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dr n. med. Agnieszka Malcher

I am a graduate of Master Degree in Biotechnology at Adam Mickiewicz University in Poznan. I started cooperation with the Institute of Human Genetics PAS in the Department of Reproductive Biology and Stem Cells in 2009. From the beginning, my interest focused on the process of spermatogenesis and cell differentiation, including stem cells. I had the opportunity to participate in several projects related to microarrays to identify genes specifically dedicate for the molecular diagnosis of male infertility; as well as stem cell research in the context of myocardial regenerative therapy.

Links:

https://www.linkedin.com/in/agnieszka-malcher/

https://orcid.org/0000-0002-3433-6990

Scientific functions:

– Inspector for the Safety of Confined Use of GMMs and GMOs (since 2024)

https://igcz.poznan.pl/en/institute/young-scientist-council/

– Head of the Council of Young Scientists of IHG PAS (since 2022)
– Deputy head of the Council of Young Scientists of IHG PAS (2019-2022)
– Member of the FNP expert team (2018)

Grants:

MNiSW, NdS-II/SP/0288/2024/01: Searching for the causes of male infertility – high-throughput genomic study of the Polish population: co-author and main investigator (2024-2029)

2020/37/B/NZ5/00549: Systematic genomic search for novel genes/variants in consanguineous families including males with reproductive failure: co-author and main investigator (2021-2025)

2017/26/D/NZ5/00789: Novel causative genetic variants in azoospermia: whole genome analysis and functional in vitro studies: leader of the project (2018-2023)

2012/05/N/NZ5/00893: Identification of novel genes involved in spermatogenesis and male infertility: leader of the project (2013-2016)

Publications

Variants in GCNA, X-linked germ-cell genome integrity gene, identified in men with primary spermatogenic failure.

Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieño-Enríquez MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O’Bryan MK, Conrad DF, Kurpisz M, Tüttelmann F, Yatsenko AN; GEMINI Consortium

Hum Genet, 2021 Aug;140 (8):1169-1182. doi: 10.1007/s00439-021-02287-y. Epub 2021 May 7.

IF-4,132 MNiSW-100

Events

Date:
26-28.06.2014 Where:
Wrocław

15th Congress of the Polish Society of Experimental and Clinical Immunology

Date:
1-13.IX.2013 Where:
Poznań

IV Polish Congress of Genetics

Date:
XI.2012 Where:
Berlin

7th European Congress of Andrology (ECA)

Date:
16-23.10.2014 Where:
Honolulu, USA

ASRM-American Society for Reproductive Medicine 2014 Annual Meeting

Date:
1-13.IX.2013 Where:
Poznan

IV Polski Kongres Genetyki

Date:
13-15.05.2013 Where:
Barcelona, Hiszpania

6th Congress of the International Network for Young Researchers in Male Fertility

Date:
23-26.02. 2013 Where:
Melbourne, Australia

The 10th International Congress of Andrology

Date:
29.09 - 1.10.2011 Where:
Edynburg, UK

4th Congress of the International Network for Young Researchers in Male Fertility

Date:
8-10.09.2011 Where:
Polańczyk, Polska

VI Meeting of the Society for Reproductive Biology

Awards

Awarded: dr n. med. Agnieszka Malcher
Nomination for the Polish Inteligent Development Award 2019
Given by: Centrum for Intelligent Development

Dr n. med. Agnieszka Malcher has been nominated for the Polish Intelligent Development Award 2019 in the category: Scientist of the future for the project: "Novel causative genetic variants in azoospermia: whole genome analysis and functional in vitro studies." The winners of this prestigious award have been for four years organizations and people who in their work show a constant focus on the future, constituting the basis of sustainable economic development of the country.

Awarded: dr n. med. Agnieszka Malcher
Short-Term Fellowships
Given by: European Molecular Biology Organization (EMBO).

Short-Term Fellowships of European Molecular Biology Organization (EMBO) to implement the project CRISPR/Cas9 system based spermatogenesis impairment in vitro modeling of human male gonad. The research will be conducted in Max Planck Institute for Molecular Genetics in Germany.

Awarded:
mgr Kamil Wierzbiński
Tomasz Szymański
dr hab. n. med. Natalia Rozwadowska
dr n. med. Agnieszka Zimna
dr n. med. Karolina Nowicka-Bauer
dr n. med. Agnieszka Malcher
dr n. med. i n. o zdr. Magdalena Nowaczyk
prof. dr hab. n. med. Maciej Kurpisz
Nagroda za najlepszą prezentację konferencyjną.
Given by: Polish Cardiac Society.

Oral Presentation: “Potential use of superparamagnetic iron oxide nanoparticles for bioimaging of myoblasts in post-infarction heart stem cells therapy” during the XXI Symposium of the Section of Experimental Cardiology of Polish Cardiac Society and the Committee of Physiological Sciences and Pharmacology; Polish Academy of Sciences; Rynia, 13-15.10.2016.

Awarded: dr n. med. Agnieszka Malcher
Award of the Polish Academy of Sciences
Given by: The Polish Academy of Sciences

For the best publication published in 2013: “Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.” Fertil Steril. 2013; 100(6): 1686–1694.e7, Poznan, 5 June 2014.

Awarded:
dr n. med. Agnieszka Malcher
dr hab. n. med. Natalia Rozwadowska
prof. dr hab. n. med. Maciej Kurpisz
"Golden Helix"
Given by: The Polish Genetics Society and the Polish Society of Human Genetics

For the poster: “Potential diagnostic and prognostic biomarkers in patients with nonobstructive azoospermia identified by gene expression profile analysis” by A. Malcher, N. Rozwadowska, T. Stokowy, P. Jędrzejczak, W. Zietkowiak, M. Kurpisz. IV Polish Congress of Genetics, 1–13 September 2013, Poznań, Poland.

Awarded: dr n. med. Agnieszka Malcher
Scholarship
Given by: Operational Programme Human Capital

Project “Scholarship support for Ph.D. students specializing in majors strategic for Wielkopolska’s development”, Sub-measure 8.2.2 Human Capital Operational Programme, co-financed by the European Union under the European Social Fund. 2012-2013