
Wiland E, Frączek M, Olszewska M, Kurpisz M;Sci Rep, 2016, 6: 31614.
The effect of bacteriospermia and leukocytospermia on conventional and nonconventional semen parameters in healthy young normozoospermic males.
Frączek M, Hryhorowicz M, Gill K, Zarzycka M, Gaczarzewicz D, Jedrzejczak P, Bilinska B, Piasecka M, Kurpisz M;J Reprod Immunol, 2016, (17) 118: 18-27.
Human myoblast transplantation in mice infarcted heart alters the expression profile of cardiac genes associated with left ventricle remodeling.
Wiernicki B, Rozwadowska N, Malcher A, Kolanowski T, Zimna A, Rugowska A, Kurpisz M;International Journal of Cardiology, 2016, 202: 710-721.
FISH and array CGH characterization of de novo derivative Y chromosome (Yq duplication and partial Yp deletion) in an azoospermic male.
Wiland E, Yatsenko AN, Kishore A, Stanczak H, Zdarta A, Ligaj M, Olszewska M, Wolski JK, Kurpisz M;Reprod Biomed Online, 2015,31 (2): 217-224.
Yatsenko AN, Georgiadis AP, Röpke A, Berman AJ, Jaffe T, Olszewska M, Westernströer B, Sanfilippo J, Kurpisz M, Rajkovic A, Yatsenko SA, Kliesch S, Schlatt S, Tüttelmann F;N Engl J Med, 2015, 372 (22): 2097-2107.
Fraczek M, Wiland E, Piasecka M, Boksa M, Gaczarzewicz D, Szumala-Kakol A, Kolanowski T, Beutin L, Kurpisz M;Fertil Steril, 2014, 102 (3): 711-719.
In vitro and in vivo characteristics of connexin 43-modified human skeletal myoblasts as candidates for prospective stem cell therapy for the failing heart.
Kolanowski TJ, Rozwadowska N, Malcher A, Szymczyk E, Kasprzak JD, Mietkiewski T, Kurpisz M;Int J Cardiol, 2014, 173 (1): 55-64.
Olszewska M, Huleyuk N, Fraczek M, Zastavna D, Wiland E, Kurpisz M;Reproduction, 2014, 147 (5): 659-670.
Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.
Malcher A, Rozwadowska N, Stokowy T, Kolanowski T, Jedrzejczak P, Zietkowiak W, Kurpisz M;Fertil Steril, 2013, 100 (6): 1686-1894.
Nowicka-Bauer K, Kurpisz M;Expert Rev Proteomics, 2013, 10 (6): 591-605.
The gene expression analysis of paracrine/autocrine factors in patients with spermatogenetic failure compared with normal spermatogenesis.
Malcher A, Rozwadowska N, Stokowy T, Jedrzejczak P, Zietkowiak W, Kurpisz M;Am J Reprod Immunol, 2013, 70 (6): 522-528.
Characterisation of nuclear architectural alterations during in vitro differentiation of human stem cells of myogenic origin.
Rozwadowska N, Kolanowski T, Wiland E, Siatkowski M, Pawlak P, Malcher A, Mietkiewski T, Olszewska M, Kurpisz M;PLoS One, 2013, 8 (9): e73231.
Featured research projects
1. National Science Centre research project 2017/26/D/NZ5/00789
2. National Science Centre research project 2017/25/B/NZ5/01131
3. National Science Centre research project 2015/17/B/NZ2/01157
4. National Science Centre research project 2015/17/D/NZ5/03442
5. National Centre for Research and Development (Applied Research Programme) research project PBS3/A7/27/2015
6. National Centre for Research and Development (STRATEGMED Programme)research project STRATEGMED1/233209/12/NCBR/2015
7. National Centre for Research and Development (STRATEGMED Programme) research project STRATEGMED1/233624/5/NCBR/2014
8. National Science Centre research project 2015/19/B/NZ5/02241
9. National Science Centre research project 2014/15/B/ST4/04946
10. National Science Centre research project 2014/13/B/NZ3/04646
University of Vienna, Vienna, Austria, Cardiac Department, Austria
Freie University, Department of Physics ,Germany
dr n. med. Marta Olszewska
dr hab. n. med. Monika Frączek
prof. dr hab. n. med. Maciej Kurpisz
Oustanding Paper Award for the best paper published in 2019 in Asian Journal of Andrology
Oustanding Paper Award for the best paper published in 2019 in Asian Journal of Andrology Olszewska M, Barciszewska MZ, Fraczek M, Huleyuk N, Chernykh VB, Zastavna D, Barciszewski J, Kurpisz M:
Global methylation status of sperm DNA in carriers of chromosome structural aberrations.
Asian J Androl, 2017, 19: 117-124. https://dx.doi.org/10.4103/1008-682X.168684
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future.
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: : “Analysis of DNA methylation pattern in spermatozoa of infertile men with oligozoospermia”. The material regarding the nominee is available on website: https://rzeczo.pl/blog/2020/07/08/nieplodnosc-to-tez-epigenetyka/.
Nomination for the Polish Inteligent Develpoment Award 2020
Nomination for the Polish Intelligent Development Award 2020 in the category: Sciencist of the future for the project: ‘Verification of the hypothesis of oxidative stress, apoptosis and immune factor as the mechanisms responsible for the poor semen quality in men exposed to genital heat stress’. The winners of this prestigious award have been for five years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.
Nomination for the Polish Inteligent Development Award 2019
Dr n. med. Agnieszka Malcher has been nominated for the Polish Intelligent Development Award 2019 in the category: Scientist of the future for the project: "Novel causative genetic variants in azoospermia: whole genome analysis and functional in vitro studies." The winners of this prestigious award have been for four years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.
Short-Term Fellowships of European Molecular Biology Organization (EMBO) to implement the project CRISPR/Cas9 system based spermatogenesis impairment in vitro modeling of human male gonad. The research will be conducted in Max Planck Institute for Molecular Genetics in Germany.
For the 27th time, the Foundation for Polish Science awarded START scholarships to the most talented young scientists from all over Poland. Among 100 young researchers was Dr. Agnieszka Zimna from the Department of Reproductive Biology and Stem Cells.
The Ludwik Hirszfeld prize
For his outstanding contribution to development of Immunology in Poland (Warsaw, 8th June, 2017)
The award of the Editor-in-Chief of the Asian Journal of Andrology.
The award for the oustanding reviewer for professor Maciej Kurpisz
The award of the Editor-in-Chief of the Asian Journal of Andrology for professor Maciej Kurpisz for the best evaluations of scientific reports in AJA in 2016.
mgr Kamil Wierzbiński
dr hab. n. med. Natalia Rozwadowska
dr n. med. Agnieszka Zimna
dr n. med. Karolina Nowicka-Bauer
dr n. med. Agnieszka Malcher (Wacławska)
mgr inż. Magdalena Nowaczyk
prof. dr hab. n. med. Maciej Kurpisz
Nagroda za najlepszą prezentację konferencyjną.
Oral Presentation: “Potential use of superparamagnetic iron oxide nanoparticles for bioimaging of myoblasts in post-infarction heart stem cells therapy” during the XXI Symposium of the Section of Experimental Cardiology of Polish Cardiac Society and the Committee of Physiological Sciences and Pharmacology; Polish Academy of Sciences; Rynia, 13-15.10.2016.
The Young Prize named after Prof. Michał Bokiniec
Genetic dosage and position effect of small supernumerary marker chromosome (sSMC) in human sperm nuclei in infertile male patient, Scientific Reports, 2015, 5: 17408; 18th Andrology Day, Gdańsk, 30.09.-01.10.2016.